Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps2-16-03 | Thyroid Cancer clinical 2 | ETA2023

The incidence of thyroid cancer in europe: A meta-analysis

De Villalonga Beatriz , Volpi Federico , Chumbiauca Estefania , Garcia Marta , Guillen-Grima Francisco , Carlos Galofre Juan

Background: The incidence of thyroid cancer (TC) has been increasing in recent years while mortality has remained stable. The cause of this increase is unclear, although several hypotheses have been proposed. While the increased incidence may only be apparent due to increased testing, there is data that suggest that there may be a real increase in incidence related to different risk factors. The aim of this meta-analysis was to determine the current incidence of TC in Europe.<...

ea0099p593 | Late-Breaking | ECE2024

Calcaneal quantitative ultrasound as a screening tool in patients with acromegaly

Casabella Andrea , Campana Claudia , Nista Federica , Milioto Angelo , Ferone Diego , Paolino Sabrina , Gatto Federico

Introduction: Patients with acromegaly have an increased fracture risk, particularly vertebral fractures. Growth hormone (GH) excess, and the related increase of IGF-1 levels, have been shown to impair bone microarchitecture more than bone density. Therefore, the assessment of trabecular bone score (TBS) has been recommended beside standard dual-energy X-ray absorptiometry (DXA). The calcaneal quantitative ultrasound (QUS) is less expensive and more accessible compared to DXA,...

ea0099ep318 | Pituitary and Neuroendocrinology | ECE2024

Liraglutide regulates expression of enzymes involved in carbohydrate and lipid metabolism in brain cortex of female rat pups under maternal perinatal food restriction

Mastoor Zainab , Carmelo Gonzalez-Matias Lucas , Ferrer Federico , Diz-Chaves Yolanda

Introduction: The regulation of glucose and lipid metabolism in the brain is essential to ensure overall neurological health and proper functioning. Increased glycolysis and lipogenesis, if not properly regulated, can potentially lead to an imbalance between energy production in the brain. Glucose and lipid metabolic dysregulation contribute to the development and progression of various brain diseases. Besides other factors maternal undernutrition may alter glucose and lipid m...

ea0081p254 | Late-Breaking | ECE2022

Facial phenotype changes and its impact in Quality of Life of acromegaly patients

Ferrer Laura , Antonia Martinez-Momblan Maria , Marques-Pamies Montse , vazquez Federico , Soldevila Berta , Ciriza Raquel , Valassi Elena , Puig-Domingo Manel

Acromegaly is a rare disease usually diagnosed late in disease evolution. It implies for skeletal changes of most flat bones including those of the skull. Consequently, a progressive facial disfiguration occurs at slow velocity of irreversible nature. Even after curation most of these changes stay for the whole life of the patient.Aim: to study the potential relationship between disfiguring facial modifications and psychosocial and Quality of Life (QoL) ...

ea0081ep826 | Pituitary and Neuroendocrinology | ECE2022

Looking for a safe and effective drug: the troubled journey of a Cushing’s Disease patient

Milioto Angelo , Cocchiara Francesco , Corica Giuliana , Khorrami Keyvan , Nista Federica , Criminelli Diego , Zona Gianluigi , Ferone Diego , Gatto Federico

Cushing’s Disease (CD) is severe clinical condition due to an ACTH-secreting pituitary tumor. Here we present the case of a 25-years old male who came to our attention for hypertension, moon face, acanthosis nigricans, abdominal purple striae and central obesity. The diagnosis of CD was based on the presence of high plasma cortisol after dexamethasone suppression test and elevated urinary free cortisol levels (UFC, 6-fold higher the upper limit of normality (ULN)). The pi...

ea0090p415 | Pituitary and Neuroendocrinology | ECE2023

Synchronous multiple pituitary neuroendocrine tumors (PitNETs) consisting of a null cell and PIT-1 lineage adenomas: a peculiar acromegalic case report

Bruco Alessia , Zoli Matteo , Melotti Sofia , Ribichini Danilo , Pizza Gianmarco , Mao Federico , Mazzatenta Diego , Asioli Sofia , Pagotto Uberto

Pituitary adenomas constitute the third most common intracranial neoplasm. Adenoma cells either express no hormone (null cell adenoma) or hormones of different cell lineage. About 1% of pituitary adenomas shows a plurihormonal expression pattern, which may either be attributed to one cell lineage or rarely to different cell lineages. In addition, the development of separate pituitary adenomas may be observed in 0.5–1.5% of surgical specimens and in up to 10% of autopsy ca...

ea0063gp180 | Benign Thyroid Disorders | ECE2019

Urinary concentration of iodotyrosines correlates with the severity of iodine deficiency in dehal1 knockout mice

Gonzalez-Guerrero Cristian , Borso Marco , Garcia-Gimenez Jorge , Salas-Lucia Federico , Alikhani Pouya , Saba Alessandro , Zucchi Riccardo , Moreno Jose C

Thyroid hormone (TH) synthesis requires iodine, a scarce element whose recycling is mediated by DEHAL1 through deiodination of iodotyrosines MIT and DIT. In humans, DEHAL1 defects lead to severe congenital hypothyroidism (CH) non-detected by neonatal screening programs, which involves the risk of mental retardation in infants. The timing for establishment of this hypothyroidism remains unknown, but environmental iodine deficiency may represent a triggering factor. Whi...

ea0049ep789 | Endocrine tumours and neoplasia | ECE2017

Magmas modulates chemoresistance in endocrine-related cancers

Riva Eleonora , Tagliati Federico , Gagliano Teresa , Trapella Claudio , Missiroli Sonia , Pinton Paolo , Bertolucci Cristiano , degli Uberti Ettore , Chiara Zatelli Maria

: Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). The synthetic Compound 5 is capable of sensitizing chemoresistant tumor cells overexpressing Magmas to proapoptotic stimuli, indicating that this molecule may be useful to overcome tumor chemoresistance. The aim of our study was to evaluate whet...

ea0041oc11.3 | Bone &amp; Calcium Homeostasis | ECE2016

Ultra-trail marathon induces bone response in association with acute and established metabolic changes

Lombardi Giovanni , Sansoni Veronica , Perego Silvia , Vernillo Gianluca , Schena Federico , Merati Giampiero , Baruti Andrea , La Torre Antonio , Banfi Giuseppe

Introduction: Bone and energy metabolisms are deeply related determining a two-way street aimed in regulating the energy utilization [1]. Mountain ultra-marathons are peculiar aerobic performances hardly proving whole body homeostasis [2]. In this study we aimed at investigating and characterizing the metabolic profile (hormones involved in energy metabolism), the metabolic inflammation profile (adipokines), the bone metabolism (bone turnover markers), and their integration (m...

ea0041ep107 | Bone &amp; Osteoporosis | ECE2016

Bone microarchitecture assessed by trabecular bone score in liver transplants with New-Onset Diabetes after transplantation

Librizzi Maria Soledad , Allo Gonzalo , Sierra Milagros , Aramendi Mercedes , Guadalix Sonsoles , Jimenez Carlos , Diaz-Guerra Guillermo Martinez , Hawkins Federico

Background: The increased risk for fractures in type 2 diabetes mellitus despite higher bone density is unexplained. Trabecular bone score (TBS) is a novel texture index related to bone microarchitecture and it is independent of bone mineral density (BMD). The aim of this study was to investigate the relationship between TBS, BMD and body composition in patients with New-Onset Diabetes after transplantation (NODAT).Methods: In a cross-sectional study, TB...