Endocrine Abstracts

Introduction: Ganglioneuroma is a rare benign tumour arising from neural crest sympathogonia. It is usually asymptomatic and non functional. An association between ganglioeneuroma and genetic or autoimmune diseases such as Addison’s disease or Mediterranean fever has never been described.Case description: We report the case of a 24-year-old woman presenting with paroxysmal abdominal pain with loss of weight and no fever. Physical examination along w...

Introduction: In Tunisia, only about 10% of people with diabetes practice self-injecting insulin analogues. It is 1 Tunisian adult out of 11 who is affected directly by diabetes. Our goal is to assess diabetes patients’ knowledge of insulin injection techniques.Patients and methods: Prospective study of 56 cases of type 2 diabetic patients in the Endocrinology Department CHU Hedi Chaker Sfax Tunisia. All patients had a questionnaire and clinical exa...

Introduction: Disorders of sex development (DSD) is a congenital condition in which the development of chromosomal, gonadal or genital sex is atypical. A female appearance patient with secondary amenorrhea and 46 XY karyotype seems to be solid evidences to diagnose Y-chromosome-related DSD diseases, while it is not necessarily the accurate diagnosis. We here report a case of a 16- year-old girl with secondary amenorrhea and 46 XY karyotype after bone marrow transplantation (BM...

Introduction: Adrenal cystic lesions are uncommon and mostly identified incidentally during radiological investigations or at surgery for unrelated reasons. Its incidence varies between 0.064 and 0.18%. Adrenal cysts are classified as endothelial cysts, pseudocysts, epithelial cysts, and parasitic cysts.Case report: A 45-year-old female with a past medical history of systemic hypertensive disease for 2 years, presented with recurrent abdominal pain durin...

The present study aimed to investigate the effect of time-of-days (TOD) on some biochemical and hormonal responses after resistance training sessions.Methods: Ten trained subjects performed three resistance-training-sessions at 0700 h, 1300 h and 1700 h. Each training-session included six upper and lower body resistance exercises with 3×10 repetitions. Blood lactate (Lac), creatine kinase (CK), lactate dehydrogenase (LDH), cortisol (C) and testoster...

Introduction: The association of primary hyperparathyroidism (PHPT) and hyperthyroidism secondary to toxic multinodular goiter (TMNG) is rarely described in the literature. Hereby, we describe the clinical, biological, and radiological characteristics of two patients having this rare association.Observations: First case: A 66 years-old female was diagnosed with primary hyperthyroidism. Her thyroid antibodies were negatives. During the follow-up, she pres...

Introduction: The simultaneous occurrence in the same patient of more than one endocrinological condition is rare and was described in the multiple endocrine neoplasia (MEN). Here, we report a patient with an unusual combination of primary-hyperparathyroidism, papillary thyroid microcarcinoma, primary-hyperaldosteronism and ACTH-independent Cushing’s syndrome.Case description: A 54-year-old women with a primary-hyperparathyroidism was admitted to ou...

Adrenocortical carcinoma (ACC) is a rare malignancy, accounting for 0.02% of all annual cancer. The majority of these tumors are benign, non-functioning adenomas that are incidentally discovered on abdominal image studies. Others are functional adenomas secreting cortisol, aldosterone, or less commonly androgens or estrogens. Pure androgen-secreting adrenal tumors are very rare.Case report: A 34-year-old female patient presented with pain in the left upp...

Introduction: The metabolic stressor, hypoglycemia, elicits integrated counterregulatory responses, including activation of the hypothalamic–pituitary–adrenal axis. However, it is suggested that recurring insulin-induced hypoglycemia can impair this counter-regulation. Here we report three cases of patients with isulinoma and corticotroph deficiency.Case reports: The first case, 38-year-old man was referred because of recurrent episode...

Introduction: Multiple autoimmune syndrome (MAS) is a rare condition, first described by Humbert and Dupond in 1988 and characterised by three or more autoimmune disorders in the same individual.Case description: Here we present a case of 14-year-old female patient diagnosed with ocular myasthenia gravis. The diagnosis of Graves’ disease was suspected on the basis of hyperthyroidism symptoms and confirmed by undetectable TSH level (<0.01 mUI/l) ...