Endocrine Abstracts

Background and Aim: Potential adverse effects of metabolic surgery on skeletal integrity remains an important concern. Bone loss is common after surgery due to multiple factors including vitamin D deficiency, altered calcium metabolism, mechanical load reduction and hormonal pattern changes. It is still not clear if the effects on bone health and calcium homeostasis vary according to each surgical technique. Further, long-term data of different surgical approaches are poor. Th...

Background: Osteogenesis imperfecta (OI) is a heritable disease of the connective tissues caused primarily by heterogeneous mutations in the genes encoding for type I collagen. Phenotypically, it is characterized by abnormal bone mineralization, tissue fragility, and skeletal deformities.Objective: The aim of this study was to investigate the osteoclastogenic potential of unfractionated peripheral blood mononuclear cells (PBMCs) from OI patients (mean ag...

Background: Obesity and in particular visceral adiposity has been related to low bone mineral density (BMD) and greater fracture risk. Subjects with Prader–Willi syndrome (PWS) have lower amount of visceral fat than patients with simple obesity, however can develop osteoporosis. A strong relationship between inhibition of the osteoblast formation and induction of the adipocyte differentiation has been demonstrated. Inhibitors of osteoblastogenesis, such as Dickkopf-1 (DKK...

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease and Post-surgical HypoPT (PS-HypoPT) is the most common cause, caused by accidental parathyroid injury. From a neuropsychological standpoint, patients with PS-HypoPT present cognitive and neuropsychological symptoms. Irisin is a myokine secreted by contracting muscle, which mediates beneficial effects on several targets, including brain. The aim of this study was to evaluate irisin in the context of PS-HypoP...

Introduction: Cerebral palsy (CP) is the most common chronic disability in childhood, burden by motor, sensation, cognition, feeding and communication impairment. A serious concern in children with CP is bone/muscle health deterioration, which negatively impacts the already reduced quality of life (QoL). Irisin is a myokine secreted by contracting muscle, which mediates beneficial effects on several targets, including brain. The aim of this pilot study was to evaluate serum le...

Background: The incidence of differentiated thyroid cancers is increasing, mainly due to the overdiagnosis of small papillary thyroid cancers (less than 1 cm, previously known as microcarcinomas). There is a broad consensus in reducing the surgery extent and the use of radioiodine treatment in low-risk cases by most recent clinical practice guidelines focusing on thyroid cancer treatment. The adoption in real clinical practice is usually slow. The aim of this study is to estim...

Disturbed oestrogen homeostasis is associated with an increased risk of cardiovascular disease. However, the impact of dysregulated oestrogen signalling on vascular development, maintenance and disease is not fully understood. Zebrafish is a well-established model in translational vascular research. In addition, oestrogen receptor expression and oestrogen-responsiveness in endothelial cells (EC) is conserved in zebrafish. Therefore, the aim of this study was to characterise th...

Autoimmune polyglandular syndrome type 2 can be associated with alopecia areata. We present herein a case of a female patient, 42 years old, who suffered from autoimmune thyroid disease with hypothyroidism and autoimmune adrenalitis and who was recently diagnosed with alopecia areata. She accused sudden, asymptomatic hair loss, which she noticed 3 months ago, accompanied by a burning sensation in her scalp. Her menstrual cycles were normal. The clinical examination identified ...

Background: AIT type 2 is self-limiting in nature and therefore discontinuation of amiodarone may not be necessary; however, the feasibility of continuing amiodarone has never been tested formally. Potassium perchlorate (KClO4) may have advantage when prednisone is unsuccessful in AIT type 2, possibly due to mixed cases of types 1 and 2. KClO4 also mitigates the cytotoxic effect of desethylamiodarone on thyrocytes in vitro.Ob...

Introduction: Currently, type 1 diabetes (T1D) is defined by the autoimmune destruction of the pancreatic β cells that culminates in dependence on exogenous insulin, typically 1–3 years after diagnosis. This ability to maintain a residual function of pancreatic β cells is, however, heterogeneous, appearing to be worst if the disease is early diagnosed. Recently, it was demonstrated that many type 1 diabetic patients produce small amounts of insulin decades after...