Endocrine Abstracts

Purpose: Thyroid cancer is the most common cancer of endocrine system. Osteopontin (OPN) is a secreted glycoprotein that has a role in osteoblast differentiation and bone formation. Osteopontin has other roles in cell migration and cell survival and its related to tumorigenesis and cell invasion. Osteopontin levels have been determined higher in some malignancies. The purpose of this study is to determine plasma osteopontin levels in patients with new onset diagnosed thyroid c...

A 91-year-old lady presented with bradycardia ‘HR ~36, she was alert and conscious initially. Soon after the initial assessment, she was found unresponsive; with blood glucose of 0.8 mmol/l; bradyapnoec; BP 151/59; GCS 5/15; temp ‘32.8°C’. She was aroused after resuscitation with intravenous Dextrose, GCS 15/15 with an element of confusion, the temperature did not exceed 34.9°C despite active warming. The patient looked in a low mood, barely audible, w...

Introduction: Interaction of growth hormone system with Hypothalamic pituitary axis can be complicated, and the effect of GH treatment on thyroid function is still not completely clear. GH has inhibitory effect on conversion of T4 to reverse T3, while enhancing extrathyroidal conversion of T4 to T3.Objective: To assess thyroid function test in patients with growth hormone deficiency, receiving growth hormone replacement therapy in Slemani, Kurdistan regi...

Background: Thyroid disorders are among the common endocrine problems in pregnant women. Overt and subclinical hypothyroidism has been shown to be associated with an adverse outcome for both the mother and offspring.Objective: Are to find out the prevalence and complications of overt and subclinical hypothyroidism among pregnant Saudi women living at ALMadinah region.Materials and methods: A hospital-based prospective study perform...

BackgroundPapillary thyroid cancer (PTC), has a slow progression and good prognosis and is often treatable, but may show recurrence and metastasis. Age, sex, histopathologic variants of PTC, lymphatic or vascular invasion, lymph node involvement are among the factors affecting the occurrence of metastasis. Endocan is produced in vascular endothelial cells, epithelial cells lining the distal tubules of the kidney, submucosal glands of bronchus and lungs. ...

Case history: A 33 year old gentleman presented with a 4 month history of an evolving rash. This initially appeared on the extensor surfaces of the knees bilaterally and progressed to involve both arms and the trunk. This rash was not associated with fever, pain, pruritis or any other symptoms. These lesions were diffuse erythematous crops of yellow papules visible over the knees, arms and trunk. The patient was initially diagnosed with folliculitis and treated with oral flucl...

Hyponatraemia is the most common electrolyte abnormality, encountered in up to 30% of inpatients. Inappropriate management can have serious implications for patients; including demyelinating disease, coma, and death.Methods: Patients (n=100) admitted to the medical admission unit of a district general hospital with a serum sodium (Na) <130 were selected for the study. All details including patient demographics, blood biochemistry, date of admi...

Ovarian cancer is one of the major cause of death among women worldwide with high incidence. Ovarian cancer can be categorized into epithelial, non-epithelial (germ cell and sex cord-stromal cell), and metastatic (usually develop from surrounding cancerous organs). Recently, several approaches have been studied to control ovarian cancer at the transcriptional or post-transcriptional levels using small non coding RNAs including microRNAs. We carried out a meta-analysis of previ...

Polycystic ovary syndrome is a common endocrine disorder in women was associated with lipid disorders with increased risk of cardiovascular disease and obesity are associated. This study aimed to compare the lipid profile and fasting plasma glucose levels, insulin resistance in women with polycystic ovary syndrome is done with the control group.Methods: This case–control study on 153 women with PCOS and 449 healthy control subjects from 4 cities in ...

Background: Hyponatraemia is the most common electrolyte abnormality, encountered in up to 30% of inpatients. Inappropriate management can have serious implications for patients; including demyelinating disease, coma, and death.Methods: Patients (n=122) admitted to the medical admission unit of a district general hospital with a serum sodium (Na) <130 were selected for the study. All details including patient demographics, blood bio...