Searchable abstracts of presentations at key conferences in endocrinology

ea0050mc1.1 | Masterclass 1: Bone Masterclass | SFEBES2017

Osteoporosis management: the cutting edge

Abrahamsen Bo

We all encounter patients with osteoporosis in our daily practice - indeed the risk of osteoporotic fractures is increased in most endocrine disorders. The basic principles of diagnosing and treating osteoporosis and eliminating secondary causes remain simple and we should master them. However, providing truly excellent osteoporosis management is challenging and is much more than using the latest osteoporosis medication.There are challenges. Few clinicia...

ea0050mc1.1 | Masterclass 1: Bone Masterclass | SFEBES2017

Osteoporosis management: the cutting edge

Abrahamsen Bo

We all encounter patients with osteoporosis in our daily practice - indeed the risk of osteoporotic fractures is increased in most endocrine disorders. The basic principles of diagnosing and treating osteoporosis and eliminating secondary causes remain simple and we should master them. However, providing truly excellent osteoporosis management is challenging and is much more than using the latest osteoporosis medication.There are challenges. Few clinicia...

ea0028cmw2.3 | Controversies in aetiology and management of osteoporosis | SFEBES2012

Complications of antiresorptive agents

Abrahamsen Bo

Antiresorptive agents form an important part of the treatment strategy in almost every patient with osteoporosis. They are used both as the primary treatment option and as a means of maintaining gains in bone mass after bone anabolic therapy. Marketed drugs in this category comprise bisphosphonates, SERMs, calcitonin, and denosumab. By virtue of their effect on bone remodeling, potent antiresorptives have the potential to cause hypocalcaemia in susceptible patients (especially...

ea0025s6.4 | Novel application of thyroid hormone analogues: thyroid hormones, thinking outside the capsule | SFEBES2011

Liver: selective TR agonists for the treatment of dyslipidemia

Angelin Bo , Rudling Mats

Thyroid hormones exert their effects by stimulation of thyroid hormone receptors that have different tissue distribution and metabolic targets. TRβ is predominant in liver and mainly responsible for effects on cholesterol and lipoprotein metabolism, whereas TRα is most important in fat, muscle and heart. Thyroid hormone analogs (thyromimetics, tiromes) have been developed that activate TRβ are selectively taken up and/or activated by the liver. Such compounds st...

ea0020oc3.5 | Reproduction/Stress/Endocrine Disruptors | ECE2009

The xenoestrogen bisphenol A inhibits postembryonic vertebrate development by antagonizing gene regulation by thyroid hormone

Shi Yun-Bo

Bisphenol A (BPA) is an environmental estrogen that is globally used in the production of plastics. Studies on BPA as an endocrine disruptor have focused on its estrogenic activity in vitro and in adult animal models. Recently, the National Toxicology Program at the US National Institutes of Health raised concerns for the neural and behavioral effects of BPA in fetuses, infants, and children at the currently allowed human exposures. However, the difficulty in studying u...

ea0032p375 | Diabetes | ECE2013

Gene expression of TLR2, TLR4, and TLR9 in human PBMCs with diabetes

Liu Fengjing , Feng Bo , Bao Yuqian

Objective: To investigate the relationship between expression of TLR2, TLR4, and TLR9 in PBMCs and type 2 diabetes and their significance in pathogenesis of diabetes.Methods: Expression of TLR2, TLR4, and TLR9 in PMBCs was measured by flow cytometry in 112 subjects with coronary heart disease (CHD, n=49), type 2 diabetes plus coronary heart disease (DM+CHD, n=34), type 2 diabetes (DM, n=4) and healthy controls (CONTROL, n</...

ea0029p253 | Calcium &amp; Vitamin D metabolism | ICEECE2012

Treatment of vitamin D insufficiency with oral loading doses of cholecalciferol

Jansen R. Bo , Svendsen O. Lander

Aim: To minimize the duration of vitamin-D insufficiency, current treatment regimes are initiated with an oral bolus dose of cholecalciferol. We have previously developed an algorithm (# Dekristol caps/Vigantol ml =(80 nmol/l – initial [s-25-OH-d-vit])/7 nmol/l) for determining the dosage of this bolus, aimed at reaching a serum 25-OH vitamin-D of 80 nmol/l. Our main aim was to investigate the accuracy of this algorithm.Materials: A retrospective st...

ea0013p234 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Effects of neurotensin and/or morphine on gene expression of mu and delta opioid receptor

Bai Bo , Liu Haiqing , Liu Yuhong

In the central nervous system, the opioid and non-opioid transmitter system jointly compete with multiple pathophysiological processes. The in vitro neuronal model of rat (Wistar) caudate putamen and reverse transcription-poly-merase chain reaction were used to examine the effects of neurotensin and/or morphine on the expression of mu or delt-opioid receptor mRNA. In the present study neurotensin (10 nmol/l) promoted but morphine (0.001 mmol/l) reduced mu or delt-opioid...

ea0063p171 | Diabetes, Obesity and Metabolism 1 | ECE2019

Dopamine Receptor and Dopamine Transporter in Obesity: A Meta-analysis

Pak Kyoungjune , hyun Kim Bo , Kim Mijin , Kim Keunyoung

Objectives: The brain plays a major role in controlling the desire to eat. We performed a meta-analysis to assess the association of dopamine transporter (DAT)/dopamine receptor (DR) availabilities from neuroimaging studies with obesity.Methods: We performed a systematic search of MEDLINE and EMBASE for English-language publications. Data were extracted from the publications independently by two reviewers. Effect sizes were correlation coefficient betwee...

ea0063p172 | Diabetes, Obesity and Metabolism 1 | ECE2019

Cerebral glucose metabolism and Cerebral blood flow in Hypothyroidism and Hyperthyroidism: An activation likelihood estimation Meta-analysis

Pak Kyoungjune , Kim Bo hyun , Kim Mijin , Kim Keunyoung

Objective: Thyroid dysfunction is frequently associated with functional disturbances of the brain. We performed a meta-analysis of previous positron emission tomography and single-photon emission computed tomography studies using a coordinate-based technique of activation-likelihood estimation (ALE) to investigate the potential background of neuropsychiatric complications in patients with hypo- and hyperthyroidism.Methods: We performed a systematic searc...