Searchable abstracts of presentations at key conferences in endocrinology

ea0059cc8 | Featured Clinical Cases | SFEBES2018

Clinical and biochemical acromegaly associated with pituitary FSHomas

Huang Doran Isabel , Koulouri Olympia , Oddy Sue , Halsall David , O'Donovan Dominic , Roncaroli Federico , Mannion Richard , Allinson Kieran , Gurnell Mark

Acromegaly is a clinical manifestation of excessive peripheral growth hormone (GH) action. Most cases result from pituitary somatotroph adenomas displaying varying degrees of GH immunoreactivity. Occasionally, GH is cosecreted with a second hormone from adenomas containing mixed cell populations (e.g. somatolactotroph tumours). Coexistence of multiple discrete adenomas, identical or distinct in hormone secretion, is infrequent. In very rare cases, acromegaly results from neuro...

ea0037gp.17.02 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Glp-1 regulates the reproductive function and synchronizes the onset of the puberty in female rats

Iglesias Veronica Outeirino , Perez Marina Romani , Gomez Juan Fandino , Matias Lucas Carmelo Gonzalez , Ferrer Federico Mallo , Gago Eva Maria Vigo

GLP-1 is a gut hormones with insulinotropic effects. GLP-1 is expressed at the hypothalamus having regulatory functions in food intake and neuroendocrine corticoadrenal axis (HPA). Energy balance and HPA have deep influence in the gonadal function of mammals. Exendin-4 (Ex4) is a potent agonist for the GLP-1 receptor.Objectives: To evaluate the effects of native GLP-1 (7–36)-NH2(GLP-1) and Ex4 in the function of the reproductive system in adulthood ...

ea0037ep433 | Diabetes (complications & therapy) | ECE2015

Association between cardiovascular disease and microvascular complications in diabetic patients

Miguel Gonzalo Allo , Fernandez Elena Garcia , Rodriguez Juan Carlos Romero , Diaz-Guerra Guillermo Martinez , Carranza Federico Hawkins

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of cardiovascular complications. It is, also, well known that diabetes confers a substantial burden of microvascular disease. Previous studies suggest a link between microvascular and macrovascular events in diabetes. However, just a few studies have investigated whether the presence of previous cardiovascular events is associated with microvascular disease in diabetes patients. So, this is th...

ea0037ep773 | Pituitary: clinical | ECE2015

Clinical characterisation of acromegaloidism in a controlled prospective study

Catalina Pablo F , Guanipa Wilfredo , Paramo Concepcion , Gonzalez Enrique Suarez , Matias Lucas Gonzalez , Alvarez Elias , Mallo Federico

Acromegaloidisms are usually reported as isolated cases that are not well characterised clinically. Indeed, most such cases were reported several decades ago, part of the reason why our knowledge about this entity is scarce. By contrast, clinical situations suggestive of acromegaly are not so infrequent, in which basal GH and IGF1 levels lie within a normal range, the GH responses to OGTT challenge are conserved and there is no radiological (MRI) evidence of hypothalamic-pitui...

ea0035p831 | Pituitary Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Functional characterization of a new deletion in CDKN1B 5′-UTR region

Ruvo Mauro Di , Tagliati Federico , Gentilin Erica , Gagliano Teresa , Pellegata Natalia , Benfini Katiuscia , Uberti Ettore degli , Zatelli Maria Chiara

Introduction: CDKN1B gene, which encodes a cyclin-dependent kinase (Cdk) inhibitor, regulates the progression throughout G1 to S cell cycle progression. CDKN1B loss-of-function germinal mutations cause the multiple endocrine neoplasia type 4 syndrome (MEN4).Objective: The aim of the study is the functional characterization of a new 4 bp deletion in CDKN1B 5′-UTR region, identified in an acromegalic patient.Materials and metho...

ea0035p1007 | Thyroid (non-cancer) | ECE2014

The metabolic syndrome, and not obesity, is associated with fasting TSH in euthyroid obese children and adolescents

Martucci Federico , Magni Serena , Rossetti Paola , Manzoni Giuseppina , Di Candia Stefania , Weber Giovanna , Frittitta Lucia , Bonfanti Riccardo , Perseghin Gianluca

Increased serum TSH has been reported in obese children and adolescents and is considered an adaptive mechanism secondary to obesity. This study was undertaken to test the hypothesis that this adaptation is not associated with obesity per se but with its related metabolic alterations. Using a cross-sectional approach, we collected retrospectively fasting serum TSH concentration (if within the normal range), anthropometric parameters and criteria for the diagnosis of t...

ea0035p1138 | Thyroid Cancer | ECE2014

Prognostic factors in 213 patients with differentiated thyroid cancer

Librizzi Maria Soledad , Guadalix Sonsoles , Partida Miriam , Ferrero Jorge , Ferrero Eduardo , Perez-Barrios Andres , Martinez Guillermo , Hawkins Federico

Objectives: Prognosis of differentiated thyroid carcinoma (DTC) is usually good, but even so a proportion of the patients develop recurrences and eventually die of the disease. The aim of this study was to analyze the clinical and histopathological features of patients with DTC in our center and to identify prognostic factors in this group of patients.Patients and methods: We reviewed, retrospectively, 213 patients (184 females and 29 males, mean age 48....

ea0032p288 | Clinical case reports - Thyroid / Others | ECE2013

Clinical case report: male patient with SRY-positive 46,XX testicular disorder of sex development

Dominguez-Lopez Marta , Gonzalez-Molero Inmaculada , Esteva Isabel , Gonzalo-Marin Montserrat , de Adana MSoledad Ruiz , Soriguer Federico

The 46 XX male syndrome (de la Chapelle syndrome or 46,XX testicular disorder of sex development -46,XX testicular DSD-) is a rare phenotype associated with disorder of the sex chromosomes. XX males exist in different clinical categories with ambiguous genitalia or partially to fully mature male genitalia, in combination with complete or incomplete masculinization.Clinical report: We describe the clinical, molecular, and cytogenetic findings of a 26-year...

ea0032p463 | Diabetes | ECE2013

Clinical usefulness of a bolus calculator in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion (CSII)

Dominguez-Lopez Marta , Gonzalez-Molero Mercedes Inmaculaca , Guerrero Inmaculaca , Gonzalez Stella , Adana MSoledad Ruiz de , Soriguer Federico

Objective: One of the major problems related to the use of CSII, or intensive insulin regimens in general, is the calculation of accurate insulin boluses. Abolus calculator incorporated into the insulin pump, estimates the dose of insulin to be administered at the meal on the basis of the following parameters: current blood glucose, grams of carbohydrate in the meal, carbohydrate to-insulin ratio (CIR), insulin sensitivity factors (ISF), target blood glucose and quantity of in...

ea0032p486 | Diabetes | ECE2013

Evaluation of adolescents with type 1 diabetes after transition from paediatric to adult care

Dominguez-Lopez Marta , Gonzalez-Molero Inmaculada , Lopez-Siguero Juan Pedro , Navas MSoledad Ruiz de Adana , Escofet Federico Soriguer

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...