Endocrine Abstracts

Introduction: Prader–Willi syndrome is a genetic disorder characterized by hypotonia, intellectual disabilities, obesity and behavioral disturbance. Patients present with several neuroendocrinological abnormalities, such as growth hormone deficiency, hypogonadotropic hypogonadism, and hyperphagia, as the result of possible involvement of the hypothalamo-hypophyseal system. Diffusion tensor imaging (DTI) is a noninvasive MRI technique capable of providing quantitative indi...

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Introduction: Obesity is a cause of erectile dysfunction (ED) whereas its relationship with male infertility is more conflicting. The term metabolically healthy obesity (HO) has been used to describe an obese phenotype that does not have the burden of any metabolic disorder. The aim of the present study is to analyse the contribution of HO in the pathogenesis of ED and male infertility and to verify the value of HO in predicting major adverse cardiovascular events (MACE).<...

Background: Low testosterone (T) is frequent in men with chronical illnesses. The clinical features of T deficiency (TD) overlap with those of chronic diseases. The aim of this study is to evaluate the relative contribution of chronic disease score (CDS) and low T to the presence of TD symptoms.Methods: A consecutive series of 3862 men (aged 52.1±13.1 years) consulting for sexual dysfunction was studied. Several clinical and biochemical parameters w...

Introduction: Tadalafil 5 mg once daily (T5od) has been recently approved by the Food and Drug Administration for the treatment of lower urinary tract symptoms (LUTS), along with erectile dysfunction (ED). Recent pooled data analyses demonstrated that T5od–International Prostate Symptom Score related improvements were significant regardless of confounders. In addition, PDE5 inhibitors exert a positive effect on ejaculatory latency. We assessed the clinical outcome of 30 d...

Introduction: Secondary hypogonadism (sHG) is the most common form of hypogonadism. sHG can arise from any dysregulation of hypothalamic-pituitary (HP) axis due to functional or organic disorders. HP organic disorders are often diagnosed using pituitary magnetic resonance imaging (MRI). However, MRI is an expensive and not widespread exam and it cannot be routinely offered to all sHG patient. The Endocrine Society guidelines suggest MRI scan in sHG men with total testosterone ...

Background: Prevalence of hypogonadism is high (30%) in men with HIV. In these patients T treatment (TT) is currently used mainly to counteract wasting syndrome and/or HIV-related lipodystrophy, irrespective of patients’ serum T. However, its effect and safety in HIV-infected men is still not completely known.Aim: To investigate both beneficial and adverse effects related to TT in HIV-infected men using a meta-analytic approach.<p class="abstext...

Introduction: In the last few years the view that subclinical endocrine disorders represent milder forms of the clinically overt disease has emerged. Accordingly, it has been proposed that compensated hypogonadism represents a genuine clinical subgroup of individuals with late onset hypogonadism (LOH). The aim of the present study is to investigate the association of compensated hypogonadism with clinical and psychological characteristics of male subjects complaining for sexua...

Introduction: The role of testosterone in cardiovascular (CV) health of men is controversial. Several data suggest that hypogonadism is associated with CV mortality but not morbidity. However, recent evidence shows that hypogonadal subjects treated with testosterone replacement therapy have a higher incidence of major adverse CV events (MACE). The aim of this study is to analyse whether the gonadal status might predict MACE incidence according to the previous history of MACE, ...

Introduction: Erectile dysfunction (ED) is considered an early surrogate marker of silent, or even overt, cardiovascular diseases (CVD). However, epidemiological studies take into account only sexual intercourse-related erections. Although autoeroticism is a very common practice, data on masturbation-induced erections as a possible predictor of major adverse cardiovascular events (MACE) are lacking.Aim: To evaluate the clinical correlates of impaired mas...