Endocrine Abstracts

Background: Clinical evaluation of Graves’ orbitopathy (GO) is often insufficient. Frequently it is difficult to decide whether a case of GO is active, or to detect the degree of severity. STIR sequence MRI suppresses signal from fat and thus in the orbits can also detect active inflammation and oedema of extra-ocular muscles (EOMs). The aim of the present study is to examine whether imaging of rectus EOMs with STIR MRI could provide additional information for the activit...

Objectives: i) To measure olfactory bulbs and sulci using dedicated magnetic resonance imaging (MRI) sequences in idiopathic isolated hypogonadotropic hypogonadism (IHH) patients with a well detailed phenotype characterization. ii) To correlate MRI findings with a clinical smell test.Methods: SUB:Pituitary – Clinical (Generously supported by IPSEN)MRI was performed in 20 patients (all males, aged between 11 and 45 years, mean age of 26) wit...

Objectives: i) To measure olfactory bulbs and sulci using dedicated magnetic resonance imaging (MRI) sequences in idiopathic isolated hypogonadotropic hypogonadism (IHH) patients with a well detailed phenotype characterization and ii) to correlate MRI findings with a clinical smell test.Methods: MRI was performed in 20 patients (all male, aged between 11 and 45 years, mean age of 26) with IHH and olfactory dysfunction was assessed using the smell identif...

Local regulation of T3 action in bone and cartilage is a novel mechanism underlying the pathogenesis of osteoarthritis (OA). Accelerated chondrocyte differentiation is a hallmark of OA and T3 regulates this process. The type 1 and 2 deiodinases (D1, D2) convert the pro-hormone T4 to the active hormone T3 whilst D3 inactivates both T3 and T4. D1 contributes to circulating T3 levels and local T3</s...

Context: Kallmann syndrome (KS) is a developmental disease associating congenital hypogonadotropic hypogonadism (CHH) and sense of smell impairment owing to olfactory structures (OS) aplasia/hypoplasia. Although rhinencephalic MRI allows to detect specific KS OS abnormalities useful to discriminate KS from normosmic CHH (nCHH), this technique is not efficient enough to study anterior skull bone structures.Objectives: To search for specific anterior skull...

In July 2010, a 69-year-old woman presented because of a CT proven 5th lumbar vertebral metastasis of thyroid carcinoma and in August she underwent a total thyroidectomy and central node dissection. Histopathology revealed a moderately differentiated Hürthle cell carcinoma which was according to TNM classification pT3N1M1 tumor. Thereafter, a right hemylaminectomy of L5 and metastasectomy was performed in order to decompress the L5 and S1 spinal nerves. The histopathology...

Background: Serotonergic signalling has been implicated in numerous hypothalamic functions including circadian rhythmicity, feeding and the modulation of neuroendocrine systems. In spite of the importance of these functions, the neuroanatomy of the serotonergic system in the human hypothalamus is still unknown.Aim and methods: To increase insight in hypothalamic serotonin signalling in humans, we investigated the distribution of serotonin transporters (S...

Objective: To examine association between diabetes properties (type, duration, treatment regiment etc.) and risk of any fracture in diabetic population.Methods: We analyzed local trauma clinic data for 3 sequential years from 2662 diabetic persons who were entered The National Register of diabetes mellitus patients (133 subjects with type 1 diabetes mellitus (T1DM) and 1995 ones with T2DM).Results: Fracture risk was higher in T1DM ...

Recent reports confirmed increased SSTR expression in the thyroid in some cases of Graves’ disease and hot nodules. It is still not known, whether SSTRs can frequently be found in other thyroid pathologies or normal thyroid glands. Therefore, we performed a systematic analysis of Ga-68-Dotatoc PET Scans for their thyroid image.Eighty-three consecutive patients undergoing Ga-68-Dotatoc PET were analysed for their relative thyroid uptake by ROI techni...

Background: Hashimoto’s encephalopathy is a rare steroid-responsive condition associated with high antithyroid antibody titres. We report a case of autoimmune thyroiditis presenting with status epileptics.Case: A 36-year-old non-epileptic Caucasian lady presented as an emergency with uncontrolled generalised seizures requiring sedation, short-term ventilation and maintenance sodium valproate therapy. Further enquiry revealed a 3–4 week history ...