Endocrine Abstracts

A 48-year-old male presented with headache, cough and recurrent nose bleeds. Clinical examination showed saddle shape nose deformity. His past medical history included primary hypothyroidism diagnosed at the age of 10 years, was taking levothyroxine. His brother had a Rathke’s cleft cyst, surgically removed. His blood test were as follows: Sodium 125mmol/l, TSH 0.10mU/l, free T4 10.2pmol/l, freeT3 2.6pmol/l, cortisol < 28nmol/l, prolactin 240mU/l, FSH 1.8U/l, LH 0.3U/...

A 45-year-old female developed clinical and biochemical recurrent Cushings’ Disease 2.5 years after transsphenoidal hypophysectomy for 2cm pituitary macroadenoma. Past medical history included Type 2 Diabetes mellitus, asthma, hypertension, grade 3 obesity, dyslipidaemia, depression and sleep apnoea. MRI showed residual pituitary tissue with left sphenoid sinus extension. MDT advised repeat transphenoidal surgery over radiotherapy due to presence of a clearly visible surg...

Background: Patient information leaflets are widely used by clinicians to reinforce and supplement information discussed during a consultation. This helps empower the patient and their family by enabling them to gain a greater understanding about their condition, investigation and/or treatment. However, despite the global increase in digital activity leaflets are still being disseminated in printed form. Accessing them online may be the more preferable option and would also mo...

Serum CA 19-9 (carbohydrate antigen 19-9) is a tumor marker of monosialoganglioside structure. Its level is frequently measured for screening purposes in daily practice by physicians, while its main use is in the study of tumor recurrence and follow-up of recurrences. Although significant elevations in CA 19-9 levels cause suspicion of malignancy, an underlying malignant disease may not always be determined and benign pathologies may also be seen. A 45-year-old female patient ...

Thyrotoxic periodic paralysis (TPP) is due to a fall in potassium levels and threat life if it effects respiratory muscles. Men are more effected than women, and lower extremeties are more prone to involvement. Serum potassium in hyperthroidism is usually normal, but Na+/K+ ATP’ase sensitivity is increased and extracellular potassium rapidly passes to the intracellular space. Beta blockers, small dose potassium replacement and hyperthyroidism treatme...

Introduction: Hyperthyroidism during pregnancy is a rare condition and occurs in 0.1–0.4% of all pregnancies. Graves’ Disease and transient gestational thyrotoxicosis constitute the majority of emerging thyrotoxicosis during pregnancy. Subacute thyroiditis (SAT) may also cause temporary hyperthyroidism.Case report: A thirty-three-year-old, 13-week pregnant patients was admitted with fatigue, pain and swelling in thyroid lodge. Thyroid function ...

Introduction: Adrenocortical carcinomas are rare aggressive tumors. 36 % of patients with ACC have distant metastasis on presentation. Although lung metastasis are commonly seen in metastatic Adrenocortical carcinoma, cannonball pulmonary metastasis which are solid and well circumscribed parenchymal masses of variable size are rare and typically seen in Renal cell carcinoma and also in other cancers such as bone sarcomas. We report a case of functional Adrenocortical cancer wi...

BackgroundHypothyroidism is a common disorder in elderly. Management of elderly population requires special attention since both undertreatment and overtreatment leads to increased mortality and morbidity. Normal ranges of TSH differs as patients get older and it is recommended as 4-6 mIU/l in patients older than 70–80 years. In this study we aimed to evaluate the TSH concentrations of elderly patients (75 years of age and older) who are under levot...

Objectives: The purpose of this study was to review the effectiveness of the Freestyle Libre flash glucose monitoring system at improving glycaemic control in a paediatric clinic.Methods: Data from 13 participants with type 1 diabetes for the first 3 months of use of the Freestyle Libre system either continuously or intermittently was collected using both clinic readings of glycated haemoglobin (Hba1c) and from the Libre itself using the Diasend diabetes...

Introduction: We aimed to investigate serum galanin-like peptide levels and its’correlation with hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS)Material and Methods: The study included 48 women (age range, 18-44 years) with a diagnosis of PCOS and control group that included 40 healthy females (age range, 18-46 years). Body mass index (BMI), waist circumference, Ferriman-Gallwey score, was evaluated and plasma glu...