Endocrine Abstracts

Background: Preeclampsia (PE) is a multifactorial and multisystem disorder, with unknown pathophysiology, but factors such as defective trophoblast invasion and narrowing of spiral arteries may be contributing to the onset of PE and affecting mother and foetus development. Early prediction of PE may improve the surveillance and prognosis of hypertension in pregnant women in preventing associated complications. Therefore, it is essential to find markers for the detection of PE ...

Objectives: Somatotropinomas form three subgroups with distinct methylation profiles1, one matching the sparsely granulated (SG) and the other two matching the densely granulated phenotypes (DG-A and DG-B). Publicly accessible raw methylation data1 and our RNA microarray data were analysed to identify differentially methylated regions (DMRs) and enriched genes between SG, DG-A and DG-B and normal anterior pituitary gland (NP), genes showing differential m...

Objectives: Somatotropinomas can be divided into three subgroups based on their distinct DNA methylation profiles1, one matching sparsely granulated (SG) and the other two matching densely granulated phenotypes (DG-A and DG-B). Sparsely granulated adenomas show fibrous body formation on cytokeratin immunohistochemistry, compared to diffuse staining in densely granulated adenomas. Methylation1 and gene expression data were analysed to identify (i) differen...

Introduction: Chronic liver disease (CLD) is usually not described as a common cause of hypercalcemia unless there is hepatoma. Of late, there are some reports suggesting CLD as a cause for hypercalcemia. The exact mechanism contributing to hypercalcemia in CLD is poorly understood. It usually correlates with the severity of disease.Aim of the study: To assess the prevalence of hypercalcemia in patients with chronic liver disease To study the relation of...

Background: Preeclampsia (PE) continues tochallenge both the clinicians and researchers worldwide, as the existing knowledge on its etiopathology does not come up with an efficient and foolproof treatment regime due its progressive nature and uncertain diagnosis and prognosis. In this context, miRNAs represent a potential therapeutic target and a diagnostic tool.Objectives: Circulating microRNAs present in maternal blood play an important role in the eti...

Background: Gigantism is a rare condition with accelerated growth in childhood when the epiphyseal plates are not fused. Most cases are due to growth hormone (GH) secretion from a pituitary adenoma. Rarer causes of GH-related gigantism include somatotroph hyperplasia as part of McCune-Albright syndrome, Carney complex, X-linked acrogigantism or ectopic GHRH production.Case presentation: An 18-year-old male with c.249_252delGTCT;p.I85Sfs MEN1 mut...

Aims: To assess the incidence of Ipilimumab associated hypophysitis and its common presentations.Methods: All patients who developed Ipilimumab induced hypophysitis following treatment for Malignant melanoma at a large tertiary care centre in West Midlands, United Kingdom from 2012 to 2014 were included in the study. Patients with known pituitary disease prior to treatment and/or received other systemic immunotherapy following Ipilimumab treatment were e...

Introduction: Lipodystrophy is a rare disease that can present with a broad range of symptoms. Delays in diagnosis are common, which in turn, may predispose to the development of severe metabolic complications and end-organ damage. Many patients with lipodystrophy are only diagnosed after significant metabolic abnormalities arise.Aim: Prompt action by clinical teams may improve disease outcomes in lipodystrophy. The aim of the Rapid Action Plan is to ser...

Approximately 10% of the female present with features of hyperandrogenism in their life. It is common in adolescent and childbearing age and less common in menopausal age. A 56-year-old female with a history of type 2 diabetes mellitus, hypertension presented with progressively worsening features of virilization for 1 year. Patient had severe hirsutism, androgenic alopecia and clitoromegaly. She had no loss of weight, loss of appetite suggestive of underlying malignancy. Howev...

Parathyromatosis is a persistent or recurrent hyperparathyroidism following parathyroidectomy. It usually presents as multiple nodules in the neck. Infrequently may present as a single palpable neck mass. It could be due to low grade malignancy, seeding of parathyroid tissue during parathyroidectomy and growth of persistent embryonic foci of parathyroid tissue. A 24-year-old patient presented with features of hypercalcaemia. She has undergone left inferior parathyroidectomy 1 ...