Endocrine Abstracts

We all encounter patients with osteoporosis in our daily practice - indeed the risk of osteoporotic fractures is increased in most endocrine disorders. The basic principles of diagnosing and treating osteoporosis and eliminating secondary causes remain simple and we should master them. However, providing truly excellent osteoporosis management is challenging and is much more than using the latest osteoporosis medication.There are challenges. Few clinicia...

We all encounter patients with osteoporosis in our daily practice - indeed the risk of osteoporotic fractures is increased in most endocrine disorders. The basic principles of diagnosing and treating osteoporosis and eliminating secondary causes remain simple and we should master them. However, providing truly excellent osteoporosis management is challenging and is much more than using the latest osteoporosis medication.There are challenges. Few clinicia...

Antiresorptive agents form an important part of the treatment strategy in almost every patient with osteoporosis. They are used both as the primary treatment option and as a means of maintaining gains in bone mass after bone anabolic therapy. Marketed drugs in this category comprise bisphosphonates, SERMs, calcitonin, and denosumab. By virtue of their effect on bone remodeling, potent antiresorptives have the potential to cause hypocalcaemia in susceptible patients (especially...

Thyroid hormones exert their effects by stimulation of thyroid hormone receptors that have different tissue distribution and metabolic targets. TRβ is predominant in liver and mainly responsible for effects on cholesterol and lipoprotein metabolism, whereas TRα is most important in fat, muscle and heart. Thyroid hormone analogs (thyromimetics, tiromes) have been developed that activate TRβ are selectively taken up and/or activated by the liver. Such compounds st...

Bisphenol A (BPA) is an environmental estrogen that is globally used in the production of plastics. Studies on BPA as an endocrine disruptor have focused on its estrogenic activity in vitro and in adult animal models. Recently, the National Toxicology Program at the US National Institutes of Health raised concerns for the neural and behavioral effects of BPA in fetuses, infants, and children at the currently allowed human exposures. However, the difficulty in studying u...

Objective: To investigate the relationship between expression of TLR2, TLR4, and TLR9 in PBMCs and type 2 diabetes and their significance in pathogenesis of diabetes.Methods: Expression of TLR2, TLR4, and TLR9 in PMBCs was measured by flow cytometry in 112 subjects with coronary heart disease (CHD, n=49), type 2 diabetes plus coronary heart disease (DM+CHD, n=34), type 2 diabetes (DM, n=4) and healthy controls (CONTROL, n</...

Aim: To minimize the duration of vitamin-D insufficiency, current treatment regimes are initiated with an oral bolus dose of cholecalciferol. We have previously developed an algorithm (# Dekristol caps/Vigantol ml =(80 nmol/l – initial [s-25-OH-d-vit])/7 nmol/l) for determining the dosage of this bolus, aimed at reaching a serum 25-OH vitamin-D of 80 nmol/l. Our main aim was to investigate the accuracy of this algorithm.Materials: A retrospective st...

In the central nervous system, the opioid and non-opioid transmitter system jointly compete with multiple pathophysiological processes. The in vitro neuronal model of rat (Wistar) caudate putamen and reverse transcription-poly-merase chain reaction were used to examine the effects of neurotensin and/or morphine on the expression of mu or delt-opioid receptor mRNA. In the present study neurotensin (10 nmol/l) promoted but morphine (0.001 mmol/l) reduced mu or delt-opioid...

Background: Handgrip strength (HGS) and skeletal muscle mass (SMM) are associated with all-cause and cardiovascular disease (CVD)-specific mortality risk in type 2 diabetes (T2DM) patients. However, the pattern of this association was unclear. We aimed to explore the pattern of associations between HGS and SMM with all-cause and CVD mortality risk in a diabetic population.Method: Data were obtained from the UK Biobank (application number 92014), a large ...

Objectives: The brain plays a major role in controlling the desire to eat. We performed a meta-analysis to assess the association of dopamine transporter (DAT)/dopamine receptor (DR) availabilities from neuroimaging studies with obesity.Methods: We performed a systematic search of MEDLINE and EMBASE for English-language publications. Data were extracted from the publications independently by two reviewers. Effect sizes were correlation coefficient betwee...