Searchable abstracts of presentations at key conferences in endocrinology

ea0020p173 | Endocrine tumours and neoplasia | ECE2009

Von-Hippel-Lindau disease: clinical report

Santos Jacinta , Paiva Isabel , Martinho Mariana , Vieira Alexandra , Vieira Diniz , Cunha Lurdes , Martinho Fernando , Carvalheiro Manuela

Background: Von-Hippel-Lindau disease (VHL) is a rare (1/36.000 newborns), autosomal, dominant inherited tumour syndrome. A germline mutation in VHL tumour suppressor gene predisposes carriers to tumours in multiple organs. In the presence of positive family history, it can be diagnosed clinically in a patient with at least one typical VHL tumour.Clinical report: In December 2007, a 34 years-old women presented with palpitations and tachycardia, but norm...

ea0066p50 | Diabetes 5 | BSPED2019

Use of flash glucose monitoring during hypo/hyperglycaemia and to guide insulin administration in paediatric patients with type 1 diabetes

Jordan Kate , Bound Christopher , Vieira Soraia , Wassouf Samir , Watson Mando

Introduction: Flash glucose monitoring is increasingly used in the management of T1DM. Although the FreeStyle Libre reduces the overall burden of conventional self-monitoring of blood glucose, capillary glucose should be checked at times of Libre-predicted extreme hypo/hyperglycaemia.Methods: Consenting FreeStyle Libre users completed a structured questionnaire via phone interview. Users reported incidence of extreme hypo/hyperglycaemia (indicated by LO/...

ea0035p95 | Bone and Osteoporosis | ECE2014

Osteoporosis in young male secondary to cancer treatment: case report

Simoes-Pereira Joana , Silva-Vieira Margarida , Pereira Maria Conceicao

Introduction: Children undergoing treatment for cancer are prone to several long-term endocrine complications, which can permanently affect bone tissue.Case report: A 25-year-old man was diagnosed with right maxillary sinus rhabdomyosarcoma at the age of 5. He was submitted to chemotherapy – intrathecal methotrexate+prednisolone and i.v. vincristine+actinomycin+ifosfamide – and submaxillary+cervical radiotherapy, 60Gy. At the age of 12, he was ...

ea0035p1146 | Thyroid Cancer | ECE2014

Long-term follow-up of young patients submitted to radiotherapy: analysis of ten thyroid cancer cases

Simoes-Pereira Joana , Silva-Vieira Margarida , Pereira Maria Conceicao

Introduction: The increasing risk of thyroid cancer (TC) in patients who underwent radiotherapy is well documented, especially at early ages. In our center, young patients undergoing cancer treatments are referenced to Endocrine Rehabilitation Clinics (ERC). Their risks are initially identified and monitored regularly. We intended to analyze the characteristics and outcomes of patients who developed post-radiotherapy TC.Methods: Medical records of patien...

ea0070ep488 | Thyroid | ECE2020

Simultaneous papillary and medulary thyroid carcinoma – how to approach?

Martins Diana , Guelho Daniela , Vicente Nuno , Ventura Mara , Vieira Alexandra

Introduction: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are distinct neoplasms, associated with different histological findings. Their coexistence in the same patient is a rare event, requiring a different clinical approach.Clinical case: A 72-year-old patient with no family history of thyroid disease, underwent total thyroidectomy in February 2019, due to toxic multinodular goitre, with no evidence of postoperative complica...

ea0032p1067 | Thyroid (non-cancer) | ECE2013

Marine–lenhart syndrome

Esteves Cesar , Neves Celestino , Vieira Tiago , Pereira Jorge , Carvalho Davide

Introduction: The Marine–Lenhart syndrome is a rare cause of hyperthyroidism that is associated with the simultaneous or sequential presence of characteristics related to Graves’ disease and toxic nodular or multinodular goiter. It’s validity as a disease is controversial and some authors believe that these are cases of hyperthyroidism where both etiologies coexist. The presence of hyperfunctioning nodules in Graves’ disease patients ranges between 0.8 and ...

ea0020p216 | Endocrine tumours and neoplasia | ECE2009

Insulinomas: experience of Coimbra’s University Hospital, Endocrinology Department

Santos Jacinta , Paiva Isabel , Martinho Mariana , Vieira Alexandra , Carvalheiro Manuela

Background: Insulinomas are rare neuroendocrine tumours (4 cases/million patients per year), representing an important cause of hyperinsulinemia. Usually are benign and sporadic, but can be part of multiple endocrine neoplasias. To establish the diagnosis it is essential to document inappropriately high levels of insulin during episodes of hypoglycaemia.Aim: Retrospective analysis of the clinical files of the patients followed in our department since Jan...

ea0073aep217 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

In the context of acute disease does the same hyperlactatemia cut-off point hold similar meaning in patients with and without Diabetes mellitus? A retrospective study

Inês Vieira , Petrova Maja , José Moura

IntroductionHyperlactatemia is defined by a lactate value > 2 mmol/l and a lactate value above > 4 mmol/l is commonly used to define more severe hyperlactatemia. It is a common disorder in critically ill patients, associated with adverse prognosis. Diabetes mellitus (DM), however, can also be associated with increased lactate levels at baseline.ObjectivesTo document the development of severe hyperlact...

ea0081p499 | Thyroid | ECE2022

Variation of anti-TSH receptor antibodies after iodine-131 therapy

Vieira Ines , Monteiro Martim , Soeiro Paula , Rodrigues Dircea , Costa Gracinda , Paiva Isabel

Introduction: Graves’ disease (GD) is a systemic autoimmune disease characterized by lymphocyte activation and synthesis of anti-TSH receptor antibodies (TRABs). Higher values of TRABs are associated with a higher risk of Graves’ ophthalmopathy and dermatopathy. Iodine-131 therapy (RAI) is one of the well-established options in GD, but it can cause a transient increase in TRABs.Objectives: To evaluate the evolution of TRABs after RAI; to identi...

ea0081ep769 | Pituitary and Neuroendocrinology | ECE2022

A challenging case of sheehan syndrome

Rita Elvas Ana , Vieira Ine s , Melo Miguel , Rodrigues Di rcea , Gomes Maria Leonor , Paiva Isabel

Introduction: Sheehan Syndrome (SS) is a cause of hypopituitarism resulting from postpartum pituitary infarction. Its frequency is decreasing worldwide, particularly in developed countries due to advances in obstetric care. Case report: A 50-year-old female patient was admitted to the emergency department with complains of progressive pain in the lower hemithorax and abdomen. She also referred constipation, weight gain and asthenia. The initial laborator...