Searchable abstracts of presentations at key conferences in endocrinology

ea0056p169 | Bone ' Osteoporosis | ECE2018

Effect of surgery vs observation: 6-Year skeletal outcomes in primary hyperparathyroidism

Ramos Laura , Piedra Maria , Munoz Pedro , Vazquez Luis , Amado Jose Antonio

Background and aims: Primary hyperparathyroidism (PHPT) often presents without classical symptoms such as overt skeletal disease or nephrolithiasis. Treatment strategies have been widely discussed. The objective of our research was to study the effect of parathyroidectomy (PTX) compared to observation (OBS) on skeletal outcomes such as bone mineral density (BMD).Subjects and methods: A retrospective observational study was conducted between 1991 and 2014...

ea0056p213 | Calcium & Vitamin D metabolism | ECE2018

Epidemiology of primary hyperparathyroidism in Santander, Spain

Ramos Laura , Munoz Pedro , Piedra Maria , Vazquez Luis , Amado Jose Antonio

Background and aims: Primary hyperparathyroidism (PHPT) is a common endocrine disorder with different epidemiological patterns among countries. The incidence of PHPT is unknown in Spain. The aim of our study is to assess the prevalence and incidence of diagnosed PHPT in adults between 1970 and 2014 in Santander, a population of 290.000 inhabitants, located in the north of Spain.Subjects and methods: All patients diagnosed with primary hyperparathyroidism...

ea0056p313 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Metabolic syndrome and triglyceride-rich lipoproteins

Paredes Silvia , Fonseca Liliana , Carlos Oliveira Jose , Ramos Helena , Palma Isabel

Introduction: Hypertriglyceridemia, a cardinal feature of metabolic syndrome (MS), is associated with cardiovascular disease and abnormal metabolism of apolipoproteins which may form the basis for this relationship. The aim of this study is to evaluate triglyceride-rich lipoproteins profile in MS patients.Material and methods: A retrospective study was performed, including patients evaluated in a tertiary hospital. Patients with thyroid dysfunction, neop...

ea0056p316 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Identifying metabolic unhealthy obesity using the product of triglycerides and glucose

Fonseca Liliana , Paredes Silvia , Carlos Olivera Jose , Ramos Helena , Palma Isabel

Introduction: There are significant physiologically and clinically differences in profiles between metabolic healthy and metabolic unhealthy obese individuals. Several markers are on study in order to better characterize the metabolic profile of metabolic unhealthy obese individuals. The aim of this work was to determine whether the triglycerides/glucose (TyG) index may be a valuable marker for identifying metabolically unhealthy obesity.Methodology: Met...

ea0056p627 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Cross-hormone treatment: review of cardiovascular risk factors and bone mineral density in 25 transsexual subjects followed in a tertiary hospital

Azkutia Ane , Herraiz Lorea , Jimenez Ines , Barrio Elvira , Ramos Elvira , Cuesta Martin , Diaz Angel

Introduction and objectives: Transsexuality refers to discrepancy between the assigned sex/gender at birth and the one that the subject identifies with. The use of the cross hormone treatment as sex/gender change method implies the necessity of monitorize the hormone levels and potential treatment risks. Our study tries to evaluate the relationship between the hormone changes and the changes in the cardiovascular risk factors and the bone mineral density.<p class="abstext"...

ea0002p16 | Clinical case reports | SFE2001

MASSIVE CHILDHOOD OBESITY IN A PATIENT WITH KLYNEFELTER KARYOTYPE AND PRADDER-WILLY PHENOTYPE

Mendes P , Monteiro L , Cardoso M , Silva C , Santos M , Cunha C , Monteiro T , Ramos M

We report an 18-year-old boy referred to our outpatient clinic at 8 years and 11 months of age with a history of early-onset childhood hiperphagia, infantile central hipotonia and lethargy, mild mental retardation and emotional instability. His height was 125 cm, height SDS = -1 (target height = 169,5 cm, SDS = -0,78) and he weighted 40 Kg (BMI = 25,6;WFH =164%). He had small hands and feet, fat face with prominent forehead, bitemporal narrowing, triangular upper lip, microgna...

ea0002p79 | Reproduction | SFE2001

IMPROVEMENT OF MALE HYPOGONADISM IN SEVERE OBESITY DURING WEIGHT LOSS AFTER BARIATRIC SURGERY

Monteiro M , Cardoso H , Vargas G , Mendes P , Sergio A , Santos M , Santos C , Ramos H

Objectives: To evaluate changes in gonadotrophins, total (TT) and free (FT) testosterone, SHBG, insulin and c-peptide levels during weight lost after bariatric surgery.Material and methods: Seven (n=7) patients submitted to bariatric surgery for treatment of severe obesity were followed-up over time. Before surgery mean age was 32,857 (19-56) years old, mean weight was 170,571 kg (± 37,362) and mean BMI was 58,824 kg per m2(± 14,...

ea0037gp.26.04 | Thyroid – hypothyroidism | ECE2015

Nkx2.5 gene mutations are not associated with congenital heart defects in children with thyroid dysgenesis

Ramos Helton Estrela , de Oliveira Cerqueira Taise Lima , Ramos Yane Rocha , Leite Paula , Santos Jailciele , San Martin Daniel , Costa Anabel Goes , Fernandes Vladimir , Strappa Giorgia , de Jesus Mariana Souza , Amorim Tatiana , Ladeia Ana Marice

Context: Several specific transcriptional factors, in view of their important role in thyroid organogenesis and thyroid specific gene expression, would be strong candidate genes for the etiology of TD. The homeobox transcription factor NKX2.5 was thought to be only required for the organogenesis of the heart tube. However, NKX2.5−/− embryos also exhibited a smaller outgrowing thyroid bud. Indeed, several loss ...

ea0056gp258 | Thyroid non cancer - Autoimmune Thyroid disease/pregnancy | ECE2018

Influence of levothyroxine treatment in pregnant women with thyroid antiperoxidase antibodies

Martinez Paula Fernandez , Garcia Rocio Aguado , Galindo David Emilio Barajas , Martinez Tania Ramos , Arnaiz Elena Gonzalez , Arias Sara Garcia , Ramos Mirian Alejo , Moreno Ana Hernandez , Pomar Maria Ballesteros , Rodriguez Isidoro Cano

Introduction: Thyroid antiperoxidase antibodies above the cut-off value (ATPO +) may increase the risk of maternal-foetal complications and could modify the treatment criteria. The aim of the study is to consider the impact of levothyroxine administration on maternal-foetal complications in ATPO+ pregnant women with delivery in 2016.Methods: In Leon’s health area (Spain), universal screening for gestational thyroid dysfunction is performed. ATPO + w...

ea0081p92 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Transforming growth factor beta 1: a new factor reducing hepatic sex hormone binding globulin production during liver fibrosis development

Brianso Llort Laura , Fuertes Rioja Lidia , Ramos Perez Lorena , Salcedo Allende Maria Teresa , Hernandez Cristina , Canonge Rafael Simo , Martinez David

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...