Endocrine Abstracts

Microplastics are one of the major pollutants over the globe jeopardising the health of aquatic life. The ecotoxicological effects of microplastics are well investigated in marine organisms, however, their impact on freshwater ecosystem remain unnoticed. Gastropod molluscs serve as good bioindicators for environmental toxicology. Therefore, we studied two commonly found freshwater snails, Lymnaea acuminata and Indoplanorbis exustus and checked the effect of m...

Introduction: Tc99m-Sestamibi+I-123 subtraction using planar and SPECT-CT (SPECT-CT 99mTc-MIBI parathyroid) is commonly used to investigate primary hyperparathyroidism (PHPT). We previously reported the sensitivity and positive predictive value of 4D CT parathyroid as the second line investigation in patients with non-diagnostic SPECT-CT 99mTc-MIBI parathyroid (https://www.endocrine-abstrac...

Introduction: Tc99m-Sestamibi+I-123 subtraction using planar and SPECT-CT is commonly used to investigate PHPT. Our centre previously published sensitivity and specificity of 92 and 86% respectively for Tc99m-Sestamibi+I-123 subtraction. Five false-negative studies required neck exploratory surgery. One false-positive study incorrectly localised a PA which was not found in surgery (n=67). In recent years 4D-CT parathyroid has emerged as a useful technique to detect an...

Primary hyperparathyroidism (PHPT) is rare in pregnancy, with an incidence of 1%. It is associated with maternal, fetal, and neonatal complications. Treatment options include both medical and surgical approaches. Parathyroidectomy is the definitive and preferred treatment, especially when serum calcium level is higher than 10.8 mg/dl and with a prior history of pregnancy loss. Herein, we present two cases of gestational primary hyperparathyroidism with different treatments.</p...

Introduction: Hirsutism affects 10% of the female population caused by hyperandrogenism of benign aetiologies or androgen-secreting tumours. Tumorous causes of hyperandrogenism include androgen producing ovarian or adrenal tumours. Leydig cell tumours are rare ovarian testosterone producing tumours that comprise 0.1% of total ovarian tumours. It is rare in postmenopausal women and present with features of hyperandrogenaemia or hyperestrogenemia.Case: We ...

Introduction: Obesity was thought to be protective against osteoporosis, but studies have shown conflicting results. We analysed the cross-sectional data from the National Health and Nutrition Examination Survey Data (NHANES) survey (2008–2012) to observe the association between BMI (BMI and/or waist circumference) and bone mineral density (BMD) at the femoral neck.Research methods and design: We categorised the study population (women aged 50 years...

Adrenocortical carcinoma (ACC) is a rare malignancy associated with a poor prognosis (1). Current treatments are limited with surgical resection the only option for a complete cure (2). The development of translational therapies is limited by pre-clinical disease models. Three-dimensional (3D) cell culture models can accurately reflect the tumour micro-environment but are lacking in ACC (3). In the current study, we developed and characterised novel 3D models of MUC-1, HAC15 a...

Subpopulations of beta cells dictate overall ‘pacing’ of insulin secretion across the islet and therefore the control of glycaemia. Functional beta cell subpopulations also exist in human islets and have an altered subtype distribution in type 2 diabetes. However, the molecular control of the establishment and maintenance of beta cell hierarchy is poorly understood. We hypothesised that the epigenome would govern this heterogeneity. We have identified a novel subpopu...

Introduction: To date, few cases with both congenital hypopituitarism (CH) and hyperinsulinaemic hypoglycemia (HH) have been reported in the literature. We now report a cohort of 12 cases with CHI associated with HH.Clinical Phenotype: An association between congenital hypopituitarism (CH) and hyperinsulinaemic hypoglycemia (HH) was present in 12 patients (M:F 9:3). Mean age at diagnosis of HH was 0.9 months, whereas mean age at diagnosis of CH was 2.0 y...

IntroductionDapagliflozin is sub-optimally utilised in the real world. There is a lack of a comprehensive collaborative guidance for a practical approach to manage patients with cardiometabolic, renometabolic and viscerometabolic disorders. Patients across the CRV-M continuum includes patients with varied clinical profiles.MethodsTwo round Delphi study was conducted using a virtual online-digital connect appr...