Endocrine Abstracts

Introduction: Calcitonin (CT) is the most specific marker for medullary thyroid carcinoma (MTC), thus, even low detectable values can conceal persistent disease. Current guidelines suggest performing an early CT evaluation three months after surgery. However, this timing may be too premature to evaluate the CT nadir, since different isoforms or aggregates from tumour deposits may persist in the bloodstream and require additional time to be cleared. The present study aimed to e...

Introduction: Indeterminate cytology still puzzles clinicians, due to its wide range of oncological risks. The new Italian cytological classification introduced in 2014 by SIAPEC-IAP split this category into TIR3A and TIR3B, according to a different cancer risk of <10% and <30%, respectively. Consequently, TIR3B nodules still have a surgical indication, even if more than half of cases will not result in thyroid cancer. The present study aims to analyse a consecutive se...

Background: Diabetic Ketoacidosis (DKA) is a well known complication in children with Type 1 Diabetes (T1DM) with a mortality rate estimated at 2%. Sparse data is available from the literature describing socio-demographic factors associated with DKA admissions in children. A previous study identified that children of non-Caucasian race and Medicaid, with T1DM, had increased incidence of DKA admissions.Aims: To identify the socio-demographic factors assoc...

Background: Diabetic ketoacidosis (DKA) is a well-known complication in children with type 1 diabetes (T1DM) with a mortality rate estimated at 2%. Sparse data are available from the literature describing socio-demographic factors associated with DKA admissions in children. A previous study identified that children of non-Caucasian race and Medicaid, with T1DM, had increased incidence of DKA admissions.Aims: To identify the socio-demographic factors asso...

Diabetes is mainly a consequence of the lifestyle of the current population, characterized by an increase in obesity, sedentarism and a highly caloric diet, added to which is an ageing population. Prevention and its treatment consist in following an adequate diet, practising physical exercise regularly and maintaining normal weight, factors which are achieved through the adoption of healthy lifestyles. However, weight loss remains a problematic issue among diabetics, mainly du...

Summaries: Treatment adherence in Type 2 Diabetes: Experimental study research project Diabetes is a metabolic disease brought about by high levels of glicose in the blood over a long period of time. It’s a disease which shows an increasing incidence, mainly in developed countries. When untreated, diabetes can cause several acute complications, such as ketoacidosis, hyperglycemic hyperosmolar state or even death. Prevention and treatment consist in ...

Background: Patients with hypoparathyroidism require frequent calcium measurements and currently there is no point of care device allowing this to be done at home by patients themselves. The aim of our study was to evaluate whether ionized calcium(iCa) can be accurately measured in venous and capillary blood and saliva by a repurposed device LAQUA.(R&D Ref 18/0058– IRAS 236079)Methods: Patients undergoing thyroid and parathyroid surgery underwen...

EEC is a multisystemic disease secondary to a clonal histiocyte proliferation of non-Langerhans cells due to hyperactivation of the MAPK/ERK signaling pathway, with somatic BRAF V600E mutation present in 50% of cases with therapeutic implications. Between 50% of patients develop endocrinopathies, the most frequent being central diabetes insipidus (CDI). We present the case of a 42-year-old woman, diagnosed with CDI in 1998 without family history, treated with DDAVP [MRI: absen...

Introduction: Thyroid cancer is the most common endocrine malignancy, and its incidence is increasing worldwide.Objective: Our aim is to look at the prevalence of ultrasound features and FNA findings of nodules in patients operated on for thyroid cancer in our hospital.Material and methods: Cross-sectional observational study of patients operated on for thyroid cancer at the Regional University Hospital between 2018-2021, we collec...

Introduction: medullary thyroid carcinoma (MTC) is a neuroendocrine thyroidal cancer. World Health Organization recognizes a grading system for almost all neuroendocrine tumors; however, a shared grading system for MTC is still lacking. We performed a clinical and pathological review of 257 MTCs to evaluate which histologic features have an impact on the disease specific survival and to propose a new grading system.Method: We retrospectively reviewed cli...