Endocrine Abstracts

The aim of this study is to report a case of an unusual presentation of anaplastic thyroid carcinoma and describe its clinical, radiological and management particularities. Observation: We report the case of a 60 year-old female patient who presented with a two-week history of progressive aphagia, associated with hemoptysis. She also described recent shortness of breath, and a painless cervical mass evolving for 10 months, rapidly enlarging during the last four weeks. Her medi...

Objective: Identify the risk factors of hypoparathyroidism (hypoPT) after Total thyroidectomy (TT).Patients and Methods: Our study is a randomised clinical trial. It enrolled patients who underwent total thyroidectomy at the department of ENT surgery at Habib Bourguiba Hospital in Sfax between November 2020 and august 2021. We studied age, gender, type of surgery, duration of surgery, vitamin D level, magnesium level, histopathological exam, inadvertent ...

Aim: The purposes of our study are to study the effect of systematic calcium and vitamin D supplementation on parathyroid glands function after total thyroidectomy.Patients and Methods: We conducted a prospective cohort study, including patients undergoing total thyroidectomy. Patients were randomly divided into two groups: group 1: with prophylactic supplementation (24 patients) and group 2: without prophylactic supplementation (23 patients). For each p...

Introduction: Primary hyperparathyroidism is associated with lithiasis, but this has been universally considered to refer to kidney lithiasis. Sialolithiasis as a comorbidity or result of primary hyperparathyroidism is uncommon. We report a rare case of submandibular lithiasis in a child and discuss the etiological assessment of this condition.Materials and Methods: We report a rare case of submandibular lithiasis in a child revealing primary hyperparath...

Tribulus terrestris (TT) is used in the Arabic folk medicine to Q1 treat various diseases. The aim of this study was to investigate the protective effects of TT in diabetes mellitus (DM). Diabetes is known to increase reactive oxygen species (ROS) level that subsequently contributes to the pathogenesis of diabetes. Rats were divided into six groups and treated with either saline, glibenclamide (Glib), or TT for 30 days. Rats in group 1 were given sa...

Introduction: In 80–90% of cases, the cause of sporadic primary hyperparathyroidism is adenoma of one parathyroid gland. Multiple-gland disease (MGD) is defined in patients with more than one pathological parathyroid gland. The frequency of occurrence of MGD is from 7% to 33%.Our aim is to report a case of primary hyperparathyroidism with MGD and to describe its diagnostic and therapeutic features.Case Report: A 55-year-old man presented with 1-year...

Introduction: The quality of assay methods for HbA1c assessment has importantly improved last decades, however analytical interferences due to variants of hemoglobin remain of matter vigilance. Immunological interferences, although no longer described, may also occur.Observation: A 84-years-old woman without significant medical history was explored for polyneuropathy. Additional investigation as HbA1c was requested. As no value of HbA1c was obtained when...

Introduction: Thyroidectomy is a quite common procedure. Major postoperative complications of total thyroidectomy, including recurrent laryngeal nerve injur and hypocalcemia are not infrequent. The purpose of this study was to evaluate the incidence and risk factors of postoperative complications after total thyroidectomy.Methods: We retrospectively included patients who underwent total thyroidectomy over a period of 6 years. Hypocalcemia was defined as ...

Background: Polycystic ovarian syndrome (PCOS) is a multifactorial condition with metabolic-related complication, including chronic renal disorder, which is the leading cause of renal transplant globally. HDAC inhibitors (HDACi) have been suggested to protect renal function against biological assaults. Nonetheless, the current study investigated the restorative role of HDACi, butyrate in experimental PCOS-induced renal disorder.M...

A 57-year-old man presented with a 6-month history of worsening headaches and bitemporal hemianopia on visual field examination. MRI of the brain revealed a 3 cm pituitary lesion impinging the optic chiasm and indenting the pons. Appearances of the lesion on imaging and the patient’s normal anterior pituitary hormonal profile were highly suggestive of a non-functioning pituitary adenoma and this was the presumed diagnosis. The patient underwent trans-sphenoidal resection ...