Endocrine Abstracts

Objective: Oxidative stress has been implicated in the pathogenesis of several immune-mediated disorders, including autoimmune thyroid disease. Aim of our study was to investigate the relationship between dietary habit and redox homeostasis, in relationship with thyroid autoimmunity.Materials and methods: We enrolled 200 healthy subjects (173 F, mean age 35 ± 12). None of them was under any pharmacological treatment. Exclusion criteria: any infectio...

Background: Osteogenesis imperfecta (OI) is a few frequent disease with abnormal synthesis of type 1 collagen. That affects skeletal but also extra-skeletal tissues. Aortic root (AR) dilatation and valvular dysfunction have been described. Other studies, to estimate the size of the AR, index it by the body surface area (BSA), however, although these patients are shorter their internal organs have a relatively normal growth, so we could find overestimated AR values. Therefore, ...

Introduction: Diabetes mellitus is associated with an increased risk of osteoporotic fractures, which leads to an increased risk of disability and frailty.Aims: To assess the prevalence of frailty in type 2 diabetes and to analyze the relationship with bone mineral density (BMD) and Trabecular Bone Score (TBS), fracture risk and prevalent fractures.Methods: We carried out a cross-sectional study of 75 diabetic patients (65±7 y...

Introduction: Central diabetes insipidus is a disorder characterized by polyuria and polydipsia due to vasopressin deficiency caused by a lesion at the hypothalamo-hypophyseal axis. Frequently, central diabetes insipidus is wrongly considered idiopathic if not associated with other neurological signs and symptoms. Herein we present the report of a case that illustrates the difficulties in the diagnosis of this condition.Case report: A 17 year-old male wa...

Introduction/ objectives: Turner syndrome (TS) comprises a group of sex chromosomal abnormalities of heterogeneous clinical presentation. During the infant period, the pediatric endocrinologist coordinates their follow-up and it is important to ensure its continuation during the adult stage. The objective of this study is to know the current clinical situation, occupational, educational, social and medical monitoring of patients affected TS in Tenerife.M...

Introduction: Non-islet cell tumor induced hypoglycemia (NICTH) is a paraneoplastic phenomenon involving many types of tumors. It is associated with the secretion of incompletely processed precursors of IGF-2 resulting in a persistent insulin-like activity and hypoglycemia. Most commonly, IGF-2–linked hypoglycemia has been observed in patients with solid mesenchymal or epithelial tumors. Typically, elevated IGF-2 levels are associated with suppressed plasma levels of insu...

IntroductionThe most cost-effective, minimally invasive and accurate tool to discriminate benign from malignant thyroid nodules is a fine-needle aspiration biopsy (FNAB). However, 2%–24% of FNABs provide non-diagnostic results, which are a clinical challenge, particularly when this result is recurrent.AimTo determine the predictive factors for recurrent non-diagnostic FNAB in thyroid nodules.<p class...

IntroductionRecent published studies suggest that the anatomical location of the thyroid nodule may be associated with different risks of malignancy. However, the results are still sparce and little consensual.AimTo evaluate the frequency of nodules on different locations of the thyroid gland and to determine whether their location correlates with different malignancy risks.Methods<...

Introduction: Obesity is a known risk factor for hypovitaminosis D and although several studies point out that higher adherence to the Mediterranean Diet (Diet-Med) is associated with higher dietary vitamin D intake, there are very limited data on the influence of Diet-Med on serum 25-Hydroxy Vitamin D (25OHD) levels. Our aim was to evaluate the relationship between adherence to Diet-Med and vitamin D status in obese patients.Material and Methods: Retros...

Introduction: DM 1 is proposed as a condition of accelerated muscle aging and mitochondrial dysfunction as a common link regulating muscle deterioration in aging and DM 1. Loss of muscle mass is associated with insulin resistance, metabolic syndrome and cardiovascular complications.Objectives: To analyze body composition and metabolic variables related to insulin resistance in overweight/obese patients with DM1.Material and MethodsObservational, cross-se...