Endocrine Abstracts

Background: Non-classic adrenal hyperplasia (NCAH), comparatively a rare disease, is characterised by mild to moderate hyperandrogenemia, hirsutism, oligomenorrhea, insulin resistance which incidentally are the hallmarks of polycystic ovary syndrome (PCOS)- a common disorder among reproductive aged women. The data on 17-hydroxyprogesterone (17-OHP)serum levels in NCAH has been reported globally but there is limited data available regarding the normal range among healthy Indian...

Section 1: Case history: A 19-year-old Caucasian female presented to the A&E department with a head injury following a road traffic accident. A CT head done to exclude head injury was normal but incidentally showed a significant pituitary macroadenoma and she was referred to endocrinology as out-patient urgently. This was delayed by 4 months due to face-to-face clinics being suspended in the first wave of the pandemic. Virtual consultation revealed a history of headaches f...

Aims: The short synacthen test (SST) is considered as the gold standard test to assess the viability of the hypothalamic-pituitary-adrenal axis. This study explores the appropriateness of its clinical use in a district general hospital. Furthermore, it assesses the effectiveness of the alternate use of 9AM cortisol in excluding hypoadrenalism and the cost-effectiveness of sampling both 30 and 60 minutes serum cortisol in SST.Me...

Aims: The short synacthen test (SST) is considered as the gold standard test to assess the viability of the hypothalamic-pituitary-adrenal axis. This study explores the appropriateness of its clinical use in a district general hospital. Furthermore, it assesses the effectiveness of the alternate use of 9AM cortisol in excluding hypoadrenalism and the cost-effectiveness of sampling both 30 and 60 minutes serum cortisol in SST.Me...

Background: The intrauterine foetal environment is crucial for its survival and long term health. Intrauterine growth retardation of the foetus is a pregnancy specific disorder which involves the restriction in the physical and or mental growth of the foetus during the course of the pregnancy. Lactate dehydrogenase is an intracellular enzyme that converts lactic acid to pyruvic acid. It has been proposed as an important marker for liver diseases, myocardial, renal, and pulmona...

Introduction: US Food and Drug Administration (FDA) has recently approved bexagliflozin, a new SGLT2 inhibitor. We examined the outcomes and metabolic effects of Bexagliflozin across the published Randomised Controlled Trials (RCCTs)Methods: A comprehensive literature search was done to extract publications from Medline-PubMed and Cochrane library, since inception till January 20, 2023, then screened and reviewed by two independent reviewers. Data includ...

Background: Millions of people worldwide take an intentional nap or siesta after lunch, but data describing potential health effects of naps are very limited. We report on associations between napping and metabolic syndrome risk in a large older Chinese group.Methods: Data from 16 480 older participants (≥50 years) from the Guangzhou Biobank Cohort Study were analysed. Sociodemographic parameters, including frequency of lunch-time napping were coll...

Objectives: Thyroid eye disease (TED) is considered a fibroinflammatory disease with pathology related to both inflammatory and fibrotic disease processes. IL-11 is a fibroinflammatory cytokine that is linked to tissue fibrosis of the lung, skin, heart, kidney and liver. Recently, IL-11 was identified as a possible disease modifier in TED. IL-11 levels are increased in TED patient plasma, in correlation with disease severity, and IL-11 stimulates phenotypic switching of orbita...

A 20 year old man otherwise fit and well, presented with a seizure, fall and fractured neck of femur. DEXA scan revealed osteoporosis; baseline blood tests were apparently normal in the endocrinology clinic with a Testosterone level of 24.3 nmol/l (Range 9.9–27.8) and normal bone and thyroid profile. He was then lost to follow-up. 4 years on, he was re-referred to the endocrinology clinic with a surprisingly elevated testosterone level of 34.6 nmol/l in combination with o...

Morphologically, the follicular cells of the thyroid gland on the background of chronic lymphocytic (Hashimoto) thyroiditis may exhibit atypical changes in the nucleus, expansion of the nucleus, crowding, irregularities of nuclear membranes, intranuclear grooves and purification of chromatin. Also be observed proliferative foci of thyroid follicular cells with follicular epithelial dysplasia (FED) were as presumed premalignant conditions in chronic lymphocytic thyroiditis. The...