Endocrine Abstracts

It is known that treatment of prolactinomas with dopamine agonists is accompanied by relapses of the disease after discontinuation of the treatment in about 50% of cases and long-term or lifelong medication is required. The aim of the study was to evaluate the effectiveness of surgery in achieving remission or biochemical control of the disease. We prospectively enrolled 32 consecutive patients with prolactinomas who underwent transsphenoidal resection performed by the highly ...

Hurthle cell carcinoma (HCC) represents about 5% of differentiated thyroid carcinomas. When Hurtle cell represents more than 75% of cells population, the lesion can be considered a Hurthle cell tumor (HCT); it can be classify as malignant when capsular or vascular invasion is reported or if there is a perithyroid infiltration or distant metastases occur. Aim of this study was to present our own experience on the clinical and pathological features of patients (pts) affected by ...

Introduction: Cholesterol management is essential to prevent coronary artery disease (CAD) and related complications. Lifestyle changes are first treatment, followed by statin therapy. Multiple studies have shown statins to effectively reduce the risk of cardiovascular complications. LDL cholesterol is the main measure to assess impact of statin therapy. However, CAD risk also depends on other often neglected risk factors. We present preliminary data of the evaluation of the s...

Introduction: Weight loss is a cornerstone in the management of prediabetes and diabetes mellitus. The association between weight and all-cause mortality is controversial and even paradoxical. Studies usually assess baseline weight. Studies assessing weight changes over time are limited. We present preliminary results of our attempt to model weight changes in patients with prediabetes and diabetes assessing the relationship with all-cause mortality.Metho...

The age group under 45 years is the most difficult to determine the type of diabetes mellitus (DM), it can include type 1 (DM1), type 2 (DM2), MODY and LADA diabetes. Objective of the study: to determine clinical markers for differential diagnosis of types of DM in young patients.Materials and Methods: 202 patients with onset of diabetes aged 18 to 45 years were included: group 1 - 77 patients with MODY, 2 - 83 with DM 2, 3 - 14 with DM 1, 4 - 28 with LA...

Introduction: Hyperinsulinaemic hypoglycemia after gastric bypass surgery is a rare but probably underestimated complication. The mechanisms leading to hypoglycemia are complex and incompletely understood and involve several factors: A part from decreasing insulin resistance, caloric restriction and alteration of nutrient delivery, enhanced secretion of insulin and incretins (GLP1 and GIP), altered physiology of other hormones and dysregulation of counterregulatory effectors s...

Mesenchymal Stem Cells (MSC) are the source of regeneration of musculoskeletal tissues. Stem cells (SC) are rare and slowly dividing cells, situated in stem cell niches, regulated by non-stem-cell cap cells. Rare symmetric SC division regulates the SC pool. Asymmetric cell division gives rise to a transient amplifying pool (MSCTAP). The MSC niche is poorly characterized in contrast to MSCTAP and consecutive events of fate decision, commitment and secretio...

Paraganglioma (PGL) are rare neuroendocrine tumors with an estimated prevalence of 1:6500, with cardiac PGL being even rarer. Although most PGL are benign, approximately 15–35% of PGLs have metastatic disease, with few effective treatment options. Novel therapeutic indications, such as 177Lu-DOTA-TATE for patients with PGL, has been investigated in several clinical trials. A 66-year-old woman was referred to Cardiology in 2011 due to an incidentaloma adjacent to the right...

Evidence is accumulating that type 2 diabetes (T2D) is associated with cognitive impairment and dementia. In fact, numerous epidemiological studies have demonstrated that T2D patients have a significantly higher risk of developing neurodegenerative diseases and, in particular, Alzheimer’s disease (AD). In clinical practice there are no reported phenotypic indicators or specific examinations to identify T2D patients at risk of developing AD. This gap should be urgently bri...

Vasopressin acts through G protein-coupled receptors on the cardiovascular and renal system to induce vasoconstriction and antidiuresis. Vasopressin also has important functions within the CNS influencing cognition, olfaction and a range of complex social interactions and behaviours. In addition, vasopressin has been reported in the mammalian retina and here we investigated the location and expression of vasopressin and vasopressin receptors (V1a, V1b, and V2) in the rat retin...