Searchable abstracts of presentations at key conferences in endocrinology

ea0019p145 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Autocrine/paracrine regulation of visfatin induced MCP-1: enhanced pro-angiogeneic effects of visfatin in the human endothelium

Adya Raghu , Tan Bee , Chen Jing , Randeva Harpal

Objectives: Visfatin and monocyte-chemoattractant-protein-1 (MCP-1) are elevated in cardiovascular pathologies, insulin-resistant and dysmetabolic states. Visfatin has been reported to exhibit pro-angiogenic actions in human endothelial cells by the induction of endothelial gelatinases and VEGF. Given MCP-1’s well described pro-angiogenic properties we sought to study the potential interaction between visfatin, MCP-1 and VEGF in human endothelial cells. More importantly, ...

ea0016oc6.3 | Metabolism and cardiovascular | ECE2008

Visfatin induces MMP-2/9 activation in human vascular endothelial cells via nuclear factor-κB

Adya Raghu , Tan Bee , Chen Jing , Randeva Harpal

Aim: Cardiovascular disease is more common in individuals with diabetes mellitus and obesity. Visfatin is elevated in obesity and T2DM; and thought to be an inflammatory mediator within atherosclerotic lesions inducing gelatinase activity, contributing to plaque destabilisation. We investigated the activation of NF-κB, a well-known pro-inflammatory transcription factor, by visfatin, in Human Endothelial Cells (EC).Research design and methods: We sta...

ea0028p167 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

The Hepatokine Fetuin-A is increased in PCOS women. Association with metabolic syndrome and regulation by metformin

Aghilla Mohamed , Adya Raghu , Tan Bee , Lehnert Hendrik , Ashawesh Khaled , Randeva Harpal

Introduction: Polycystic Ovary Syndrome (PCOS) is associated with insulin resistance, visceral obesity -metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD). Fetuin-A, human protein: α2-Heremans-Schmid glycoprotein is an abundant serum protein exclusively expressed in the liver and has been suggested to act as a link between obesity, insulin resistance (IR), and MS.Aims: A) To determine levels of Fetuin-A in PCOS women. B) To invest...

ea0019oc7 | Young Endocrinologist prize session | SFEBES2009

In vivo and ex vivo regulation of Visfatin production by leptin in human and murine adipose tissue: role of the PI3K and MAPK pathways

Tan Bee , Chen Jing , Brown James , Adya Raghu , Ramanjaneya Manjunath , Bailey Cliff , Lehnert Hendrik , Randeva Harpal

Apart from its role in energy storage, adipose tissue produces several hormones and cytokines termed ‘adipokines’ that have wide-ranging effects on carbohydrate and lipid metabolism; and thereby, play an important role in the pathogenesis of the metabolic syndrome. Visfatin is a novel adipokine, levels of which increase in obesity and is adipogenic; properties common to that of leptin. Thus, leptin may modulate visfatin production in adipose tissue. We investigated t...

ea0016p534 | Obesity | ECE2008

Insulin and glucose regulates omentin-1, a novel adipokine: relation to women with the polycyastic ovary synfrome

Tan Bee K , Adya Raghu , Farhatullah S , Lewandowski KC , O'Hare Paul , Lehnert Hendrik , Randeva Harpal S

Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Recent studies have shown that plasma omentin-1 levels decrease with obesity. Currently, no data exists on the relative expression and regulation of omentin-1 in adipose tissue (AT) of PCOS women.Objectives: To assess mRNA and protein levels of omentin-1 in omental (om) AT of PCOS women and matched controls, including circulating omentin-1. Ex vivo and in vivo</...

ea0019oc23 | Cardiovascular metabolism | SFEBES2009

Insulin increases and metformin decreases the novel adipokine chemerin in insulin resistant subjects: PCOS as a paradigm

Tan Bee , Chen Jing , Adya Raghu , Kaur Jaspreet , Heutling Dennis , Lewandowski Krzysztof C , Lehnert Hendrik , Randeva Harpal

Adipose tissue produces several hormones and cytokines termed ‘adipokines’ that have widespread effects on carbohydrate and lipid metabolism. They appear to play an important role in the pathogenesis of insulin resistance, diabetes, and atherosclerosis. Chemerin is a novel adipokine, highly expressed in obese, insulin-resistant subjects. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. We assessed chemerin levels in sera and adipose...

ea0059p170 | Obesity &amp; metabolism | SFEBES2018

Effects of visfatin on brown adipose tissue energy regulation

Dimitriadis Georgios K , Adya Raghu , Tan Bee K , Jones Terence A , Menon Vinod S , Ramanjaneya Manjunath , Kaltsas Gregory , Miras Alexander D , Randeva Harpal S

The role of brown adipose tissue (BAT) in pathological states of energy homeostasis and impaired adipocyte function, such as obesity has been a major area of research interest in recent years. Herein, we sought to determine the direct effects of adipokines, visfatin and leptin on BAT thermogenesis. The effects of mouse recombinant visfatin, nicotinamide mononucleotide (NMN) and leptin with or without FK866 were studied on differentiated T37i cells. Treated cells were analyzed ...