Searchable abstracts of presentations at key conferences in endocrinology

ea0037s28.2 | Hormones and immunity in pregnancy | ECE2015

Sex hormones and B cells in pregnancy

Jensen Federico

Mammalian pregnancy is characterized by tremendous changes and adaptations in the endocrine as well as in the immune system. Early in pregnancy, levels of female sex hormones, progesterone (P4) and estradiol (E2) produced by the corpora lutea (CL) significantly rise, promoting huge modifications of the uterine epithelium ensuring embryo implantation. Once the embryo is implanted, trophoblast cells produce and release increasing levels of human chorionic g...

ea0102103 | Thyroid | EYES2024

Thyroid hormones regulate the transcriptome of infiltrating microglia

Linnossuo Veli , Salas-Lucia Federico

Thyroid hormones (TH) stimulate the growth of microglia cellular processes, which are reduced in hypothyroid and increased in hyperthyroid pups. However, how TH triggers its effects on these cells remains unexplored. Using confocal immunofluorescence, we have found that in the brains of postnatal day (P)5 mice, infiltrating microglia with a motile ameboid phenotype (lectin tomato and iba1 positive) exhibit strong staining of the inactivating deiodinase type 3 (D3). However, wh...

ea0081oc3.3 | Oral Communications 3: Thyroid 1 | ECE2022

Adata-driven approach reveals emerging risk factors for recurrent and persistent differentiated thyroid cancer

Gentili Michele , Grani Giorgio , Siciliano Federico

Background: The appropriate risk stratification of patients with differentiated thyroid cancer (DTC) is crucial because most cases have an indolent behavior and need a conservative approach. One of the most widely used tools is included in the American Thyroid Association (ATA) Guidelines, based on heterogeneous literature data derived by different populations, settings, and timeframes. Recent research focused on the inclusion of other features or questioned the clinical relev...

ea0016p316 | Endocrine tumours | ECE2008

Effects of pasireotide on bronchial carcinoids in primary culture

Zatelli Maria Chiara , Tagliati Federico , Luchin Andrea , Bondanelli Marta , Rea Federico , degli Uberti Ettore

Bronchopulmonary endocrine tumors represent 25–30% of lung neoplasms. Surgery provides good survival for differentiated tumors (typical and atypical carcinoids), but is not useful for aggressive poorly differentiated forms. Somatostatin (SRIF) analogs can be used as medical therapy, prolonging patient survival. However, the compounds employed so far did not display antiproliferative effects. Recently, a new stable SRIF analog, pasireotide (SOM230), which activates SSTR1, ...

ea0049gp245 | Thyroid Cancer & Thyroid Case Reports | ECE2017

A statistical, in silico model predicts polygenic thyroid cancer risk

Casarini Livio , Marino Marco , Nuzzo Federico , Simoni Manuela , Brigante Giulia

Introduction: The detection of a unique genetic marker is not possible for multifactorial diseases, such as thyroid cancer (TC), where the pathological phenotype is given by the contribution of multiple genes, environmental factors and lifestyle. We found a mathematical model for inferring the risk of thyroid cancer, an example of multifactorial disease.Methods: Genetic data represented by 184 SNPs associated to thyroid tumors were used for Bayesian clus...

ea0041ep319 | Clinical case reports - Pituitary/Adrenal | ECE2016

Hair loss after transesphenoidal surgery in patient with cured acromegaly

Sierra Milagros , Calatayud Maria , Allo Gonzalo , Hawkins Federico

Hair loss after surgical treatment for acromegaly has been rarely described. We report a case of a patient with acromegaly that presented with hair loss after surgical treatment.We describe a case of a 73-year female that was diagnosed with acromegaly. Transesphenoidal surgery was performed with complete tumour resection and no immediate complications. Postoperative IGF -1, GH and OGTT for GH were measured at 12 weeks confirming biochemical remission. Th...

ea0032p275 | Clinical case reports - Thyroid / Others | ECE2013

Submandibular ectopic thyroid gland

Dominguez-Lopez Marta , Gonzalez-Molero Inmaculada , Ruiz MSol , Soriguer Federico

Introduction: Ectopic thyroid glands are generally a rare entity appearing mostly in the cervical midline (90% of the cases) and even more rarely in other anatomical sites (10%).Clinical report: We present the case of an ectopic submandibular thyroid gland. A 31-year-old woman was referred to our department with a history of left submandibular swelling.A scintigraphy was performed, which showed an accumulation of activity in the ri...

ea0032p1004 | Thyroid (non-cancer) | ECE2013

Overweight/obese women with primary acquired hypothyroidism in appropriate levothyroxine replacement therapy are characterized by impaired whole body energy metabolism

Martucci Federico , Manzoni Giuseppina , Lattuada Guido , Perseghin Gianluca

Introduction: Appropriately titrated levothyroxine (L-T4) replacement therapy may not be able to fully correct the entire set of metabolic defects afflicting individuals with primary hypothyroidism. Based on this hypothesis, the present study was undertaken to establish whether these patients have impaired whole body energy metabolism.Methods: We recruited 30 hypothyroid women with duration of the disease >2 years, BMI >...

ea0022p301 | Diabetes | ECE2010

Hypovitaminosis D and microvascular complications in diabetic patients

Garcia Elena , Martinez Guillermo , Sanchez Raquel , Hawkins Federico

Background: High prevalence of hypovitaminosis D in diabetic patients has been reported and has been associated with microvascular complications and insulin treatment in type 2 diabetic patients.Methods: Observational study in 92 inhospital patients with different types of diabetes. We analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with diabetes.Results: Of 36...

ea0020p540 | Growth Factors | ECE2009

IGFBP3 and IGFBP2 negatively and positively modulate IGFs autocrine effect in lung cancer cell lines

Arvigo Marica , Gatto Federico , Ameri Pietro , Ferone Diego , Minuto Francesco

Insulin-like growth factors (IGFs) play an important role in the pathogenesis of several neoplasias and the IGF-binding proteins (IGFBPs) may have a role as autocrine/paracrine factors in regulating the local actions of the IGFs. In the present study we investigated IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 production in cultured media from three human lung cancer cell lines (Calu-3, Calu-6, A549) and in human neoplastic and normal lung tissue samples obtained at surgery fr...