Endocrine Abstracts

Introduction: Brown tumor or osteitis fibrocystica is a benign bone lesion reflecting an abnormality of bone metabolism in the context of hyperparathyroidism. It can affect the entire skeleton, including the pelvis, ribs, clavicles and extremities. Involvement of the maxillary bone is very uncommon. We present a case of multiple brown tumors with an unusual maxillo-mandibular localization, revealed by a disorder of phosphocalcic metabolism and tertiary hyperparathyroidism. Thi...

Introduction: Digestive neuroendocrine tumors (DNETs) represent a heterogeneous group of tumors. This heterogeneity is manifested by the variable localization of these tumors but also by a great clinical and biological diversity. Thus, they occupy an increasingly important place in digestive oncology.NETs are very rare and represent about 1% of all digestive tumors, due to their slow evolution. The majority of them develop in the digestive tract (67.5%) ...

<table Introduction: Neurofibromatosis type 1 is a multi-organ genetic disease, commonly occurring with variable severity. Pheochromocytoma is a rare manifestation in NF1, affecting 1-15% of NF1 patients according to studies.Case Report: We present 2 cases: - Patient 1: 28 years old, with personal history of café au lait spots, cutaneous and subcutaneous neurofibromas, axillary lentigines. Referred for endocrinology consultation due to an adrenal m...

In Ireland, we are devolving management of diabetes to primary care. Recent studies highlight the importance of early glycemic (metabolic memory) & multifactorial control. Our hospital‘new’patient waiting lists average 18 months and for ‘best practice’, this is “time lost”. We established a pilot program for a rapid assessment to reduce waiting times and ensure specialist input. This is a retrospective review of our 50 patients thus far. 30% w...

Background: Post traumatic Hypopituitarism (PTHP) is common, its prevalence is about 30%.Aim: The aim is firstly to assess the frequency and predictive factors of hypopituitarism 3 and 12 months following Brain injury (BI) in a simple of 133 victims of moderate to severe BI in two neighbors’ hospitals in the east of Algiers. Secondly is to evaluate the quality of life and neurocognitive status of this cohort.Method: Hypopituit...

Grave’s disease is an auto-immune disorder which responds well to medication and up to half of the patients who take anti-thyroid drugs go into remission. We present a patient with Graves’ disease, who developed acute hepatitis associated with Carbimazole and, re-challenged with Carbimazole when she represented with in fast atrial fibrillation (AF) with relapse of hepatitis. A 75 year-old lady admitted with palpitation and chest tightness. She had a background of par...

Human bone marrow stromal cells (hMSC) contain a population of stem cells known as skeletal (mesenchymal) stem cells that are capable for differentiation into several mesodermal-type lineages including osteoblasts, adipocytes and chondrocytes. The aim of our research program is to understand the biological characteristics of hMSC so that it is possible to make full use of them in the context of clinical applications. The following topics will be discussed: i) approaches to iso...

The aim of this symposium is to introduce and to discuss current concepts regarding stem cells and their potential use in therapy with special focus on endocrinological applications. Stem cells are defined by their ability for self-renewal and multilineage differentiation. They are classified into embryonic and adult (tissue-specific) stem cells. Derivation, characterization and testing the functional activities of stem cells in vitro and vivo will be discussed. ...

Introduction: Dilated cardiomyopathy (DCMP) is a serious and rare complication of unrecognized chronic hypocalcemia, whose etiologies are dominated by hypoparathyroidism. The peculiarity of this DCMP is due to the fact that it is reversible to different degrees after the correction of hypocalcemia. Its incidence is rare because of the early management of any hypocalcemia. The objective of our work is to highlight the interest of screening and treatment of postoperative hypopar...

Background: Biological diagnosis of adrenal insufficiency (AI) is very difficult in the setting of critical illness like in traumatic brain injury (TBI), and the cut off defining AI need more precision.Aim: The aim is to assess the frequency and predictive factors of AI in a simple of 277 victims of moderate to severe BI in two neighbors’ hospitals in the east of Algiers.Method: Between November 2009 and December 2013, 277 pat...