Endocrine Abstracts

Background: The combination of various endocrine tumours is presented both as hereditary syndromes and sporadic forms. Medullary thyroid cancer and prolactinoma are neuroendocrine tumours, the presence of these two pathologies simultaneously has not been previously described in the literature.Objective: To present a clinical case of a patient with giant prolactinoma and medullary thyroid cancer.Materials and Methods: To describe th...

Background: One of the complications of hypothyroidism is the disorder of the neuromuscular system. Myopathic changes often accompany hypothyroidism and are observed in 30-80% of patients. A distinctive feature of hypothyroid myopathies is the reversibility of clinical manifestations and significant improvement of well-being after levothyroxine compensation of the disease. However, the absence of a vivid clinical picture of hypothyroidism, combined with its rare occurrence, co...

Introduction: Crooke’s cell adenomas (CCA) are a rare type of pituitary neoplasm, associated with Cushing’s disease. They are characterised by accumulation of perinuclear cytokeratin filaments, appearing distinctly hyaline in hematoxylin and eosin (HE) staining (Crooke’s hyaline change). Due to their rarity, the management and treatment remain a challenge.Clinical case: A 33-year-old male patient, presented sudden visual impairment, no sig...

Targeted therapy based on tyrosine kinase inhibitors (TKIs) constitutes a new treatment modality in thyroid cancer (TC). Their efficacy in prolongation of progression free survival in comparison to placebo has been documented in phase III studies. However, a problem of their tolerability has recently risen as numerous side effects influencing the quality of life may potentially limit their clinical use. Therefore, we decided to carry out a retrospective analysis of the frequen...

Plasticisers such as bisphenol A (BPA), bisphenol S (BPS), and phthalates (PAE) are commonly used in daily life in electronic equipment, cans, plastic food containers, and bottles. These substances can interact with oestrogen receptors as well as androgen receptors and therefore they are called endocrine disrupting chemicals (EDC). The aim of this study was to evaluate serum concentrations of BPA, BPS, and selected PAE in healthy women and women with polycystic ovary syndrome ...

Introduction: Follicular adenomas (FTA) and carcinomas (FTC) are thyroid tumours that are indistinguishable in the fine needle aspiration biopsy (FNAB). In our previous research we concentrated on post-operative material and developed the classifier, which discriminates the FTC and FTA, based on formalin-fixed paraffin-embedded (FFPE) material. The classifier was based on expression of five genes and gave the promising sensitivity of 71% and specificity of 72%. The aim of the ...

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, that lead to infertility, type 2 diabetes and coronary heart disease.Bisphenol A (BPA) is one of the most abundant chemicals produced worldwide and is used as a plasticizer in daily life. Nowadays it is also well know that it can interact with estrogen receptors, androgen receptors and peroxisome proliferator-activated receptors γ (PPARγ). Therefore...

Objective: Polycystic ovary syndrome (PCOS) is more prevalent among women with type 1 diabetes (T1DM) than in general population. Autoimmune thyroiditis (AIT) is the most common autoimmunological disease in young women in reproductive age, especially in T1DM. Data in literature indicate the possible role of thyroid autoimmunity in PCOS pathogenesis. It has been suggested that positive concentration of thyroid peroxidase antibodies (TPOAbs) is associated with increased prevalen...

Background: PRRT is an effective treatment option (especially for controlling disease progression)for disseminated neuroendocrine tumors (NETs), with good expression of the somatostatin receptors. Despite significant progress in NET personalized management, searching for novel predictive and prognostic factors of response to PRRT is crucial for more effective follow-up, better treatment choices leading to more favorable final outcome. Some recent studies indicate that the resp...

Introduction: Diagnostic delay remains significant among the patients with acromegaly, even though the disease awareness has improved over the years.Aim: The aim was to investigate the diagnostic delay and symptoms present at diagnosis of acromegaly among the newly-diagnosed patients.Material and methods: 72 consecutive patients diagnosed with acromegaly between 01.2014 and 12.2021 were evaluated. Division into groups based on: gen...