Endocrine Abstracts

Introduction: Adipocyte fatty acid binding protein (A-FABP) is mainly expressed in adipocytes, and circulating A-FABP has been associated with markers of obesity. Women with PCOS are at increased risk of developing abdominal obesity what could be related to serum concentration of A-FABP.Aim: The aim of the present study was to investigate the relationships between serum concentration of A-FABP and parameters of obesity e.g. waist to hip ratio (WHR) and t...

Differentiated thyroid cancer (DTC) is the most common malignant neoplasm arising from the thyroid parenchymal cells. DTC incidence is steadily increasing worldwide and there are approximately 1700 new cases/per year in Poland. The biopsy with subsequent thyroid resection plays a central role in the diagnosis and treatment of this malignancy. After surgery, radioactive iodine (RAI) treatment is recommended to eradicate potential residual disease and improve prognosis. Due to t...

Background: Cardiovascular (CVS) risk factors could be present in patients with mild adrenal autonomous cortisol secretion (MACS), which could account for up to 50% of patients with adrenal adenomas. However, the most frequent CVS risk factors in MACS have not been established.Objective: The aim of the present study was to analyse the difference in CVS risk factors in patients with MACS in comparison to those with non-functioning adrenal tumour (NFAT).</...

Differentiated thyroid cancer (DTC) is the most common malignant neoplasm arising from the thyroid parenchymal cells. DTC risk stratification is a multi-stage process based on investigated histopathological features and ultrasound test outcomes combined with biochemical test results. Thus, searching for novel diagnostic indicators useful in cancer risk stratification are still needed. Recent studies revealed that oxidative and epigenetic alterations in DTC represent the signat...

Hashimoto disease, a chronic autoimmune lymphocytic thyroiditis, is the most common cause of hypothyroidism with a prevalence of 10–12% in the general population. Literature data suggests that persistently high levels of oxidative are considered as relevant risk factor in the occurrence and development of autoimmune diseases, including Hashimoto. The DNA and RNA are particularly valuable to the oxidative damage, and guanine is the most prone base to oxidation. Thus, the D...

The most effective conventional treatment for differentiated thyroid cancer (DTC) still remains total thyroidectomy with subsequent adjuvant therapy with radioiodine ablation (RAI). In case of unsuccessful RAI treatment, an alternative method is the tyrosine kinase inhibitor therapy. However, its usage is related to many side effects and is not well tolerated by patients. Despite the great progress in the clinical management of patients with DTC, the lack of alternative therap...

Recently, 59 percent of European adults was diagnosed with obesity or overweight according to the 2022 Regional Obesity Report presented by the World Health Organization (WHO). Thus, insight into factors implicated in overweight and obesity may have important therapeutic implications. Interestingly, increased cortisol secretion and psychosocial stress have been demonstrated to be related with body weight-dependent insulin resistance and beta cells failure. Thus, the study was ...

Objective: Women with Hashimoto thyroiditis (HT) could have fertility problems. Serum anti-Müllerian hormone (AMH), which reflects functional ovarian reserve, is decreased in women with HT. The aim of the present study was to investigate the relation between serum levels of AMH and insulin resistance in women with HT compared to control group. Patients and methods: We examined 193 women: 37 subjects with HT, without previous history of treatment wit...

ObjectiveIt has been shown that treatment with radioactive iodine (RAI) of women with differentiated thyroid cancer (DTC) is connected with decreased serum concentration of anti-Müllerian hormone (AMH). To date, others markers connected with ovarian reserve have not been investigated yet. Therefore, the aim of the present study was to evaluate the effect of RAI on serum concentration of inhibin B, follicle stimulating hormone (FSH), AMH and antral f...