Endocrine Abstracts

We would like to present a case of primary hyperparathyroidism presumably present with clinically large cystic parathyroid adenoma with multiple destructive skeletal lesions, which is of course referred to bone metastases.Case: A 58-year-old male patient was admitted to the orthopedy polyclinic with left leg pain and on the MR imaging performed here, multiple lytic lesions compatible with metastasis to the tibia and fibula were detected. He was directed ...

Purpose: GDM is defined as any degree of carbonhydrate intolerance that is first diagnosed during pregnancy. Patients diagnosed with GDM are expected to have complications such as Type II DM, obesity, hypertension in the long term. Prevalence of GDM diagnosis during pregrancy changes between 2 and 10%. Our purpose is to revaluate the OGTT of the patients diagnosed with GDM, with regard to their postpartum Type II DM progress.Materials and methods: 450 pr...

Aim: The lipid accumulation product (LAP) index which is associated with abnormal glucose regulation can be easily calculated. Women with polycystic ovary syndrome have more than one risk factor for the development of cardiovascular diseases such as glucose intolerance, insulin resistance and abdominal lipoidosis. In this study, we intend the evaluation of LAP index in women with PCOS.Method: This study included 35 women patients with PCOS (mean age 22.4...

Aim: In a previous study, we demonstrated elevated mean platelet volume in isolated hypogonadotrophic hypogonadism (IHH) is associated with high cardiovascular risk. Monocyte count/HDL-cholesterol ratio (MHR) is a new inflammatory marker showing cardiovascular risk. The purpose of this study is to evaluate (MHR) in men with hypogonadotrophic hypogonadism.Method: This study includes 31 men with isolated hypogonadotrophic hypogonadism without previous trea...

Abdominal surgery and diseases such as endometriosis cause persistent abdominal adhesions leading to pelvic pain, infertility and in severe cases, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent feature. Lysyl oxidase (LOX) is a key enzyme required for crosslinking and deposition of insoluble collagen.10–12 weeks old female C57Bl/6 mice (3–10 mice per gro...

Silent pituitary adenomas are defined as a group of adenomas that are hormonally inactive and do not show clinical signs and symptoms of excess hormones. Data in the literature indicate that fertility is usually affected in women with silent pituitary adenomas.Aim: To investigate the possible effects of silent pituitary adenomas on pregnancy.Patients and method: Thirty patients followed by silent pituitary adenoma, without hormone ...

Transphobia is expressed as negative attitudes, emotions and actions towards transgender individuals or transsexualism. The aim of this study is to investigate the existence of transphobic approaches towards transgender individuals in physicians in different clinics that play an active role in the gender transition process. It was planned to include physicians from the disciplines of psychiatry, endocrinology, gynecology, urology and plastic surgery. A questionnaire was sent t...

Introduction: Congenital Adrenal Hyperplasia (CAH) results from enzymatic defects caused by autossomal recessive hereditary mutations characterized by deficient cortisol synthesis and, in most cases, increased androgen synthesis. 90–95% of the cases are originated by deficits in 21-hydroxylase and, in about 75% of the cases, there is evidence of mineralocorticoid deficiency.Case report: A 37-year-old patient was referred to an Endocrinology departm...

Introduction: Acromegaly is a chronic disease caused by excess growth hormone (GH) release from an adenoma caused by somatotroph cells of pituitary gland.In acromegaly, it is known that the risk of thyroid and colon cancer is increased 8 and 4 times, respectively, compared to the normal population.Moderate hypercalcemia, due to vitaminD activation, is seen in acromegaly, but overt hypercalcemia, generally secondary to primary hyperparathyroidism, is rare.Combination of acromeg...

Introduction: Radioactive iodine (131I) therapy is a safe and cost-effective choice in Graves’ disease (GD). Usually only one treatment with 131I is sufficient, however, individual characteristics of the disease can lead to its recurrence. The aim of this study is to determinate the risk factors that influence the recurrence of GD after 131I.Materials and methods: Retrospective cohort study in 528 patients with GD who did <sup...