Searchable abstracts of presentations at key conferences in endocrinology

ea0032p178 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Intestinal cholesterol-transport gene expression is associated with abnormalities in post-prandial endothelial function and carotid intima-media thickness independent of insulin resistance

Widdowson W Matthew , McGowan Anne , Phelan James , Boran Gerard , Reynolds John , Gibney James

Introduction: Intestinal cholesterol absorption is known to be important in post-prandial lipid levels, and implicated in the development of vascular disease. This study evaluated the effect of intestinal gene expression on markers of early vascular disease in a cohort of diabetic and non-diabetic subjects.Methods: Subjects were identified from routine upper GI lists and enrolled as per local ethics approval. Intestinal gene expression was measured on du...

ea0032p990 | Thyroid (non-cancer) | ECE2013

Postprandial studies uncover differing effects on HDL particles of overt and subclinical hypothyroidism

McGowan Anne , M Widdowson William , O'Regan Anna , S Young Ian , Boran Gerard , McEneny Jane , Gibney James

Overt hypothyroidism (OH) and more controversially subclinical hypothyroidism (SCH) are associated with abnormal lipid metabolism and endothelial dysfunction under fasting conditions. Little data exists regarding the metabolic and vascular effects of OH or SCH under postprandial conditions.We aimed to characterize postprandial metabolism with emphasis on intestinally derived lipoproteins, HDL-cholesterol (HDL-C) and endothelial function in patients with ...

ea0015p160 | Diabetes, metabolism and cardiovascular | SFEBES2008

Independent effects of insulin resistance and high molecular weight adiponectin on HDL cholesterol in polycystic ovarian syndrome

Phelan Niamh , O'Connor Annalouise , Tun Tommy Kway , Correia Neuman , Roche Helen , Boran Gerard , Gibney James

There is an increase in cardiovascular risk factors in polycystic ovarian syndrome (PCOS) compared with BMI matched controls. Almost all women with PCOS are insulin resistant and increased cardiovascular risk is commonly attributed to insulin resistance (IR). However, it is unclear if cardiovascular risk differs in women with PCOS compared to equally insulin resistant women. We performed a case–control study (n=56 pairs) of women with PCOS (NIH criteria) compared t...

ea0013p256 | Reproduction | SFEBES2007

Differential causes of hypertriglyceridaemia and low HDL-cholesterol in women with polycystic ovary syndrome

Tun Tommy Kyaw , Correia Neuman , Phelan Niamh , Roche Helen , Boran Gerard , Gibney James

Women with polycystic ovary syndrome (PCOS) have an increased prevalence of cardiovascular risk factors. Insulin resistance (IR) is believed to be an important factor in the pathogenesis of both PCOS and cardiovascular disease and thus provides a plausible link between these two conditions. An exaggerated post-prandial triglyceride (TG) response is thought to be one of the mechanisms through which IR is associated with atherosclerosis. The aim of this study was to compare fast...

ea0049ep487 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Lipoprotein particle size in women with type 1 diabetes mellitus and its relationship to carotid intima-media thickness

Gunness Anjuli , Ahmed Mohamed , Pazderska Agnieska , Phelan Niamh , Moore Kevin , Boran Gerard , Behan Lucy-Ann , Sherlock Mark , Gibney James

Although cardiovascular disease (CVD) is greatly increased in type 1 diabetes mellitus (T1DM), patients typically have apparently healthy lipid profiles. Simple measurement of plasma lipids however does not provide information regarding lipoprotein particle size which in the nondiabetic population is independently predictive of CVD. Plasma lipids and lipoprotein subclasses (using polyacrylamide gel-tube electrophoresis) were studied in reproductive age women with T1DM and comp...

ea0037ep196 | Reproduction, endocrine disruptors and signalling | ECE2015

Endocrinopathies associated with lithium therapy in an Irish tertiary referral centre

Dineen Rosemary , Bogdanet Delia , Thompson C J , Thompson D , Boran Gerard , Gibney James , Keane Veronica , Sherlock Mark

Lithium is used in psychiatric practice as maintenance therapy in bipolar disorder. It has a narrow therapeutic index with serious toxic potential. Lithium is associated with multiple endocrine and metabolic disturbances but data regarding the rates of these in individual patients is lacking. In a tertiary referral centre, all patients on lithium therapy from 2000 to 2014 were identified. The aim of this study was to assess the impact of lithium therapy on the development of e...

ea0031p74 | Clinical practice/governance and case reports | SFEBES2013

Spironolactone interference in the immunoassay of androstenedione in a patient with a cortisol-secreting adrenal adenoma

Broderick Deirdre , Crowley Rachel K , O'Shea Triona , Boran Gerard , Conlon Kevin , Maher Vincent , Gibney James , Sherlock Mark

A 48-year-old man was referred for investigation of uncontrolled hypertension on four agents (olmesartan, felodipine, hydrochlorothiazide and spironolactone) and a 3 cm right-sided adrenal adenoma (pre-contrast Hounsfield units 25). Endocrine investigation for the hypertension and adrenal mass included: androstenedione 19.9 nmol/l 2.8–10.5) (elevated on two occasions on a Siemens Coat-A-Count assay), DHEA 0.7 μmol/l (2.1–15.2), 1 mg overnight dexamethasone suppr...

ea0013p333 | Thyroid | SFEBES2007

Neuropsychological abnormalities in overt and sub-clinical hypothyroidism improve but do not normalise following 3 months replacement with L-thyroxine

Correia Neuman , Mullally Sinead , Tun Tommy Kyaw , Phelan Niamh , Fitzgibbon Maria , O’Mara Shane , Boran Gerard , Gibney James

The neuropsychological mechanism underlying cognitive impairment in hypothyroidism is poorly understood. It is not known whether cognitive impairment resolves following L-Thyroxine (LT4) replacement. It is also unknown whether similar neuropsychological abnormalities occur in patients with sub-clinical hypothyroidism (SCH). To address these questions, we performed neuropsychological tests in 17 patients with hypothyroidism (age 45±3 years; mean±S.E.M.)...

ea0049ep1150 | Female Reproduction | ECE2017

Biochemical and clinical characteristics of polysystic ovarian syndrome (PCOS) in women with and without type 1 diabetes (TID)

Gunness Anjuli , Pazderska Agnieska , Ahmed Mohamed , Phelan Niamh , Boran Gerard , Taylor AE , O'Reilly MW , Arlt Wiebke , Moore Kevin , Behan Lucy-Ann , Sherlock Mark , Gibney James

Abstract: PCOS prevalence is reported to be increased in reproductive-age women with type-1 diabetes (T1DM) but measurement of androgens, crucial for diagnosis, has been with inaccurate immunoassays. No studies have been reported using liquid-chromatography-mass-spectrometry (LCMS). Reproductive-age T1DM women attending a single centre were evaluated for PCOS (NIH criteria). Women with T1DM and PCOS (T1/PCOS) were compared to T1DM women without hyperandrogenism (T1/no HA), and...

ea0049ep1153 | Female Reproduction | ECE2017

Androgen profiling by liquid chromatography-mass spectrometry (LC-MS) in reproductive-age women with and without diabetes

Gunness Anjuli , Pazderska Agnieska , Ahmed Mohamed , Phelan Niamh , Boran Gerard , Taylor AE , O'Reilly MW , Arlt Wiebke , Moore Kevin , Behan Lucy-Ann , Sherlock Mark , Gibney James

Abstract: The prevalence of hyperandrogenism has been reported to be increased in reproductive-age women with type-1 diabetes (T1DM). This observation however is based on findings using inaccurate immunoassays. No studies have been reported in diabetes using liquid-chromatography-mass-spectrometry (LCMS). We compared LCMS-measured androgens in T1DM-women with age-/ BMI-matched normal women, and compared findings with those in women with type-2 diabetes (T2DM) also compared to ...