Endocrine Abstracts

The incidence of children presenting with DKA at diagnosis has been on the rise worldwide1. 25.8% of newly diagnosed children had DKA at diagnosis according to the NPDA report (2020/21). 34% of newly diagnosed children in the Yorkshire and Humber(Y&H) region presented in DKA2. Delayed presentation due to lack of awareness is a likely cause for that.Aim: To review the presentations of DKA at diagnosis in the YH r...

Introduction: Lipodystrophic syndromes are a heterogeneous group of congenital or acquired disorders characterized by either complete or partial lack of adipose tissue. Other prominent abnormalities of these disorders include Diabetes Mellitus and acanthosis nigricans due to the associated insulin resistance. Liver affection is common due to fatty infiltration of the liver, which can lead to cirrhosis and its complications.Clinical case: A 31 years old s...

Background: High prevalence of thyroid disorders is more common in T1 compared to T2 Diabetes Mellitus due to the associated autoimmunity, with hypothyroidism being the most common disorder.Objectives: The aim of this study is to assess the prevalence of autoimmune thyroid dysfunction among T2 diabetic Egyptian females and to find the correlation between the metabolic syndrome components and autoimmune thyroid dysfunction.Methods: ...

There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. A comprehensive literature search found 91 studies linking BPA to human health; 53 published within the last year. This body of literature is showing associations between BPA exposure and adverse perinatal, childhood, and adult health outcomes, including reproductive and developmental effects, metabolic dise...

The normal development of the female reproductive tract depends on the interaction between genetic, hormonal and environmental factors for the differentiation of the Müller and Wolff ducts, and the urogenital sinusCase report: 16-year-old female, single, school student presented to our endocrine department complaining of primary amenorrhea. No history of chronic diseases, excessive exercise,medications, anorexia, clinical hypothyroidism or hyperandr...

A retired 73 year old teacher, who had 2 sons and lived independently alone and stayed active playing tennis 3 times per week. She is an ex-smoker and drinks alcohol occasionally. Past medical history: right breast cancer T1N0 post wide local excision/radiotherapy in remission, type 2 diabetes on Linagliptin. Large cell neuroendocrine tumour of the lung with liver metastasis, on palliative chemotherapy with Octreotide injections. Admitted with generalised body weakness started...

Introduction: Type 2 diabetes mellitus, has gained a lot of attention in recent years as one of the most important chronic progressive diseases in the world, which slowly crawls towards longevity and which involves many chronic complications, which are dangerous to health and the economy. Sodium-glucose cotransporter-2 (SGLT2) inhibitors represent a category of newly discovered drugs that work by preventing glucose reabsorption in the proximal renal tubules. (SGLT2) Inhibitors...

Introduction: Diabetes mellitus is not just a disease as it is already known, the matter is more complicated, and it is considered as an assembly of metabolic defects with end result of hyperglycemia. verapamil can decrease the expression of thioredoxin-interacting protein (TXNIP), which is recognized as an important factor in pancreatic beta cells. verapamil could enhance beta cell mass and function.Materials and methods: 160 type 2 diabetes mellitus an...

In order for type 2 diabetes to occur, insulin resistance occurs first, which often occurs from an increase in fat deposition in the liver and the pancreas, and with this resistance. It is universally agreed that diabetes diagnosis is by analyzing blood glucose. The ultrasound technology often helps in diagnosis and quick decision-making in the treatment of many diseases. It can tell us about the muscles’ echogenicity.Materials and Methods: 400 pati...

Introduction: Many researchers are linking diabetes with obesity, which has become very prevalent now, but we see large numbers of diabetics with normal weight as we see obese persons, but they are not necessarily diabetics, which calls us seriously to review this matter, taking into account that obesity is a factor in the occurrence of diabetes. Many studies have talked about visceral fat, as well as about the ratio between visceral fat and subcutaneous fat and its role in th...