Endocrine Abstracts

Struma Ovarii and its malignant transformation to thyroid-type carcinoma are rare conditions. In recent reviews of reported literatures, only 53 cases of papillary thyroid-type carcinoma arising from struma ovarii were documented from 1924 to 2008. Due to the rarity of the disease, lack of uniform histological criteria for malignancy and protracted clinical course, its management is not also universally accepted by physicians. The aim of this paper is to present a very rare ca...

Background: Leptospirosis is an endemic zoonosis in the Philippines, with complications including jaundice from liver injury and acute kidney injury requiring renal replacement therapy. On the other hand, thyroid storm, most commonly in the setting of Graves’s disease, is a rare complication of hyperthyroidism. To date, thyroid storm has not been documented in patients with severe leptospirosis.Case Presentation: Herein, we present the case of a 52-...

Pseudohypoglycemia has been reported in patients with Raynaud’s phenomenon, peripheral vascular disease and shock and may result from increased glucose extraction by the tissues because of low capillary flow and increased glucose transit time. We present a frail and comorbid 76-year-old lady with a long standing history of Rheumatoid arthritis/systemic sclerosis/systemic lupus erythematosis overlap syndrome complicated by Raynaud’s phenomenon. She was on long-term st...

Introduction: Osteoporosis is a major cause of morbidity in β thalassaemia major patients. Our institution serves one of UK’s largest populations of thalassaemia patients. This study aimed to examine the prevalence of osteopenia and osteoporosis in thalassaemia major patients and identify risk factors for low bone mineral density (BMD).Methods: BMD of lumbar spine and neck of femur were measured using dual-emission X-ray absorptiometry (DEXA). ...

We report two rare cases of well differentiated thyroid-type carcinoma arising from struma ovarii managed in our institution.Case 1: A 41-year-old female admitted due to abdominal pain and vomiting. Her abdomen was globular with palpable vague mass on lower abdomen. Ultrasound scan revealed 12.5×12.1×8.3 cm heterogenous mass with ascites. Total abdominal hysterectomy with bilateral salphingo-oophorectomy was done and histopathology results reve...

This is a case of an adult female who presented with 1 year history of palpitations, heat intolerance, easy fatigability, hyperdefecation and proptosis. She was admitted to this institution due to 3 month history of nausea, vomiting, abdominal pain, flank pain and generalized weakness. During admission, she was diagnosed with hyperthyroidism supported by laboratory findings of suppressed thyroid stimulating hormone and elevated free thyroxine levels and was then treated with m...

Aims: Low vitamin D levels may contribute to the pathogenesis of bone disease in thalassaemia major patients. Our haematology department serves one of the UK’s largest populations of thalassaemia patients. We evaluated our thalassaemia major patients’ vitamin D levels and other serum bone markers.Methods: Blood specimens were collected from all thalassaemia major patients under active follow-up in March and April 2010 and serum 25-OH-vitamin D,...

Aims: Endocrine deficiencies are common complications of thalassaemia major. Our haematology department serves one of the UK’s largest populations of thalassaemia patients. We assessed our thalassaemia major patients’ endocrine status and factors associated with endocrinopathies.Methods: Retrospective analysis of our thalassaemia major patients on active follow-up in April 2010. Parameters such as age, gender, hepatitis C infection, compliance ...

Introduction: Despite its high vascularity, metastases to the thyroid is rare. The frequency of metastasis in routine practice is less than 0.2% of thyroid malignancies.Clinical case: An ambulatory 48-year-old male presented with a two-month history of enlarging anterior neck mass that moves with deglutition, slowly growing in size, associated with hoarseness later in the course of the disease. He had no pertinent past medical history. Fine needle aspira...

Background and Aims: Non-alcoholic fatty liver disease (NAFLD), a leading cause of cirrhosis and liver cancer, is increasing worldwide due to rising obesity rates, particularly in Asia. Weight loss induced with diet and exercise decreases hepatic steatosis and inflammation, but requires greater efforts to sustain compared to medication. We therefore aimed to compare the effects of liraglutide, a glucagon-like peptide-1 agonist which induces weight loss, on hepatic steatosis an...