Endocrine Abstracts

Aim: The work was initiated to study depression manifestations in patients with primary hyperparathyroidism.Materials and methods: Symptoms of anxiety and depression were assessed in 67 patients with primary hyperthyroidism aged from 16 to 30 years examined by means of Spielberger–Khanin’s test and Beck’s Depression Inventory.Problem of marginal psychoneurotic disturbances in patients with various somatic pathologies...

Aim: To study the effectiveness of metformin in treatment of polycystic ovaries syndrome (PCOS) in women of birthing age.Materials and methods: We followed 31 women with PCOS. Mean age of patients was 29.8 years old. All patients were evaluated for hormones levels (LH, FSH, TSH, estradiol, progesterone, testosterone, prolactin, coritsole, free thyroxine, dehydroepiahndrostendione etc.), glucose tolerance test, lipids profile, uterus and ovaries ultrasono...

Central obesity is strongly associated with insulin resistance and chronic sub-clinical inflammation, which is implicated in the development of type 2 diabetes (T2DM). However, the mechanisms underlying this link remain unclear. Recently JNK, a mitogen activated protein kinase (MAPK), has been implicated in obesity and insulin resistance by interfering with insulin action. Studies in rodent models show that phosphorylated JNK-1 is elevated in obesity, whilst the absence of JNK...

Introduction: Sex hormone-binding globulin (SHBG) regulates the bioavailability of sex steroid hormones, which in turn regulate reproductive function. The potential association of SHBG gene polymorphisms with the age at menopause has not been examined.Objective: The present study aimed to assess the possible relationship between the pentanucleotide (TAAAA)n repeat polymorphism in the promoter of the SHBG gene and the age at menopause in a Greek fe...

Background: Osteocalcin (OC) is a bone-specific protein produced primarily by osteoblasts during bone formation. The OC concentration is used to assess fracture risk and monitor treatment of osteoporosis and other disorders of bone metabolism. To adequately interpret the OC concentration, it is necessary to calculate reference ranges from a healthy reference population, adapted to a specific laboratory method.Methods: We established a healthy reference p...

Aim: To study tne quality of life of children with primary hyperparathyroidism (PHPT).Material and methods: 90 children with suspected PHPT were examined according to anamnesis, outpatient cards and surgical logs. The children were aged from 3 to 15 years old, who were treated in stationary conditions, and then were observed by us on an outpatient basis. 50 of them were treated surgically (1st group), 40 (2nd group) refused surgery ...

Objective: To Evaluate the effectiveness of parathyroidectomy in children with primary hyperparathyroidism.Materials and methods: Under our observation in the period 2014–2015, were 46 patients with primary hyperparathyroidism at the age of 11–16 years. To assess the effectiveness of parathyroidectomy a questionnaire was used and table PAS (Parathyreoidectomy Assessment of symptoms- table of symptoms in primary hyperparathyroidism to assess the...

With the cloning of the gene encoding pro-opiomelanocortin (POMC) it became apparent that several other peptides distinct from ACTH would be co-secreted from the anterior pituitary into the circulation. This begged the question as to whether these peptides have any biological actions on the adrenal, or to that matter any other tissue. Over the past two decades it has become apparent that the N-terminal fragment known as pro-gamma-MSH plays a role in adrenal physiology.<p c...

Aim: Somatic growth results from the generation of new support and connective tissue. Since collagen is the major protein constituent of connective tissue, its synthesis must be a prerequisite for the normal growth. The aim of the study was to determine age-related reference intervals for P3NP, a collagen – formation marker in a group of normal height prepubertal children and to compare to IGF1 levels.Subjects: Forty-three prepubertal children, male...

Introduction: Using discriminant analysis, a method based on two growth hormone (GH) dependent markers, insulin-like growth factor-I (IGF-I) and pro-collagen type III N-terminal peptide (P-III-P) has been devised to detect exogenously administered GH. It is believed that GH is a popular substance of abuse amongst adolescent athletes. As previous studies on the detection of GH abuse involved predominantly adult athletes, it is necessary to validate the method in adolescent athl...