Endocrine Abstracts

Introduction: Osteoporosis is a disease characterized by a decreased bone strength, as a result of increased bone porosity and impaired mineralization. According to the mechanostat theory, loads generated by the muscle mass and muscle strength, stimulate bone reconstruction.Aim of the study: In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclero...

Introduction: Secretory adrenal tumors sensitive to luteinizing hormone (LH) and/or human chorionic gonadotropin (hCG) are well documented in the literature. LH and hCG share a mutual LH/hCG receptor and a comparable physiological role.Objective: The aim of our study was to evaluate the response of adrenal steroids (cortisol, aldosterone and dehydroepiandrosterone sulphate (DHEAS)) to exogenous hCG stimulation in menopausal patients with adrenal incident...

Background: ACTH-Independent Macronodular Adrenal Hyperplasia (AIMAH) is usually manifested as both-sided adrenal incidentalomas with subclinical overproduction of cortisol (<2% of Cushing’s syndrome). The pathogenesis involves genetic factors, expression of adrenal aberrant hormone receptors and paracrine adrenal corticotropin (ACTH) secretion. Treatment is usually bilateral adrenalectomy, but in some cases also unilateral adrenalectomy or pharmacologic therapy can b...

Premature ovarian insufficiency (POI) is characterized by cessation of ovarian function before the age of 40. Variable clinical presentation often postpones the diagnosis. The aim of our study was to assess whether there is a typical menstrual cycles pattern in patients with POI. We have evaluated 101 women, age 36.7±5.78 y. FSH=78.81±37.43 IU/l, E2<50 pg/dl, with confirmed POI referred to our Clinic between 2014 and 2018. Menstrual cycles characteristics were de...

Introduction: It is presumed that hiccups are a vestigial reflex in mammals. They are rather common in healthy subjects. Persistent hiccups (lasting >48 h) are a serious clinical sign, and documented in a number of debilitating conditions. According to the available literature persistent hiccups in Addisonian crisis have been previously documented in only two patients.Case report: In July 2018, a 39 year old man checked into the ER complaining of nau...

Traumatic thoracic injuries in children and adolescents are rare, but could be connected with others traumas, often with traumatic brain injury (TBI). Based on data in the current literature, approximately 15–20% of TBI patients develop chronic hypopituitarism. Growth hormone (GH) and ACTH deficiency are the most common, followed by gonadotropins and thyroid-stimulating hormone. The greatest challenge associated with endocrine complications in individuals with polytrauma ...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

Objective: The management of pituitary tumors causing Cushing’s Disease are a multidisciplinary challenge to clinicians with neurosurgery as a first line treatment followed by the radiotherapy and pharmacotherapy including chemiotherapy.Such tumors are difficult to treat with high rate of recurrence. To date only 25 patients with Cushing Disease treated with the new alkylating agent temozolamide (TMZ) have been reported.Materials and methods: Sixty-...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant condition characterized by varying combinations of endocrine tumors and commonly accompanying hyperplasia within the parathyroid gland, anterior pituitary and gastrointestinal tract. Heterozygous germline mutation of the tumor suppressor gene MEN1 is the most common cause of the disease. Molecular genetic testing of menin gene, in which mutation is known to cause MEN1 syndrome, detects pathogenic...