Endocrine Abstracts

Objective: Previously, we identified that knockdown of calcium/calmodulin-dependent serine protein kinase (Cask) in β cells in vitro resulted in decreased insulin secretion. We then used the Cre-loxP system to specifically delete the Cask gene in β cells of mice, and the mice exhibited impaired glucose tolerance and glucose-stimulated insulin secretion under a normal chow diet. However, under a high-fat diet (HFD), the insulin sensitivity a...

Purpose: Recently, apatinib, an orally anti-angiogenic tyrosine kinase inhibitor (TKI) is reported to be useful for treatment of progressive RAIR-DIC. The aim of this study was to evaluate the effect of apatinib and the combination therapy with radioactive iodine (RAI) in patients with progressive metastatic DTC.Methods: Five patients (all female mean age 62 ± 8 years, ranged from 51 to 69 years) with progressive distant metastatic DTC (dmDTC) after t...

Endocrine-Related Cancer, 2019, 27(2): 81–95 (DOI: https://doi.org/10.1530/ERC-19-0095)...

A genome wide meta-analysis by the CORtisol NETwork (CORNET) consortium1 has identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with changes in morning plasma cortisol and predictive of cardiovascular disease (Crawford et al, Unpublished). SERPINA6 encodes Corticosteroid Binding Globin (CBG) which binds most cortisol in blood and influences delivery of cortisol to target tissues. We hypothesised th...

Context: Distinct differences of clinical manifestations exist in hypertensive pheochromocytomas (HPs) and normotensive phaeochromocytomas (NPs), however the comparative analysis is lacking.Objective: The objective of the study was to assess the clinical symptoms, haemodynamics, metabolism, radiological and histological features of patients with HPs and NPs.Research design and methods: This retrospective study included 104 patients...

Erythropoietin, testosterone and growth hormone are drugs of choice for those athletes wishing to gain a competitive advantage as they are most difficult to detect using the current anti-doping methods. The illicit use of such substances violates the spirit of clean sport and fair competition. Since its formation in 1999, the World Anti-Doping Agency (WADA) has been responsible for drug testing. Direct detection of substances complemented by the indirect Athlete Biological Pas...

Objective: Successive female pseudohermaphroditism born to gestational hyperandrogenism accompanied by maternal virilization is extremely rare in literature.Patient(s): A housewife, age 29, G2P1A1, revealed no hyperandrogenism before pregnancy. She gave her first child birth complicated by maternal virilization and female fetal pseudohermaphroditism due to hyperandrogenemia of bilateral 6-cm ovarian luteoma at age 27. Peak maternal serum testosterone lev...

Background: Epithelial-mesenchymal transition (EMT) plays a key role in tubulointerstitial fibrosis, which is a hallmark of diabetic kidney disease (DKD). Our previous studies have shown that CRTC2 can regulate glucose metabolism and lipid metabolism at the same time. However, it is still unclear whether CRTC2 participates in the EMT process of DKD.Methods: We used protein-protein network (PPI) analysis to determine differentially expressed genes in DKD ...

Abstract: There are a growing number of studies identifying secretin as a neuroprotective factor. Consistently, our previous data showed that neuronal apoptosis considerably increased in the developing cerebellum from secretin knockout (Sct-/-) mice. However, the underlying mechanisms remained poorly understood. Extracellular signal-regulated protein kinase (ERK) and AKT signalling pathways are known for the regulation of apoptosis. Additionally, these two pathways could activ...

Previously, we demonstrated that progesterone (P4) could enhance breast cancer cell migration through increasing formation of the p27-RhoA complex and RhoA activation caused by the cSrc/AKT-mediated phosphorylation of p27 at T198. Here, we further examined the effect of P4 on breast cancer cell proliferation. Our results show that P4 (12.5–100 nM) concentration-dependently enhanced proliferation in breast cancer cell lines (T47D and MCF-7). We also found that increases of...