Endocrine Abstracts

Background: Glucose intolerance produces structural and functional changes in the arterial wall which contribute to the excess cardiovascular morbidity and mortality. The present study investigated association between glucose tolerance status and arterial stiffness in subjects with normal and impaired glucose regulation (IGR).Methods: The study group consisted of 283 Caucasian subjects, including 111 subjects with normal glucose tolerance (NGT), 61 subje...

Introduction: The Marine–Lenhart syndrome is a rare cause of hyperthyroidism that is associated with the simultaneous or sequential presence of characteristics related to Graves’ disease and toxic nodular or multinodular goiter. It’s validity as a disease is controversial and some authors believe that these are cases of hyperthyroidism where both etiologies coexist. The presence of hyperfunctioning nodules in Graves’ disease patients ranges between 0.8 and ...

Objective: Vascular atherosclerotic changes, mediated by environmental and genetic factors, develop years before an event. Detection of vascular damage, using ultrasonographic measurement of carotid IMT, is predictive of future cardiovascular events. The present study was designed to investigate the impact of gestational weight gain (GWG) on early atherosclerotic changes during late pregnancy, using intima media thickness (IMT), as well as placental vascular circulation and in...

Introduction: Metformin is effective in reducing cardiovascular mortality, however may decrease vitamin B12 and folate levels, and increase levels of homocysteine. Hyperhomocysteinemia is associated with adverse impact on lipid parameters and renal function. The present study was designed to determine the effect of homocysteine lowering therapy by using group B vitamins and folate supplementations on lipid metabolism especially HDL cholesterol as well as kidney function assess...

Internal jugular vein thrombosis (IJVT) is generally related to central venous access devices (CVADs) because of endothelial trauma or inflammation. Other reported causes include neck surgery complication, malignancies, deep neck infections, intravenous drug abuse, ovarian hyperstimulation syndrome and hypercoagulable states.We report the case of a 47-year-old woman presenting with acute neck pain, local swelling and fever. Neck ultrasound with Doppler s...

Introduction: Recently there has been a steady increase in direct costs for treatment of patients with diabetic foot. Therefore, cost-effectiveness analysis of different treatment strategies of patients is important for healthcare organizations and is an additional argument when deciding on the allocation of financial resources.Aim: A comparative analysis of cost-effectiveness of non-specialized and specialized medical care for patients with diabetic foo...

Background: Ukraine does not yet have a national program for control of iodine deficiency and there are no recent data on the severity of the iodine deficiency disorders (IDD) in the country.Objective: The aim of the present study was to assess current IDD status in eastern Ukraine.Design: We conducted school-based 30-cluster survey in children 6-11-year-old in urban and rural areas. We measured urinary iodine concentration (UI) an...

Objective: Levothyroxine (LT4) is the gold standard of care for primary hypothyroidism. For most patients, it fully resolves the symptoms of hypothyroidism. However, a small proportion of treated individuals continue to experience symptoms even when euthyroid. The management of such patients has generated significant controversy and public attention throughout the years. This systematic review aims to analyse and evaluate the existing evidence for the benefits...

A 71-year-old man presented to the emergency department with dyspnoea and general weakness. He had a history of stable COPD, coronary artery disease, abdominal aneurysm surgery, and prostate cancer. One month ago, he had survived a SARS-CoV-2 infection. His somatic status was normal, blood pressure was 115/65 mmHg, heart rate was 63/min, he was afebrile 36.6 °C with the exception of SpO2 which was 83%. His initial laboratory results showed severe hypercalcaemia (Ca 3.52 m...

Background: The combination of a toxic adenoma and Graves’ disease compose the Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2.7% of Graves’ disease patients and only few cases are reported in the literature.Patient findings: A 29-year-old female patient was referred to our outpatient clinic due to subclinical hyperthyroidism and a newly discovered thyroid nodule on the right thyroid lobe. She had no thyreotoxic symptoms ...