Endocrine Abstracts

Hypothesis: High doses of vitamin D (VitD) improves dermal microcirculation (MC) in diabetic patients with type 2 diabetes mellitus (T2DM) and diabetic neuropathy (DN).Purpose: To study the effect of different VD doses on skin MC values in T2DM patients and DN.Materials and methods: Sixty-two non-smoking T2DM patients with DN were randomized into two groups: Group 1 received 5000 IU (G1) and Group 2 received 40000 IU (G2) of cholec...

Background: DiGeorge syndrome (DGS) is the rare genetic disorder caused by a 22q11.2 chromosome microdeletion. The main clinical features are associated with defective development of the pharyngeal pouch system and usually include congenital heart disease, hypoplasia of thymus resulting in immune deficiency and hypoparathyroidism. Also DGS patient has characteristic long face with narrow palpebral fissures, broad nasal bridge, micrognathia and small mouth, small dysmorphic ear...

Background: Approximately 25% of patients with parathyroid carcinoma (PC) have metastases; the most frequent sites include cervical lymph nodes (30%) and lungs (40%). Less common are liver, bones and brain. Surgical resection of local or distant metastases (if possible) provides the best control of hypercalcemia and enhances long-term survival.Case description: A 70-year old patient was admitted to hospital with a primary hyperparathyroidism (PH). He did...

Objective: To establish possible associations of the polymorphism of the insulin receptor substrate−1 (IRS-1) gene with the severity of various components of metabolic syndrome in patients with arterial hypertension (AH). We examined 187 patients with AH aged 45–55 years (with history of hypertension less than 5 years, unsystematic administration of antihypertensive drugs and/or failure to achieve target blood pressure (BP) levels when prescribing drug therapy). The...

Introduction: False memory, that is, remembering events, prohibitions and recommendations that did not happen. This phenomenon has long been known in forensics as it seems to be much more recognized in everyday life. This also applies to patients who could significantly interfere with communication with the doctor and education opportunities. In the face of surprisingly few papers on this subject regarding diabetes, we would like to present our observation.<p class="abstex...

Infrared Thermography (IT) is a non-invasive method and complementary to other diagnostic techniques to identify inhomogeneity of the thermal emission of the skin. We used IT (InfRec R500, Nippon Avionics Co.; 640×480 pixel, spatial resolution 0,87 mrad, sensitivity 0.03°C at 30°C, accuracy ±1°C) to assess the variations of skin temperature of the neck region: higher mean temperature, greater thyroid function. Primary outcome of this study was to compa...

Introduction: Myelolipomas account for 5–15% of all resected adrenal masses and are considered as benign lesions consisting of fat and myeloid tissue. Their pathogenesis is mostly unknown, though altered mesenchymal stem cell function or a sustained respond to increased ACTH stimulation are discussed. Even though these findings are partly inconclusive, an increased incidence of myelolipoma in patients with congenital adrenal hyperplasia (CAH) has been reported, which may ...

Objective(s): Last data showed advantages of TBS assessment of bone quality over BMD in patients with type 2 diabetes (T2D). We perform DXA in patients with T2D and calculated 10-year probability of fracture using FRAX® tool.Material and methods: A total of 252 (172 females) T2D patients aged 36 to 86 y.o (mean 61.0±8.8) were examined. BMD was performed in 124 patients (110 females) using DXA (Lunar Prodigy, USA). BMD adjusted for TB...

Background and aims: Type 1 diabetes mellitus (T1DM) requires daily self-management to mimic endocrine function, using numerical skills such as carbohydrate counting and interpreting nutritional information. Healthcare professionals (HCPs) rely on effective communication to relay information to people with T1DM to enable good self-care. Curricula for diabetes self-management education (DSME) courses require high-school level numerical skills. Eighty percent of adults in the Un...

Background: Network analysis of species abundance across different individuals suggested that the overall structure of the human gut microbiota in each individual conforms to discrete and distinct patterns defined by interactions within community members. This hypothesis was investigated using a dataset of metagenomic sequences from American, European and Japanese individuals. Multidimensional cluster analysis and principal component analysis revealed that all individual sampl...