Searchable abstracts of presentations at key conferences in endocrinology

ea0022p372 | Endocrine Disruptors | ECE2010

Evaluation of paraxonase activity, malondialdehyde and thiol levels in patients with hypogonadism before and after treatment

Bayram Fahri , Baskol Gulden , Demirkoparan Umit , Gundogan Kursad , Cakir Ilkay

Objectives: Hypogonadism is associated with a higher risk of atherosclerosis and cardiovascular disease, but the mechanisms underlying this association are not yet fully understood. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. We aimed to determine serum PON1 activities, an established lipid antioxidant, MDA levels which are end products of lipid peroxidation induced by ROS and thiol groups as an antioxidant fo...

ea0022p374 | Endocrine Disruptors | ECE2010

Paraoxonase is reduced in patients with GH deficiency: a risk factor for atherosclerosis?

Bayram Fahri , Baskol Gulden , Tanriverdi Fatih , Kocer Derya , Cakir Ilkay

Objective: GH deficiency is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to determine i) serum PON1 activities, an established lipid antioxidant, ii) MDA levels which are end products of lipid peroxidation induced by ROS and iii) thiol groups as an antioxidant for evaluating oxidative stress in patients with GHD before and aft...

ea0063p296 | Pituitary and Neuroendocrinology 1 | ECE2019

A Case of Granulomatous Hypophysitis Mimicking Pituitary Macroadenoma

Dogansen Sema Ciftci , Gunaldi Omur , Tanrıverdi Osman , Cakir Ilkay , Mert Meral

Idiopathic granulomatoushypophysitis is a rare inflammatory disease which is characterized by inflammation and cellular infiltration of the pituitary gland. The infiltration may cause pituitary insufficiency, compression symptoms due to mass effect and diabetes insipidus. We report the case of a 33-year-old female patient who presenting with weakness, fatigue, amenorrhea and worsening of headaches about 3 months. The patient did not have blurring vision and polyuria-polydipsia...

ea0037ep580 | Obesity and cardiovascular endocrinology | ECE2015

Preoperative endocrinological evaluation of patients apply for bariatric surgery

Cakir Ilkay , Simsek Yasin , Kutanis Riza , Menekse Serkan , Ustun Emine Isil , Sit Dede

Introduction: Since bariatric surgery is considered to be a more effective treatment modality for morbid obesity, a growing number of patients have been referred to endocrinology clinics in order to exclude an underlying cause. Routine preoperative testing to screen CushingÂ’s syndrome (CS) or hypothyroidism is still debatable. The aim of this study is to evaluate the accuracy of routine testing in preoperative endocrinological evaluation.Methods/des...

ea0037ep1063 | Thyroid (non-cancer) | ECE2015

The effect of vitamin D on thyroid autoimmunity

Simsek Yasin , Cakir Ilkay , Kucukler Ferit Kerim , Diri Halit , Baglicakoglu Murat , Guler Serdar

Introduction: Although, vitamin D (vit D) mainly regulates calcium and phosphate metabolisms, its deficiency may also contribute to the development of some carcinomas, autoimmune, and cardiac diseases. Vit D deficiency has been defined to correlate with increased autoimmune disease such as type 1 diabetes mellitus, rheumatoid arthritis, autoimmune thyroid diseases (AITD). Previous studies suggested that patients with AITD had lower vit D levels when compared with healthy contr...

ea0022p373 | Endocrine Disruptors | ECE2010

Micronucleus evaluation in mitogen-stimulated lymphocytes of patients with acromegaly

Cakir Ilkay , Hamurcu Zuhal , Donmez-Altuntas Hamiyet , Bitgen Nazmiye , Karaca Zuleyha , Elbuken Gulsah , Bayram Fahri

Aim: Acromegaly is an endocrine disorder characterized by sustained elevation of circulating GH and insulin-like growth factor (IGF1). IGF1 is a potent mitogen and has a role in the transformation of normal cells to malignant cells. Micronucleus (MN) frequency is a biomarker of chromosomal damage, genome instability and cancer risk. Our study aimed to evaluate spontaneous MN frequency by using the cytokinesis block MN assay to determine genetic damage in lymphoytes of patients...

ea0022p567 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Effects of GH replacement therapy on hematopoiesis and immune function: a placebo controlled study

Cakir Ilkay , Tanriverdi Fatih , Karaca Zuleyha , Kaynar Leylagul , Elbuken Gulsah , Eser Bulent , Unluhizarci Kursad , Kelestimur Fahrettin

Objectives: It has been recently recognized that GH may have a role in hematopoiesis and immune system. However, there are conflicting data regarding the effects of GH deficiency (GHD) and/or GH replacement therapy in GH deficient patients on hematopoiesis and immune system. The aim of the present study was to investigate the peripheral blood cell counts, T- and B-lymphocyte subsets and immunoglobulin levels before and after GH replacement therapy in patients with adult onset ...

ea0022p759 | Thyroid | ECE2010

Expressions of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGF1), insulin like growth factor 1 (IGF1) and IGF1 receptor in differentiated thyroid carcinoma

Karaca Zuleyha , Tanriverdi Fatih , Ozturk Figen , Elbuken Gulsah , Cakir Ilkay , Unluhizarci Kursad , Bayram Fahri , Kelestimur Fahrettin

Objective: Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 1 (VEGFR1) are known to be related to thyroid tumorigenesis, but data are limited about their relationship with insulin like growth factor 1 (IGF1) and IGF1 receptor. The aim of this study was to clarify the role of VEGF, VEGFR-1, IGF1 and IGF1 receptor in thyroid tumorigenesis.Methods: We examined 40 patients with differentiated thyroid carcinoma (DTC) a...

ea0022p204 | Clinical case reports and clinical practice | ECE2010

Ganglioneuroblastoma: a rare cause of adrenal mass in adults

Elbuken Gulsah , Karaca Zuleyha , Cakir Ilkay , Tanriverdi Fatih , Gulec Mustafa , Akcan Alper , Akgun Hulya , Unluhizarci Kursad , Kelestimur Fahrettin

Introduction: Neurogenic tumors in abdomen arise from ganglion cell origin and usually seen in the distribution of the sympathetic ganglia along paraspinal areas or adrenal medulla or the organ of Zuckerkandl.Ganglioneuroblastomas are the tumors of sympathetic cell origin which have the features of both malignant and benign neuroblastoma. The presence of immature tissue indicates potentially a malignant behavior. Ganglioneuroblastomas are most often seen...

ea0073aep505 | Pituitary and Neuroendocrinology | ECE2021

Increased anxiety and perceived stress in active acromegaly during the COVID-19 pandemic

Turgut Seda , Piskinpasa Hamide , Acarer Didem , Karaarslan Ozlem , Bozkur Evin , Pamuk Naim , Cakir Ilkay , Mert Meral , Dogansen Sema Ciftci

AimTo examine and compare the anxiety level and stress perception of acromegaly patients with controlled and active disease in the COVID-19 pandemic.Material and Method49 (23 females/26 males) patients admitted to the outpatient clinic during the first month after the pandemic period were recruited in this cross-sectional study. State-Trait Anxiety Inventory (S-Anxiety for state scale, T-Anxiety for trait sca...