Endocrine Abstracts

Objective: Agranulocytosis to the antithyroid drugs is a rare adverse drug effect exposure to potentially lethal infections. It is a public health problem with hyperthyroidism in nearly 1% of the French population. However, many uncertainties remain in the knowledge, understanding, prevention and management of this drug effect. In this work, we report the French experience through pharmacovigilance data.Materials and methods: This is a retrospective stud...

Due to experimental advantages such as its rapid development, transparent embryos, and accessibility for genetic analysis as well as embryonic manipulation, the zebrafish is a useful model organism for research on organogenesis. My lab has established that the basic mechanisms of thyroid development are essentially conserved on the morphological as well as on the molecular level between fish and mammals. We use zebrafish to identify as yet unknown factors involved in thyroid d...

KLF11 is a pancreas enriched member of the Sp1/KLF transcription factor family which plays an important role in mammalian gene regulation. Previously we demonstrated that human (h)KLF11) inhibits human insulin promoter (hInsP) activity in rodent beta-cell lines via an unknown mechanism. Here we present results from ongoing experiments in which we test the hypothesis that KLF11 interferes with the major hInsP transactivator PDX1. We performed transient cotransfections of INS-1E...

Within the exocrine pancreas, p8 expression is induced by pancreatitis and protects exocrine tissue from inflammatory damage via inhibition of NFκB. In previous work, we investigated the role of p8 within the endocrine pancreas and characterised p8 as a glucose-dependent mediator of beta cell proliferation. Here we investigate the hypothesis that p8 protects beta cells from cell damage by the diabetogenic drug STZ. We investigated native and transiently transfected INS-1E...

Background: Medullary thyroid cancers (MTC) originate from parafollicular C cells and constitute 3-5% of all thyroid cancers. Calcitonin (CT) measurement is useful in the diagnosis of MTC. The sensitivity and specificity of CT are low in the measurement alone, and the sensitivity and specificity increase when used with pentagastrin and calcium stimulation tests. However, the difficulty of accessing pentagastrin, the uncertainty of the cut-off value in calcium stimulation tests...

Aim: Although thyroid nodules located in isthmus were less frequent, papillary thyroid cancer in this location was reported to be more aggressive in some studies. Our aim was to evaluate hormonal, ultrasonographic, and cytopathologic features of nodules located in isthmus (isthmic nodules).Material and methods: Data of patients who underwent thyroidectomy between 2006–2014 were reviewed retrospectively. Hormonal, ultrasonographic, and cytopathologic...

Introduction: The risk of malignancy in thyroid nodules is reported by the Bethesda system by performing fine needle aspiration biopsy (FNAB). Atypia of undetermined significance(AUS) or follicular lesion of undetermined significance(FLUS)(Bethesda 3) and suspicious for a follicular neoplasm (Bethesda 4) create uncertainty about treatment and follow-up. Molecular tests, ultrasonographic features of the nodules, and calcitonin level help us for this uncertainty. Here, we will p...