Endocrine Abstracts

Introduction: Besides the benefits of low-to-high intensity physical activity (PA) on metabolism, it is currently emerging that excessive PA can be deleterious with serious implications not only in muscle but also, bone remodeling. Despite recent findings remains still unclear and controversial, we hypothesize that exercise of impact, like mountain cycling, beyond influencing the metabolic and skeletal profile, represents an important model of profoundly changes in bone metabo...

Introduction: The long-term mountain cycling effects on cognitive development for better performance, are still not fully elucidated. Notwithstanding, this type of exercise may induce a link with energy metabolism and sympathetic nervous system. We previously observed that a mountain cycling ultramarathon, induced a comodulatory influence of genetic- and exercise-associated factors on inflammatory and haemoglobin catabolic marker haptoglobin. We hypothesised that inflammatory ...

Introduction: The interaction between bone and energy metabolism may be enhanced in high demanding physical activities. We hypothesize that genetic background may modulate the exercise-associated bone and energy responses of athletes participating of a mountain cycling ultramarathon.Methods: Fifty-five non-professional athletes (mean age 44.8±7.1 years) participating in a 9-day mountain cycling ultramarathon (TransPortugal) were evaluated. Before an...

Introduction: Eating habits may contribute to longevity. Consumption of red meat, source of saturated fatty acids and cholesterol may be associated with increased risks of diabetes, cardiovascular disease (CVD), and mortality risk.Methods: We studied 521 subjects, both genders, 253 centenarians (CENT) (100.26±1.98 age) and 268 controls (67.51±3.25 age), both low (LCR) and high cardiovascular risk (HCR), calculated based on QRISK®2-2016. An...

Introduction: Fat-free mass has a functional significance in aging. The objective of this study was to evaluate the prevalence of underweight in a Portuguese population of centenarians and their relationship with dehydration or sarcopenia.Methods/design: Anthropometric data were obtained using standard procedures from 252 centenarians (100.26±1.99 years), 77.8% women (W). Body composition was assessed by tetrapolar bioimpedance. It was considered de...

Objectives: The angiotensin-converting enzyme (ACE1) gene is one of the most studied genes in the pathogenesis of type II diabetes (T2DM) and cardiovascular disease. However, in the context of exerciSemodels in T2DM, they are not yet fully understood. We intended to characterize the genetic profile of individuals with T2DM from an inter-individual point of view using prognostic markers and cardiovascular risk. On the other hand, relate it with the profile obtained wit...