Endocrine Abstracts

Background and objective: Human recombinant growth hormone (hrGH/GH) is an injectable medication used commonly for growth hormone deficiency (GHD) and other health conditions that reduce growth and adult height. Daily GH injections can burden families and result in poor adherence. This study was conducted to investigate caregivers’ experiences, attitudes and preferences regarding pediatric GH treatment. At the time of data collection, the long-acting GH products were not ...

A 57-year-old woman presented with a 4-week history of lethargy, weight loss, polyuria, and polydipsia. Her only past medical history of note was hypertension for which she was taking lisinopril. On admission her initial investigations showed: glucose 22.6 mmol/l, capillary blood ketones Hi and a metabolic acidosis (H+57.5 nmol/l and HCO3− 13.7 mmol/l). She was commenced on the DKA protocol and her acidosis resolved without complication. She was maintained on ...

Introduction: Anaplastic thyroid carcinoma (ATC) is the most aggressive and invasive histological type of thyroid carcinomas. Frequently, upon diagnosis obstructive symptoms and loco-regional metastasis have already occurred. Presence of distant metastasis in the skeletal muscle in ATC is rare; and there are less than five documented cases reported worldwide.Case: A 68-year-old Filipino Male, presents with two-month history of pain on the right thigh. He...

Background: 3.8 per 1000 UK babies are stillborn, a large proportion of which are “unexplained”; aberrations in adrenal hormones and bile acids are possible contributors. In this study, we aimed to develop methodologies for simple laboratory measurement of adrenal hormone and bile acid concentrations that can be applied to postnatal samples from stillborn babies, using hair as a relatively stable medium, reflective of retrospective fetal hormone leve...

A 34-year-old African woman presented with a 4-month history of profound lethargy, weight loss and a 3-day history of vomiting, fever, confusion, and drowsiness. She had given birth to her third child 6 months previously. Her pregnancy and delivery were uncomplicated and she had breastfed for 5 months prior to discontinuing due to exhaustion.Investigations showed severe hypercalcaemia (4.94 mmol/l) and undetectable PTH. Hypercalcaemia was unresponsive to...

Adrenal crisis is a life-threatening complication in patients with adrenal insufficiency. In order to prevent critical situations, patients are supposed to increase their glucocorticoid dose in distressing situations. If dose adjustment is not sufficient, sooner or later patients will fall into a coma, followed by death. While health condition worsens patients usually call paramedics, followed by a decision for primary therapy and transportation to the nearest hospital. We ass...

Objective: To analyse the semen quality in patients with newly diagnosed non-Hodgkin lymphoma before starting the treatment.Materials and methods: We evaluated semen quality in 29 patients with non-Hodgkin lymphoma who underwent sperm banking in our clinic over a 9-year period. Semen samples were collected by masturbation after 2–7 days of sexual abstinence. Age at banking, semen volume, sperm concentration, and total and progressive sperm motility ...

Adrenal crisis is a life-threatening complication in patients with adrenal insufficiency. In order to prevent critical situations, patients have to increase their glucocorticoid dose in distressing situations. Continuous education of patients concerning dosage adaption in challenging situations seems to be important for long term management. As previously shown, both acute illness and emotional stress may lead to critical situations. In every outpatient visit patients should b...

Objective: To analyse the semen quality in patients with newly diagnosed lymphoma’s before starting the treatment.Materials and methods: We evaluated semen quality in 131 patient with lymphoma who underwent sperm banking in our clinic over a 14-year period. 102 patients had Hodgkin’s lymphoma, and 29 had non-Hodgkin’s lymphoma. Semen samples were collected by masturbation after 2–7 days of sexual abstinence. Age at banking, semen volu...

Background: Patients with complete androgen insensitivity syndrome (CAIS) who undergo gonadectomy have evidence of reduced bone mineral density (BMD) and perhaps, higher risk of fragility fractures. Because of this, hormonal replacement therapy (HRT), usually in the form of estrogen, is used as patients with CAIS have 46, XY genotypes having androgen receptor abnormalities making them resistant to the effects of androgen. Tibolone, a “selective tissue estrogenic activity...