Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep748 | Neuroendocrinology | ECE2016

Severe carcinoid cardiac disease in a young patient with neuroendocrine tumor of unknown origin

Poiana Catalina , Nitu Ileana , Baciu Ionela

Carcinoid cardiac disease is a rare cause of intrinsic right heart valve disease with significant impact on mortality. We present the case of a young male patient (38 yrs old) complaining in the last 5 yrs of abdominal pain associated with flushing of the face that progressively worsened (up to 15 episodes/day) accompanied by diarrhoea and, in the last 2 months, by night sweats, distension of the abdomen, bilateral ankle swelling and progressive limitation in effort. Endocrine...

ea0090ep886 | Pituitary and Neuroendocrinology | ECE2023

Acromegaly may be associated with gynaecological and skin forms of cancer

Ioana Iulia Greere Daniela , Baciu Ionela , Capatina Cristina , Poiana Catalina

Introduction: Acromegaly is a rare disease usually caused by growth hormone (GH) secreting pituitary adenomas (PA) and associated with a series of complications, including tumours. The most prevalent tumour types are colonic adenomas, colorectal cancer (1) and nodular goiter (2). We present two acromegaly cases attending our center that associate cervical cancer and another that associates melanoma. Clinical cases: Case 1: A 56-yea...

ea0067gp28 | Poster Presentations | EYES2019

Case Report: Cushing disease developed from a nonfunctioning pituitary adenoma

Morea Alexandru , Lambrinoc Diana , Baciu Ionela , Poiana Catalina

Background: Only a few cases of pituitary tumor swift from non-functioning to Cushing disease (CD) have been previously presented in the literature. The exact mechanism is still unknown. We present a case of a patient with a non-functioning pituitary adenoma, who developed CD from the residual tumor, 13 years after the initial diagnosis and following 2 surgical interventions and radiation therapy.Case presentation: A 51-year-old woman initially presented...

ea0063p1065 | Pituitary and Neuroendocrinology 3 | ECE2019

Graves dermopathy associating toes lesion, pretibial myxedema and acropachy, rare, but aggressive extrathyroidal manifestation of Graves’ disease

Marinescu Mihai Constantin , Baciu Ionela , Alexandrescu Daniela , Poiana Catalina

Introduction: Graves’ dermopathy (also known as pretibial myxedema, thyroid dermopathy, Jadassohn-Dösseker disease or myxedema tuberosum) is a rare extrathyroidal manifestation of Graves’ disease, which is almost always associated with Graves’ ophthalmopathy. Although pretibial myxedema is the most frequent localization of Graves’ dermopathy, the involvement of toes with or without the involvement of pretibial area may occur.Obje...

ea0059p025 | Adrenal and steroids | SFEBES2018

Secondary diabetes mellitus in patients with endogenous cushing’s syndrome

Capatina Cristina , Baciu Ionela , Greere Daniela , Caragheorgheopol Andra , Poiana Catalina

Introduction: Endogenous Cushing’s syndrome (CS) is a rare disease associated with severe morbidity and increased mortality if untreated. Glucose metabolism is significantly altered in hypercortisolism.Objective: To retrospectively analyse the clinical presentation of a cohort of patients with endogenous CS and study the frequency of glucose metabolism abnormalities as opposed to other clinical signs and symptoms.Material and ...

ea0038p162 | Neoplasia, cancer and late effects | SFEBES2015

Outcome of insulinomas diagnosed in a tertiary endocrine centre

Trifanescu Raluca , Baciu Ionela , Gheorghiu Monica , Dumitrascu Anda , Poiana Catalina

Background: Insulinomas, the most common functional neuroendocrine tumours of the pancreas, are usually sporadic, benign and solitary.Aims: To assess biochemical data, localisation and treatment outcome of insulinomas diagnosed in a tertiary endocrine centre.Patients and methods: Twenty-five patients (14 F/11 M), aged 49.1±14.1 years, diagnosed with insulinoma in a Neuroendocrine Tumours centre between 2000 and 2014 were retro...

ea0038p452 | Thyroid | SFEBES2015

Diagnostic and therapeutic challenges in medullary thyroid carcinoma

Dobrescu Ruxandra , Baciu Ionela , Ioachim Dumitru , Badiu Corin

Medullary thyroid carcinoma (MTC) is an aggressive form of malignancy, virtually incurable except by complete surgical resection. With insidious onset and occasional rare clinical variants, it is often diagnosed late in the course of disease and has a poor prognosis. We aimed to evaluate diagnostic efficiency, treatment modalities and outcome in patients admitted to our department between 2004 and 2015, diagnosed with MTC, with emphasis on rare clinical presentations. We ident...

ea0081ep1050 | Thyroid | ECE2022

Metastatic papillary thyroid carcinoma - a multidisciplinary approach

Manole Tiberiu , Baciu Ionela Florina , Dumitrascu Anda , Goldstein Liviu , Poiana Catalina

Introduction: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. It represents over 80% of all follicular derived well-differentiated thyroid cancers. Despite the fact that the majority of PTCs are well differentiated and have a low rate of local invasion, recurrences, or metastases, there are complex cases which require a multidisciplinary team for a favourable result.Methods: Clinical examination, blood tests, scintigraphy, CT s...

ea0090p37 | Calcium and Bone | ECE2023

Vertebral fractures in acromegaly

Sorohan Madalina , Baciu Ionela , Galoiu Simona , Caragheorgheopol Andra , Iordachescu Carmen , Poiana Catalina

Introduction: Acromegalic bone disease is characterized by an increased prevalence of fragility vertebral fractures (VFs). However, an effective, non-invasive and cost-efficient imaging technique that can diagnose early bone alterations in this category of patients is yet to found. The use of bone mineral density (BMD) is not as useful as in other causes of osteoporosis as excess GH leads to specific microarchitectural alteration of trabecular bone, which don’t translate ...

ea0065p288 | Neuroendocrinology | SFEBES2019

Modalities to overcome resistance to dopamine agonists in patients with macroprolactinomas

Trifanescu Raluca , Smarandoiu Alexandra , Baciu Ionela , Caragheorgheopol Andra , Dumitrascu Anda , Poiana Catalina

Background: Dopamine agonists (DA) are the first-line treatment for macroprolactinomas. However, up to 10% of patients fail to respond to medical therapy.Aim: To assess biochemical resistance rate to DA treatment in a large series of patients with macroprolactinoma and to analyze possibilities to overcome this resistance.Patients and methods: 195 patients with macroprolactinomas, treated with DA for at least 2 years, were retrospec...