Endocrine Abstracts

The total 25-hydroxy-vitamin-D (t-25OHD) level reflects the vitamin-D supply, but it is also influenced by the levels of vitamin-D-binding-proteins (DBP) and albumin. The type of dialysis influences the levels of serum proteins. The ‘free-hormone hypothesis’ states that only the free molecules (f25OHD) can diffuse intracellular. Our aim was to evaluate the total, calculated (c-f25OHD) and direct measured (dm-f25OHD) 25OHD levels in patients with chronic renal disease...

The biological organisms are complex systems regulated by the homeostatic back-end network. In these days the growing environmental loads (from industry, household, etc.) contain chemical exposure eg. halogenated hydrocarbons (monuron: MU (C9H11ClN2O), diuron: DU (C9H10Cl2N2O)), which can be endocrine disruptor compounds (EDCs). Synthesis, release of hormones and cell processes of endocrine cells, and...

Background: Adequate vitamin D supply is necessary for bone metabolism and also for the general maintenance of health. 25OHD is transported primarily bound to vitamin-D binding protein (DBP), but also to albumin. Lower concentration of plasma proteins may cause difficulties in immunoanalytics. Our aim was to investigate the protein dependence of the two most often used 25OHD immuno- (CLIA) and protein binding- (ECLPBA) assays.Methods: levels were measure...

Introduction: In vitro adipogenesis is a two-step developmental process in which an undifferentiated mesenchymal cell differentiates into a preadipocyte, which then undergoes a secondary differentiation step to become a lipid-filled adipocyte. The triglyceride accumulation is influenced by various endogenous and exogenous factors.Methods: In an attempt to understand the antipsychotics effects on lipid accumulation duri...

Objective: Our aim was to present a case of paraneoplastic NMDA-R antibody-mediated limbic encephalitis in a woman with OT thereby providing information facilitating diagnosis of OT in women, who present with symptoms of paraneoplastic limbic encephalitis (LE) for obstetricians and gynaecologists with appropriate.Case: We report the case of a 25-year-old women, who developed NMDA-R-antibody mediated autoimmune encephalitis and who displayed confusion, di...

Endocrine disruptor compounds (EDCs) may cause disorders and alter the normal hormone synthesis and/or release.Aim was to investigate the effects of EDCs on normal hypophysis regulation; particularly the arginine–vasopressine (AVP) activated ACTH release from adenohypophysis cells and the monoamine activated AVP release from neurohypophysis cells.Primary monolayer cell cultures prepared from Wistar rat hypophyses. Separated ad...

Objective: Our aim was to evaluate whether multiple mild head trauma or repetitive heading of long term soccer playing causes growth hormone deficiency.Patients and methods: 28 retired previously professional male soccer players were investigated. Nine of them had sport related head injuries. Mean age: 48.7 years (range 36–70; S.D.±7.4); mean sport duration (professional and senior activity): 27.4 years (S.D.±...

Thyroid cancers represent ~1% of new cancer diagnoses. Thyroid malignancies are divided into papillary carcinomas (80%), follicular carcinomas (10%), medullary carcinomas (5–10%), anaplastic carcinomas (1–2%), and other rare tumours (primary thyroid lymphomas and primary thyroid sarcomas). The main therapeutic options are surgery (mainly total thyreoidectomy), radioiodine treatment, levothyroxine therapy (TSH suppression dose), others (external beam irradiation, chem...

Receptor endocytosis plays an important role in regulating the responsiveness of cells to specific hormones. Phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) has been shown to be critical for many endocytic processes including the internalization of G protein-coupled receptors (GPCRs). We have previously shown that depletion of PtdIns(4, 5) P2 by the chemically induced plasma membrane recruitment of a 5-phosphatase domain prevents the internalizati...

Introduction: Hypophysitis is an inflammatory disease of the pituitary that may mimic tumors. Primary hypophysitis has been classified as lymphocytic (LH), granulomatous (GH), and xanthomatous (XH). It has been recently proposed to be an IgG4-related autoimmune disease (serum IgG4 concentration: 135 mg/dl), proven by tissue IgG4 immunostaining.Case description: A 23-year-old men suffered from typical cluster type headache. Two years after the first sympt...