Searchable abstracts of presentations at key conferences in endocrinology

ea0104p80 | Diabetes & Metabolism | SFEIES24

Monitoring and management of inpatients on systemic glucocorticoids – quality improvement for inpatient care

Stephen Fuller Eoin , Mary O'Shea Kate , Pyeh Kyithar Ma

Background: Blood glucose monitoring for inpatients on systemic glucocorticoids is recommended by The Joint British Diabetes Societies for Inpatient Care, due to increased insulin resistance. Stress dosing of steroids during acute illness is recommended by the Society of Endocrinology in patients taking long-term systemic steroids due to the increased likelihood of suppressed hypothalamo-pituitary-adrenal function.Aims: We aimed to determine whether capi...

ea0037ep64 | Adrenal cortex | ECE2015

Serum brain-derived neurotrophic factor in Cushing's syndrome patients

Santos Alicia , Resmini Eugenia , Barahona Ma Jose , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Marin Ana , Webb Susan M

Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that has been linked to several cardiovascular risk factors and bone status. Stress and corticosteroid exposure can affect BDNF levels, although this has never been studied in Cushing’s syndrome (CS). The aims of this study were to establish if BDNF levels were reduced in CS and to check possible associations to cardiovascular risk factors and bone status.Methods: 52 patients (18 ac...

ea0014p45 | (1) | ECE2007

Progression of diabetic retinopathy in pregestational diabetes mellitus

Guerrero R , Martinez Brocca MA , Pomares MA , Palma S , Gonzalez I , Acosta D , Moreno E , Villamil F

Background: Pregnancy may adversely affect the progression of diabetic retinopathy and can have serious implications for the pregnant women.Aim: To asses the impact of pregnancy on the progression of diabetic retinopathy in women with type 1 and type 2 diabetes mellitus and to identify risk factors for the progression of retinopathy during pregnancy.Methods: 306 diabetic women, 229 (75.4%) with type 1 and 77 (23.9%) with type 2 di...

ea0049ep99 | Adrenal medulla | ECE2017

Role of urinary fractionated metanephrines and catecholaminas in the diagnosis of pheochromocytoma/paraganglioma

Martinez-Triguero Ma Luisa , del Olmo Ma Isabel , del Olmo Rosa Camara , Alba Amparo , Fernandez Francis , Merino Juan Francisco , Laiz Begona

Introduction: Paragangliomas/pheochromocytomas present frequently with vague symptomatology which makes its diagnosis difficult and challenging. Cuantification of fractionated metanephrines and fractionated catecholamines in 24 h urine sample are used for diagnosis. There are situationes that can produce false positive results such as stress, drugs or smoking that must be taken into account.Patients and methods: Retrospective study on the requests made f...

ea0041gp127 | Neuroendocrinology | ECE2016

Hypothalamic GRK2, via GPR54, modulates puberty onset

Avendano Ma Soledad , Ruiz-Pino Francisco , Vazquez Ma Jesus , Velasco Inmaculada , Heras Violeta , Torres Encarni , Manuel Castellano Juan , Roa Juan , Pinilla Leonor , Tena-Sempere Manuel

The G protein-coupled receptor (GPCR) kinase 2, GRK2, is a ubiquitous serine/threonine protein kinase that is able to phosphorylate and desensitize the active form of several GPCR. Compelling, as yet limited, evidence from in vitro studies have suggested a potential role of GRK2 in mediating desensitization of Gpr54, the canonical receptor for kisspeptins that is abundantly expressed in GnRH neurons. Yet, although kisspeptins have been universally recognized as essent...

ea0035p137 | Calcium and Vitamin D metabolism | ECE2014

Effects of nutritional intervention program on vitamin D serum levels in adolecents

Pastor M Mar Campos , Pardo Ma Dolores Serrano , Soto Ma Luisa Fernandez , de Dios Luna del Castillo Juan , Gomez-Villalba Fernando Escobar , Escobar-Jimenez Fernando

Introduction: Vitamin D deficiency and insufficiency is highly prevalent even in young people. Vitamin D status has been linked to the BMI and insulin resistance.Aim: Determine 25(OH)D concentrations in adolescents before and after nutritional intervention program (NIP) and its relationship to BMI and metabolic syndrome (MS).Methods: We selected 256 secondary school students (127 males) aged between 12 and 16 years from Granada (Sp...

ea0032p1109 | Thyroid cancer | ECE2013

Predictive value of preablation stimulated thyroglobulin in differentiated thyroid cancer

Sanchez Inmaculada Prior , Moreno Ma Angeles Galvez , Jimenez Carmen Tenorio , Exposito Ma Rosa Alhambra , Ortega Raul Ruiz , Ortega Estefania Moreno , Vallejo Casas Juan Antonio , Lopez Pedro Benito

Background: Previous studies have suggested that serum thyroglobulin (Tg) levels at the time of 131I remnant ablation just after thyroidectomy, could be a prognostic tumor marker in differentiated thyroid cancer (DTC).Objective: The aim of this study was to evaluate if serum preablation Tg in the earliest postoperative period could be useful for predicting persistence or recurrence of disease.Methods: This study was a retrospective...

ea0032p1123 | Thyroid cancer | ECE2013

Histopathologic characterization of differentiated thyroid carcinoma in an area of Basque country

Vicente Ma Angeles Vicente , Polo Pilar Sierra , Gomez Carmen Cabrejas , Iregi IzasKun Olaizola , Cabrera Natalia Gonzalez , Gomez Clara Rosario Fuentes , Miguel Ma Angeles Anton

Background: The most common type of thyroid cancer is the well-differentiated thyroid carcinoma (DTC) and that includes papillary (PTC) and follicular carcinoma (FTC). The PTC would represent 50–90% and the FTC over 15–30%. Within the PTC, the most frequent is the classical variant (over 80%), followed by follicular variant (10%) and the rest of variants (<10%). Furthermore, there are differences between PTC and FTC in age at diagnosis, local extension, multicent...

ea0020p588 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Quality of life (QoL) in patients with Cushing's syndrome in a Spanish population: new experience with the CushingQoL questionnaire

Alicia Santos , Eugenia Resmini , Jose Barahona Ma , Camelia Marti , Cheryl Farkas , Olga Roig , Ma Antonia Martinez , Nuria Sucunza , Xavier Badia , Susan M Webb

Quality of life is impaired in patients who have suffered Cushing’s syndrome (CS).Aim: Evaluate QoL with the new questionnaire CushingQoL in Spanish patients in a clinical practice setting and compare it with a generic QoL questionnaire, EuroQoL-5 Dimensions (5D) and its Visual Analogue Scale (VAS).Patients and methods: Forty-three patients with CS (38 pituitary-dependent, 28 cured) were approached during their regular endocri...

ea0081p33 | Calcium and Bone | ECE2022

Psychometric evaluation of the hypoparathyroidism symptom diary using data from two clinical trials

Nelson Lauren , Ing Steven , Rubin Mishaela , Ma Jia , Martin Susan , Sen Rohini , Ayodele Olulade

The Hypoparathyroidism Symptom Diary (HypoPT-SD) was developed for the daily assessment of key symptoms and impact of HypoPT as reported by patients with chronic HypoPT and includes 13-items: a 7-item Symptom subscale, 4-item Impact subscale, and single-item anxiety and depression scores. The current analysis was undertaken to confirm test-retest reliability and construct validity of HypoPT SD Symptom subscale scores using data collected during two open-label, single-arm studi...