Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep156 | Calcium and Bone | ECE2022

Late diagnosis of life-threatening hypocalcemia in a patient with hypoparathyroidism after hemithyroidectomy: A case report

Maghakyan Sona , Vardanyan Anna , Ghazaryan Ara , Aghajanova Elena

Introduction: Hypocalcemia is defined as a decreased level of calcium in the blood. The presentation of hypocalcemia varies widely, from asymptomatic to life-threatening. The most common cause of chronic hypocalcemia is postsurgical hypoparathyroidism. This may occur after removal of all parathyroid tissue during thyroidectomy and radical neck dissection for malignancies or after inadvertent interruption of the blood supply to the parathyroid glands during head and neck surger...

ea0073aep96 | Calcium and Bone | ECE2021

Normocalcemic primary hyperparathyroidism – an early stage of hypercalcemic hyperparathyroidism?

Bárbara Filipa Araújo , Ferreira Sara Esteves , Rodrigues Teresa , Cátia Andreia Araújo , Lúcia Fadiga , Paiva Sandra , PAIVA Isabel

IntroductionPrimary hyperparathyroidism (PHPT) is a common endocrine disorder and classically associated with hypercalcemia (HHPT). There is a newest variant of PHPT, defined by normal albumin-corrected calcium levels - normocalcemic PHPT (NHPT) – which may represent an early stage of HHPT. Nevertheless, there is limited data on how this variant presents clinically and biochemically.AimTo evaluate the de...

ea0073aep198 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Elderly patients with Type 2 Diabetes and Covid-19: the impact of glycemic control on the outcomes

Cátia Andreia Araújo , Bárbara Filipa Araújo , Melo Miguel , Baptista Carla , Paiva Sandra , Paiva Isabel

IntroductionDiabetes mellitus (DM) is one of the major comorbidities in patients with Coronavirus disease (COVID-19) leading to poorer outcomes. Previous evidence showed that poorly-controlled hyperglycemia increases the severity and mortality of COVID-19. Nevertheless, there is limited data on the role of in-hospital glucose control on the outcomes of elderly patients with type 2 diabetes mellitus (T2DM).Objective<p class="abs...

ea0073aep273 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Acute hyperglycemic emergencies during lockdown: COVID-19 collateral damage

Bárbara Filipa Araújo , Cátia Andreia Araújo , Lavrador Mariana , Elvas Ana Rita , Paiva Sandra , PAIVA Isabel

IntroductionIn march 2020, the COVID-19 pandemic registered its first cases in Portugal, leading the government to impose lockdown, in order to prevent the spread of cases. With social isolation and outpatient activity being ceased, there was an increase in mortality of non-COVID patients. The lockdown recommendations are in contradiction with comprehensive diabetes care and reflected in less regular patient-provider interactions, which in some cases con...

ea0070aep473 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Refeeding syndrome – an unexpected clinical case

Puga Francisca , Baptista Patrícia , França Margarida , Araújo Correia João

Refeeding syndrome can be defined as the potentially fatal shift in fluids and electrolytes that may occur after the reintroduction of feeding after a period of starvation or fasting in malnourished patients. The hallmark characteristic of refeeding syndrome is hypophosphatemia. However, the syndrome is complex and may also feature abnormal sodium and fluid balance, changes in glucose, protein and fat metabolism, hypokalemia, hypomagnesemia and thiamine deficiency. The underly...

ea0073aep107 | Calcium and Bone | ECE2021

New variant of the casr gene (c.2459c > t) associated with primary hypoparathyrodism – a case report

Lavrador Mariana , Lages Adriana , Bárbara Araújo , Luísa Barros , Paiva Isabel

BackgroundAutosomal dominant hypocalcaemia, caused by either inherited or de novo mutations in calcium-sensing receptor gene (CASR), is biochemically characterized by the presence of hypocalcaemia, hypercalciuria and inappropriately low levels of PTH. Receptor-activating mutations induce an increase sensitivity to calcium by parathyroid and renal cells, leading to suppression of PTH synthesis and consequently hypocalcaemia. Clinical manifestations are va...

ea0070aep817 | Reproductive and Developmental Endocrinology | ECE2020

Hutchinson – gilford progeria syndrome – a portuguese rare case

Catarino Diana , Bastos Margarida , Ribeiro Cristina , Fadiga Lucia , Silva Diana , Guiomar Joana , Lavrador Mariana , Vieira Inês , Araújo Cátia , Araújo Bárbara , Dinis Isabel , Mirante Alice , Paiva Isabel

Introduction: Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare disease (1:4 million) characterized by a fatal premature aging. There are 162 cases worldwide, five of them in Portugal. It is caused by a sporadic autosomal dominant mutation in LMNA gene that encodes an abnormal variant of the laminin-A protein, named progerin. Although most babies born looking healthy, they begin to display some characteristics of Progeria around 18–24 months of life. The ear...

ea0070ep43 | Adrenal and Cardiovascular Endocrinology | ECE2020

Pericarditis complicated with cardiac tamponade and Addison disease – A case report

Lavrador Mariana , Cardoso Luís , Catarino Diana , Fadiga Lúcia , Silva Diana , Guiomar Joana , Vieira Inês , Araújo Bárbara , Araújo Cátia , Barros Luísa , Paiva Isabel

Introduction: Addison Disease is a rare condition with an estimated incidence in the developed world of 0.8 cases per 100 000 population. It is associated with relevant morbidity and mortality rates, but once the diagnosis is made it can be easily managed. When Addison Disease is associated with other autoimmune diseases, the diagnosis of polyglandular autoimmune syndrome can be set. The recognition of symptoms and signs can be challenging and clinicians should be aware of aty...

ea0070ep482 | Thyroid | ECE2020

Treatment with tyroisine kinase inhibitor in thyroid cancer: A single centre experience

Catarino Diana , Ribeiro Cristina , Saraiva Joana , Melo Miguel , Fadiga Lucia , Silva Diana , Guiomar Joana , Lavrador Mariana , Vieira Inês , Ferreira Sara , Araújo Cátia , Araújo Bárbara , Paiva Isabel

Introduction: Tyrosine kinase inhibitors (TKI) demonstrated clinically significant activity in radio iodine (RAI)-refractory differentiated thyroid cancer (DTC) and in locally recurrent, unresectable and metastatic medullary thyroid cancer (MTC). The natural history of MTC and DCT is quite variable with rates of disease progression ranging from a few months to many years. TKI can be associated with progression-free survival, but is not curative and the side effects may have a ...

ea0073aep247 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Clinical characteristics and outcomes of elderly type 2 diabetic patients with SARS-COV2 infection: a retrospective single centre study

Bárbara Filipa Araújo , Cátia Andreia Araújo , Melo Miguel , Lavrador Mariana , Elvas Ana Rita , Diana Alexandra Festas Silva , Guiomar Joana Reis , Paiva Sandra , PAIVA Isabel

IntroductionDiabetes mellitus (DM) and older age are frequent comorbidities as well as factors associated with poorer outcomes in patients with Coronavirus disease (COVID-19). The reason for worse prognosis in patients with diabetes is likely to be multifactorial.Objectives We aimed to evaluate clinical characteristics and their impact on the outcomes of elderly patients with and without DM hospitalized with ...