Endocrine Abstracts

Endocrine tumour registry is a web-based system which is divided in several categories of endocrine tumours: pituitary adenomas, thyroid cancer, parathyroid tumours, adrenal and other types.The program is intended to give epidemiological data concerning the prevalence of each type, age and sex distribution, therapy and basic results of it. The centres involved are the medical universities and expertise centres in Romania, centres in which there are enoug...

Introduction: Although the metabolic impact of Cushing’s syndrome and hypercortisolemia are well known, the metabolic impact of ACTH is less established.Objective: To identify differences in the glucidic, lipid and bone metabolism in ACTH-dependent versus ACTH-independent Cushing’s syndrome.Methods: Retrospective, cross-sectional study of 99 patients with Cushing’s syndrome (54 with ACTH-dependent Cushing’s synd...

We report the case of a 36 years old female, with personal history of breast cancer, treated with neoadjuvant chemotherapy, breast sectorectomy and then chemotherapy and radiation therapy 2 years ago. She was continuously monitored by her oncologist, disease free for over a year, with recent CT scan that showed no particular lessions suggestive for secondary disease. Meanwhile, she got pregnant and delivered at term a healthy baby. She was admitted 3 months postpartum with int...

Differentiated thyroid cancers include papillary, follicular carcinomas and are usually associated with a good prognosis. Up to 10% of patients develop metastatic lessions and radioiodine resistance. Tirosine kinase inhibitors (TKI) represent a strong therapeutic option for patients with advanced metastatic disease and radioiodine resistance. Sorafenib is the only TKI approved for the treatment of locally advanced or metastatic differentiated radioiodine resistant thyroid carc...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder consisting in the development of primary hyperparathyroidism (PHPT), pancreatic neuroendocrine tumors, and pituitary adenomas. Occurrence of glucagonoma in MEN1 patients is rare (3%) and metastatic disease is present in 50% to 80% of patients at the time of diagnosis. The association of adrenal nodules/tumors and MEN1 is also rare.Case report: We present the case o...

Introduction: Neuroendocrine tumors (NET) represent a heterogeneous group of tumors with different locations, whose management is based on the pathology, immunohistochemical, genetic and molecular profile.Materials and method: We followed 8 patients with NET between 2014 and 2022 registered at the “C.I. Parhon” National Institute of Endocrinology, Bucharest, who benefited from peptide receptor radionuclide therapy (PRRT). Among them, 75% were m...

Introduction: Prolactin secreting pituitary adenoma represents the most common functioning pituitary neoplasm with a clinical picture that includes amenorrhea, galactorrhea and infertility. Tumor size may vary from microadenomas amendable to medical therapy with dopamine agonists to macroadenomas with difficult management. Complications are usually related to tumor size and most frequently include hypogonadism alone or associated with other pituitary deficiencies, visual field...

Introduction: A glucagonoma is a rare neuroendocrine tumor that originates almost exclusively in the pancreas and probably accounts for 1% of all neuroendocrine tumors. MEN11 is characterized by the development of primary hyperparathyroidism (PHPT), pancreatic neuroendocrine tumors and pituitary adenomas.Methods: We present the case of a 39-year-old female, with history of type 2 diabetes mellitus and hypokalemia2 who presented to t...

Introduction: The neuroendocrine tumor of the ampulla of Vater represent a very rare disease, corresponding up to 2% of the periampullary malignancies and less than 1% of gastrointestinal NET. Less than 130 patients have been reported until 2013. The biological and clinical behavior is very unpredictable especially if it’s associated with another tumor, like adenocarcinoma. We present a case of a fifty-one-years-old woman who complained of weight loss, jaundice, abdominal...

Neuroendocrine tumors (NETs) includes a broad family of tumors, the most frequent ones are in the gastrointestinal tract, lung, thymus, and pancreas. Gas-trointestinal and Pulmonary NETs may present with symptoms attributable to hormonal hypersecretion, which include intermit-tent flushing and diarrhea, or symptoms related to Cushing Syndrome. The variability of clinical manifestation may lead to late referral or misdiagnosis. In this retrospective study we analyzed 27 patient...