Endocrine Abstracts

Introduction: The only curative treatment of primary hyperparathyroidism (pHPT) is surgery. Accurate pre-operative localization of abnormal parathyroid glands is an essential prerequisite to reduce the complication risk associated with surgery. We aimed to determine the diagnostic value of jugular venous sampling (JVS) in cases of pHPT in which the location of parathyroid adenomas could not be determined through various preoperative imaging studies.Metho...

Introduction: Primary hyperparathyroidism (PHPT) clinic occurs when the parathyroid glands secrete excess parathormone (PTH) due to hyperplasia, adenomatous or carcinomatous change. In the pathogenesis of the disease, dysregulation has been observed in extracellular signal-regulated 1/2 (ERK 1/2) pathways from the mitogen activated protein kinase (MAPK) family, c-Jun N-terminal kinase (JNK) pathways, and phosphatidylinositol-3 kinase (PI3K) pathways. Progranulin (PGRN) is a gl...

Introduction: Primary hyperparathyroidism (pHPT) is the third most frequently seen endocrine disease with autonomous overproduction of parathyroid hormone (PTH) in one or more parathyroid glands. It’s associated with osteoporosis, bone fractures, nephrolithiasis, renal failure and increased cardiovascular risk. We aimed to investigate the distribution of the clinical manifestations and biochemical features in patients with pHPT.Methods: A retrospect...

Objective: Obesity and vitamin D deficiency are become most important public health problems independently. We aimed to investigate the relationship between vitamin D levels and metabolic sydrome (MetS) in obese children and adolescents.Patients and methods: 51 obese children/adolescents at the age of 12.4±2.73 (7.0–18.0) years and 48 age–sex matched healthy controls were enrolled. Serum 25 OHD, 1,25 (OH)2 D, calcium, phosphorus, alkal...

Objective: To investigate the changes in serum creatine kinase (CK) levels during the treatment of patients with growth hormone (GH).Methods: We evaluated 715 cases who were treated with GH retrospectively. The clinical data of 20 children with severe CK elevation (>500 IU/L) were analyzed.Results: CK elevation was recorded in 96 of the cases (13.5%) during GH theraphy. 20 of these patients had severe CK elevation. The mean age...

Aim: Image-guided thermal ablation methods are gaining popularity in recent years for the treatment of benign and malignant thyroid nodules. It has also started to be performed more frequently in our country in the last few years, but few centers have published data on this subject. We aimed to assess the effectiveness and safeness of microwave ablation (MWA) technique in patients with benign thyroid nodules (TNs).Materials and Methods: This retrospectiv...

Introduction: Primary empty sella (PES) is often found incidentally during neuroradiological studies. Although pituitary function is usually normal in patients with PES, it could be associated with serious clinical conditions including different degrees of hypopituitarism. Post-operative empty sella (POES), the most common group, results from pituitary adenoma and their treatments. Our aim is to compare anterior pituitary functions and quality of life (QoL) with Short Form-36 ...

Introduction: The term congenital adrenal hyperplasia (CAH) encompasses a group of autosomal recessive disorders, each of which involves a deficiency of an enzyme involved in the synthesis of cortisol, aldosterone, or both. Deficiency of 21-hydroxylase, resulting from mutations or deletions of CYP21A, is the most common form of CAH, accounting for more than 90% of cases.Case report: Two female siblings were referred to endocrine clinic with the complain ...

Orexins, the novel pluripotent hypothalamic peptides, have been shown to exert important roles in the regulation of multiple physiological functions and behaviors including appetite, sleep and wakefulness and energy homeostasis through neural and endocrine mechanisms. Evidence emerging from recent research indicates that orexins may be involved in many other physiological functions. Our previous results have suggested that orexin-A and B activate Ca2+ signaling in c...

Up to date, many studies were performed regarding the relationship between obesity and inflammation, and exophthalmos which is developed in thyroid-associated ophthalmopathy (Graves’ ophthalmopathy). Several studies suggest that transforming orbital preadipocytes into adipocytes may cause exophthalmos because of the inflammation. Therefore, we examined the relationship exophthalmos and obesity which is also called low-grade systemic inflammation. We investigated the relat...