Endocrine Abstracts

Aims: Genetic variations mediating matrix metalloproteinase-2 (MMP-2) expression may result in individual differences in susceptibility to particular diseases. Our aim was to investigate the possible association of certain MMP-2 gene variants with type 2 diabetes mellitus (T2DM) in a Tunisian population.Subjects and Methods: A case-control study involving 310 normoglycemic control subjects and 791 T2D patients was performed. A total of four MMP-2 SNPs (-...

Aims: Few studies investigated the association of genetic difference in metalloproteinase-2 (MMP-2) gene with diabetic retinopathy but with mixed outcome. The aim of the study is to investigate the association between a set of MMP-2 genetic variants and the risk of diabetic retinopathy in an Arab Tunisian population with type 2 diabetes.Subjects and Methods: A retrospective case-control study involving 779 type 2 diabetes patients with or without diabeti...

Background: Resistin is a recently discovered adipocyte-secreted hormone that links obesity with insulin resistance and/or metabolic and cardiovascular risk. This study was designed to investigate whether serum resistin concentrations constitute a significant coronary risk factor, with a particular focus on diabetes and one of its microvascular complications; nephropathy.Methodology: Serum resistin was measured in 86 overweight patients with acute corona...

Introduction: Anaplastic thyroid cancers are undifferentiated malignancies accounting for 2% of thyroid cancers.Objective: To study the clinical, evolutionary and therapeutic characteristics of these carcinomas.Materials and methods: A retrospective study covering 7 cases collected at our ENT department between 1994 and 2021.Results: They were 6 women and one man with an average age of 50 (41-78). The reason ...

Introduction: Secondary hyperparathyroidism is the main disorder of mineral and bone metabolism associated with chronic kidney disease. This disorder is characterized by hypersecretion of parathyroid hormone (PTH). Given the high cost and unavailability of calcimimetics, surgery remains a good alternative. In the immediate postoperative period after parathyroidectomy, hypocalcemia is common and close monitoring is critical.Objective: The aim of our work ...

Introduction: Hyperparathyroidism is the clinical and biological manifestation of excessive and inappropriate parathyroid hormone (PTH) production. It is the third most common endocrinopathy. It is often secondary to a single adenoma (80%). Occasionally, it may be a multi-glandular disease (15-18%). Treatment is surgical.Objective: the aim is to evaluate therapeutic results after surgery for primary hyperparathyroidism.Method: This...

Introduction: Hyperparathyroidism is the third most common endocrinopathy. Minimally invasive surgery using a unilateral approach is now increasingly common. In such cases, preoperative localization of the lesion by imaging is essential. Among the techniques available, ultrasound and scintigraphy play a predominant role.Objective: our aim is to evaluate the diagnostic contribution of ultrasound and parathyroid scintigraphy in localizing the pathological ...

Introduction: hyperparathyroidism is an endocrinopathy affecting calcium metabolism. Its curative treatment is surgical. Postoperative hypocalcemia is one of the main risks of this surgery.Objective: The aim of this study is to identify predictive factors of postoperative hypocalcemia after surgery for primary hyperparathyroidism.Method: This is a retrospective study including 84 patients operated on for pimary hyperparathyroidism ...

Introduction: Primary hyperthyroidism relates to the thyroid gland producing large amounts of hormone due to either uncontrolled growth of hormone-producing functional tissue. This condition needs to be treated surgically in order to prevent complications.Objective: The aim of this study is to describe the surgical treatment of primary hyperparathyroidism.Method: This is a retrospective study of 84 patients operated on for pimary h...

Introduction: Papillary carcinoma is the most common histological type of thyroid carcinomas. Lymph node involvement is an important prognostic factor. But its management remains uncodified.Objective: The aim of our study was to identify the predictive factors of lateral lymph node metastases in papillary thyroid carcinoma.Methods: This is a retrospective study including 96 patients operated on for papillary thyroid carcinoma at ou...