Endocrine Abstracts

Background: SARS-CoV-2 profoundly impacts population health through both acute infection and post-COVID period. Multiple studies make it clear that metabolic diseases can significantly affect the course of COVID-19.Aim: To study the course of post-COVID period in patients with type 2 diabetes mellitus (DM2).Methods: The international registry ACTIV SARS-CoV-2 (NCT04492384) was established to study COVID-19 in the Eurasian region. T...

Background: The literature shows that body mass index (BMI) and blood glucose levels can significantly influence the course of infectious diseases. In the light of ongoing SARS-CoV-2 pandemic, its rational treatment and prevention are strategic public health goals.Aim: To study the relationship between BMI and serum glucose levels during the acute period of COVID-19 in hospitalized patients.«ACTIV SARS-CoV-2» registry was established to evaluat...

Devices for continuous glucose monitoring (CGM) measure interstitial glucose as a marker of changes in blood glucose. Although still lacking the accuracy of blood glucose meters, the CGM devices currently available have improved glucose control. The established technique of continuous subcutaneous insulin infusion (CSII) uses a portable electromechanical pump to mimic non-diabetic insulin delivery, infusing insulin at pre-selected rates. Essentially, a slow basal rate is achie...

Metabolic syndrome is an important social problem concerning a growing number of people. In different countries across Europe, its incidence is estimated at 17.4–28%. The metabolic syndrome is a constellation of risk factors for cardiovascular diseases. Hipothyreosis can additionally influence on lipid and carbohydrate disorders.The described study was a prospective, two-centre (A. Jurasz University Hospital No. 1 in Bydgoszcz, District Hospital in ...

Introduction: Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and HMG-CoA hepatic reductase, indirectly regulating the body’s lipid metabolism. This mechanism is already known, however the principles of regulating lipid metabolism through thyroid metabolism constitute an important and a desirable element of scientific research in thyreology. Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and...

One of the important proangiogenic factors involved in the growth of normal and neoplastic tissues is vascular endothelial growth factor VEGF.Therefore we hypothesized, that serum VEGF concentration would differ between patients with metastatic and non-metastatic thyroid cancer, with multinodular goiter and healthy subjects. We also hypothesized that endogenous TSH stimulation would effect serum VEGF level. The study protocol was approved by the Ethical ...

The aim of the study was to estimate the influence of a thyroid remnants’ volume, postsurgical concentration of thyroglobulin and radioiodine dose on the early treatment efficacy of well differentiated thyroid cancer.Material and methods: We retrospectively analyzed 91 patients (76 females, 15 men) with well differentiated thyroid cancer.Results: Histological classification revealed 68.1% (62/91) papillary thyroid cancers, 25....

Introduction: Obesity is the primary element of the metabolic syndrome, wherein one of the key reasons that heightens the risk of cardiovascular problems is the presence of liver fibrosis. Invasive core needle biopsy of the liver is considered the definitive method for diagnosing hepatofibrosis, however, non-invasive fibrosis indicators like FIB-4 are becoming more commonly utilized in routine clinical settings. Obesity can be defined in various ways, with the most prevalent m...

Introduction: Chronic autoimmune thyroid disease (ATD) or Hashimoto thyroiditis (HT) is one of the main thyroid diseases in pediatric age. HT characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function. Coeliac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects. At presents with a pathognomonic enter...

Continuous glucose monitoring (CGM) has highlighted the gap that exists between our expectations of tight metabolic control and the realities of actually achieving this, particularly during type 1 diabetes pregnancy. Longitudinal measurements indicate that despite overall ‘good’ HbA1c levels, pregnant women with type 1 diabetes spend 8 h/day with blood glucose levels above the recommended targets. New closed-loop (CL) or artificial pancreas approaches integrate insul...