Endocrine Abstracts

Large adrenal masses are strongly suggestive of malignancy. Nevertheless, bilateral adrenal masses are less common (around 20% of incidental adrenal lesions). Metastases and lymphoma are more frequent (especially when aging), and not so easy to differentiate on CT or MRI. Simple biological markers, such as plasma LDH or beta2microglobulin, could help.Case report: A 69-year-old patient was admitted for abdominal pain with progressive lethargy. Abdominal C...

Introduction: Primary adrenal lymphoma is rare, representing less than 1% of non-Hodgkin lymphomas.1 The clinical presentation is non-specific, symptoms of adrenal insufficiency may occur with bilateral lesions, and work up can be tricky.2Background: A 60-year-old man was admitted mid-January 2020 for acute left abdominal pain. He had no medical history and didn’t smoke or take any medication. He had no history of recent trauma...

Cases of hyperthyroidism manifestation associated with previous secondary hypothyroidism are extremely rare. The article presents a rare clinical case of Graves’ disease manifestation in a patient with secondary hypothyroidism after radiosurgical treatment of acromegaly. A 38-year old woman with acromegaly and endo-supra-laterosellar pituitary adenoma had transsphenoidal non-radical surgery and subsequent radiosurgical treatment. After 2 years of radiation treatment, she ...

Thyroid dermopathy or pretibial myxedema (PTM) is a rare extrathyroidal manifestation of Graves’ disease with diverse presentations. Therefore, information on the clinical data of PTM patients is scarce. In this study, we aimed to evaluate the clinical features of patients with thyroid dermopathy and Graves’ disease. A total of 43 patients with pathologically confirmed PTM were retrospectively recruited. According to the diagnosis, the clinical data and laboratory fi...

Superoxid dysmutase (SOD) is a key antioxidant enzyme engaged in detoxication of superoxide radicals. Ala/Val substitution in Mn SOD leads to a change in the effectiveness of the action of the enzyme. This polymorphism we analyzed among several groups patients with diabetes and we compared with control group of healthy volunteers. It is proved an association connection of tracked marker in some of the groups of patients with diabetes compared to the rest population sample. Suc...

Background: Osteoporosis has been an excruciating disease for many years now. Although various treatments are available, there is an unmet need for disease prognosis, early disease diagnosis and prediction of treatment efficacy. New biomarkers are crucial for the diagnosis or prognosis of a disease as well as for monitoring treatment efficacy and improve decision making. Cathepsin K is a cysteine protease that cleaves collagen type I, the major type of collagen found in bone, ...

We report a 53-year-old man. At age 3, the patient was diagnosed with chronic mucocutaneous candidiasis. At age 41 the patient started losing all hair on the body with total boldness. At age 43, he first complained of muscle weakness resulting in difficulty walking, back pain and difficulties holding his head in an upright position. At age 49, he was diagnosed with chronic primary adrenal insufficiency and hypoparathyroidism. Genetic analysis confirmed APS-1 (c.769C>T p.R2...

Introduction: Woodhouse-Sakati syndrome (WSS) is a rare autosomal recessive disorder characterized by diabetes, hypogonadism, hypothyroidism, sensorineural hearing loss, alopecia totalis, extrapyramidal findings and specific changes on ECG. This syndrome belongs to a heterogeneous group of neurodegenerative disorders and is caused by mutations of the DCAF17 gene. Treatment is symptomatic and patients are managed by multidisciplinary teams. About 90 cases were reported since 20...

Background and objective: One of the key features of thyroid gland cancer evaluated at palpation is the degree of firmness: malignant lesions tend to be much harder than benign ones. US elastography is combining the diagnostic advantages of high-frequency US examination and the accuracy of thyroid cancer diagnosis based on the lesion’s stiffness. The aim of our prospective study was to evaluate the elastographic appearance of thyroid gland tumours and to explore the sensi...

The aim of the research is to study the functional state of liver parenchyma in patients with type 2 diabetes and to analyze hepatobiliary system disorders depending on marker of metabolic syndrome (MS).The study involved 22 patients with type 2 diabetes and MS and 8 healthy persons. Dynamic hepatoholecystoscintigraphy was performed using RKC 301T gamma camera after Tc-99m mesida administration and bile-expelling meal.We establishe...