Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1481 | Thyroid (non-cancer) | ECE2017

Lymph node categorization as a prognostic factor in a historical series of medullary thyroid cancer cases within a regional hospital

Moreno Nerea Aguirre , Gonzalez Elena Fernandez , Mena Sandra Campos , Azpiroz Monica Marazuela , Vargas Marcos Lahera

Introduction: Medullary thyroid cancer (MTC) TNM classification categorizes lymph nodes (LN) according to their location, but does not consider number and size of LN.Objective: To analyze the relationship between number and size of LN in MCT persistent disease (PD).Material and methods: Retrospective study of patients with MTC followed up in a regional hospital from 1985 to 2015. The main variables (expressed as qualitative in freq...

ea0037ep273 | Calcium and Vitamin D metabolism | ECE2015

Bone mineral density evolution after parathyroidectomy in patients with primary hyperparathyroidism

Vicuna Alicia , Ramos-Levi Ana , Sampedro-Nunez Miguel , Campos Sandra , Zelada Magaly , Marazuela Monica

Introduction: Primary hyperparathyroidism results in increased bone resorption. The presence of osteoporosis is at present an established surgery criteria.Objective: The aim of this study was to evaluate the changes in bone mineral density (BMD) after surgery in patients with primary hyperparathyroidism.Material and methods: Retrospective study of 58 patients with primary hyperparathyroidism treated by parathyroidectomy from 2004 t...

ea0049oc10.2 | Bone & Calcium Homeostasis | ECE2017

Evaluation of bone quality, measured by trabecular bone score (TBS) in patients with primary hyperparathyroidism (PHH) with and without surgery

Huguet Isabel , Sampedro-Nunez Miguel , Munoz De Nova Jose Luis , Ramos-Levi Ana , Campos Sandra , Escolano Eugenio , Marazuela Monica

Evaluation of bone quality represents a challenge since the analysis by bone mineral density (BMD), provides useful but incomplete information. New tools are arising, and amog them, TBS is emerging as a new surrogate marker of bone texture and microarchitecture which may be useful to potentially evaluate the risk of bone fracture and can be obtained from already existing BMD scans. Retrospective study of 23 patients with PHH. Clinical, analytical and BMD data were collected fo...

ea0035p719 | Neuroendocrinology | ECE2014

Effects of pharmacological blockade of glucocorticoids on energy homeostasis control by liver and pancreas in rats without pineal gland

Rodrigues Sandra Campos , Pantaleao Lucas Carminatti , de Araujo Veras Katherine M. , Amaral Fernanda Gaspar , Anhe Gabriel Forato , Bordin Silvana

In liver, melatonin (Mel) and glucocorticoids (GC) influence the systemic energy homeostasis. Animals without pineal gland present impairment in glycemic control, as in type-2 diabetes. In turn, Mel reduces the GC levels, particularly in nocturnal animals. We aimed to evaluate the influence of Mel, as well as GC receptor blockade by RU486 treatment on hepatic and pancreatic energy metabolism. Male Wistar rats were subjected to surgical removal of pineal and, 25 days after the ...

ea0014p338 | (1) | ECE2007

Prevalence of thyroid antibodies in gestational diabetes mellitus

Ruas Luísa , Paiva Sandra , Campos Maria , Marta Elvira , Lobo António , Cravo Annette , Carvalheiro Manuela

Background: Pregnancy alters the natural history of autoimmune thyroid disorders. The incidence rate of positive thyroid antibodies (T-abs +) in asymptomatic women during pregnancy has been reported to be between 6 and 19.6%.Aim: To determine the prevalence of thyroid antibodies (T-abs) in Gestational Diabetes Mellitus (GDM).Subjects & Method: In 408 women, at the time of diagnose of GDM, TSH, free thyroxine, free tri-iodothyro...

ea0049ep180 | Endocrine tumours and neoplasia | ECE2017

Survival analysis of patients with gastroenteropancreatic neuroendocrine tumors

Sampedro-Nunez Miguel , Maillo-Nieto Angeles , Ramos-Levi Ana Maria , Huguet Isabel , Campos Sandra , Fernandez Elena , Aguirre Nerea , Munoz de Nova Jose Luis , Martin Elena , Marazuela Monica

Introduction: One of the main difficulties in the study of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is their wide heterogeneity and variable outcome. Several potential influencing factors on patient survival have been recently identified. These factors could help predict patientsÂ’ prognosis.Objectives: Analysis of long-term survival of our GEP-NETs cohort according to the presence of metastatic disease, tumor grade, age, sex, tumor fu...

ea0037gp.28.09 | Endocrine tumours and neoplasia – NETS | ECE2015

Association of angiopoietin/TIE2 plasma level and VEGF system with progression in gastroenteropancreatic neuroendocrine tumors

Sampedro-Nunez Miguel , Ramos-Levi Ana , Vicuna Alicia , Campos Sandra , Serrano Ana , Rodriguez-Munoz Ana , Martinez-Hernandez Rebeca , Martin-Perez Elena , Adrados Magdalena , Marazuela Monica

Introduction: Angiopoietins (ANG) -1 and 2, their receptor TIE2, and the vascular endothelial growth factor (VEGF) are involved in the process of angiogenesis. However, their role in the pathogenesis and development of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is not completely understood. In a previous study of 42 patients with GEP-NET, we observed an elevation of these serum markers, especially in those with metastatic disease. The objective of this study was ...