Endocrine Abstracts

BackgroundPituitary adenomas are general benign tumors. However, gross invasion at time of operation is observed in up to 35% of pituitary adenomas. The new WHO classification describes pituitary tumor subtypes along with histological markers, such as Ki67 > 3%, that may suggest a potential for aggressive clinical behavior. The expression of EGFR in tumor microenvironment of pituitary adenomas ant its correlation with tumor behavior have been poorly ...

Background: Pituitary adenomas(PAs) comprise 10%–25% of all intracranial tumors, the majority of them being benign. But 35% of all PAs are considered invasive, having a higher recurrence rate than benign ones.Objectives: We analyzed the expression of different angiogenic growth factors and their receptors in PAs and identified correlations with the hormone profile that could explain their behavior and prognosis.Methods: Our st...

Introduction: Hyperthyroidism and thyrotoxicosis can have multiple etiologies, varying from the most frequent described in clinical practice (Graves disease, toxic nodular goiter, thyroiditis) to very rare causes such as anaplastic thyroid cancer, thyroid lymphoma, amyloidosis or even secondary malignancy of the thyroid gland.Case report: A 53 year old man presented to our department for progressive goiter enlargement in the last two months which was acc...

Introduction: Acromegaly is characterized by elevated levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), most often due to a pituitary tumor. Persistent high levels of these hormones lead to a constellation of signs and symptoms and systemic complications associated with increased mortality. A potential association between acromegaly and cancer has been hypothesized regarding colorectal, thyroid, and prostate cancers, but there are few or no descriptions f...

Introduction: The development of pituitary gland is orchestrated by genetic signals, transcription factors and signaling molecules with a crucial role in cell proliferation and differentiation. Anterior pituitary gland is formed by both granular (secretory) and agranular cells represented mainly by follicular-stellate cells. It is known that these cells form a supporting network around secretory cells and produce many kind of growth factors, but their major function remains un...

Introduction: Functional amenorhea can appear due to chemical, emotional of physical chronic stress. It is particular pathology with special issues regagring long therm body sustaiment after the occurence of menses cessation. Material comprise 39 young women, with ages between 17 and 34, (mean age of 24.55±6.09 years), 11 adolescents and 28 adult women, with secondary amenorrhea induced by weight loss, there were addressed to our Endocrine Unit, starting January 2014. Inc...

Introduction: Meigs’ syndrome is defined as the presence of a benign ovarian tumour (fibroma), in association with ascites and hydrothorax. The characteristic feature of this condition is the resolution of the effusions once the tumour is surgically removed.Case report: A 63 year-old female patient was admitted to the Surgery Clinic with metroragia, abdominal distention, and a recent history of minor breath shortness. Pulmonary clinical examination ...

Background: The role of EGFR, HER2, PDGF-A and the axis PDGF-B/ PDGFR-β in the pathogenesis of pituitary adenomas and their correlation with the tumoral immunoprofile are poorly understood.Materials and methods: The study included 92 cases. We used morphological stains, immunohistochemistry and molecular methods to characterize the tumors.Results: 33.33% of adenomas showed a positive immunohistochemical reaction for HER2- with...

Introduction: Adrenal myelolipoma is a rare benign tumour composed of mature adipose tissue and haematopoietic elements developed within the adrenal gland, usually unilateral, asymptomatic, and non-functional. Their real incidence is unknown.Case report: A 56 year-old female was admitted to our surgery department for abdominal distension and the presence of a large palpable tumour in the right abdomen discovered during an abdominal ultrasonographic check...

Introduction: Chronic hypergastrinemia is no longer an uncommon phenomenon. Zollinger-Ellison syndrome [ZES], chronic atrophic gastritis [CAG] type A, proton pump inhibitors [PPI] therapy, or Helicobacter pylori-induced CAG type B are causes of hypergastrinemia. Serum gastrin levels >1000 pg/ml (> 0 times the upper limit of normal) and PH gastric below 2 is the diagnostic of ZES, but two -thirds of ZES patients have serum gastrin levels below 1000 pg/ml. We present the...