Searchable abstracts of presentations at key conferences in endocrinology

ea0099p503 | Endocrine-Related Cancer | ECE2024

Presurgical lactate dehydrogenase (LDH) levels: A risk factor for disease progression in operated adrenocortical carcinomas

Carreira Ana , Guiomar Joana , Festas Diana , Catarino Diana , Rodrigues Dircea , Moreno Carolina , Melo Miguel , Paiva Isabel

Introduction: Adrenocortical carcinoma (ACC) is a rare malignancy with high recurrence and poor prognosis. Lactate dehydrogenase (LDH) is an enzyme of the glycolytic pathway that is associated with tumour progression in several cancers. To date, evidence on the prognostic value of LDH in ACC is limited.Aims: To assess the impact of LDH in disease-free survival (DFS) in operated ACC.Materials and methods: Retrospective cohort study ...

ea0063p947 | Diabetes, Obesity and Metabolism 3 | ECE2019

Autoimmune diabetes mellitus versus idiopathic: differences at diagnosis

Silva Diana , Catarino Diana , Pereira Claudia , Ruas Luisa , Ribeiro Cristina , Cunha Nelson , Fadiga Lucia , Guiomar Joana , Cardoso Luis , Paiva Isabel , Carrilho Francisco

Introduction: The American Diabetes Association proposed two categories for the classification of type 1 diabetes mellitus (DM): autoimmune (AI) and idiopathic (ID). The absence of autoimmune markers or association with HLA haplotypes defines the second category. Only a small minority of patients with type 1 diabetes fall into this category.Objective: To evaluate the clinical characteristics of both categories and to analyze the differe...

ea0063p1195 | Thyroid 3 | ECE2019

Amiodarone-induced thyrotoxicosis: when combined treatment is an option

Silva Diana , Ruas Luisa , Cunha Nelson , Catarino Diana , Fadiga Lucia , Guiomar Joana , Carrilho Francisco

Introduction: Amiodarone is an effective drug in the management of supraventricular arrhythmias. Due to its composition rich in iodine and pharmacological properties can cause thyroid dysfunction in 15–20% of the treated patients. Clinically it can present in the form of amiodarone-induced hypothyroidism or amiodarone-induced thyrotoxicosis. This latter situation may result from an excess of iodine supply, glandular destruction or both pathogenic mechanisms.<p class="...

ea0056p998 | Clinical case reports - Thyroid/Others | ECE2018

Type 1 diabetes mellitus and sorafenib: coincidence or consequence?

Ribeiro Cristina , Catarino Diana , Oliveira Diana , Saraiva Joana , Melo Miguel , Paiva Sandra , Carrilho Francisco

Introduction: Differentiated thyroid carcinoma is usually associated with a good prognosis. However, some of these tumors (5%) are radioiodine refractory and have different progression, associated with poor prognosis. In these situations, some tyrosine kinase inhibitors (TKI) can be used. We present a clinical case showing the difficulties in the follow-up and treatment of these patients.Clinical case: A 60 years old woman, with a “multicentric papi...

ea0063p242 | Pituitary and Neuroendocrinology 1 | ECE2019

Pituitary tumors diagnosed in octogenarians – clinical implications

Cunha Nelson , Gomes Leonor , Paiva Isabel , Fadiga Lucia , Catarino Diana , Silva Diana , Guiomar Joana , Vieira Ines , Lavrador Mariana , Bastos Margarida

Introduction: The aging population brought new challenges in several diseases. Pituitary tumors are usually not related with elderly, although the rise in life expectancy has allowed its diagnosis in unusual age groups.Aim: To describe the pituitary tumors diagnosed in patients with age ≥ 80 yearsMethods: Retrospective observational study which included 23 patients with pituitary tumors with age ≥ 80 years observed in c...

ea0063p1128 | Reproductive Endocrinology 2 | ECE2019

Turner’s syndrome: adult life’s implications

Guiomar Joana Reis , Moreno Carolina , Cunha Nelson , Marques Bernardo , Catarino Diana , Fadiga Lucia , Silva Diana Festas , Bastos Margarida

Introduction: Turner syndrome (TS) is one of the most common chromosomal abnormalities, characterized by systemic involvement and susceptibility to some disorders that begin or progress in adult life. These lead to an increase in morbidity and mortality and a decrease in quality of life. The aim of this study was to analyse the profile of women with TS, who are currently followed in endocrinology, regarding: karyotype, age, final height and weight, puberty and fertility, and m...

ea0049ep444 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Testosterone levels in men with diabetes mellitus. What relation?

Cunha Nelson , Gomes Leonor , Martins Diana , Oliveira Diana , Lages Adriana , Ventura Mara , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Background: Low serum testosterone (LST) is associated with some chronic diseases, changes in body composition and resistance to insulin. Diabetes is one condition that has high prevalence of LST.Objetive: To determine the prevalence of LST in men with diabetes and its relationship with age, anthropometric and biochemical data.Material and methods: A cross-sectional study of 65 men with type 1 and type 2 diabetes was conducted, wit...

ea0049ep445 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Vitamin D and testosterone in diabetes mellitus: cross-sectional study results

Cunha Nelson , Gomes Leonor , Martins Diana , Oliveira Diana , Lages Adriana , Ventura Mara , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Background: In the recent years, Vitamin D role has grown in cardiovascular and inflammatory diseases, and some relations were made with low serum testosterone (LST) levels. It is equally known that in patients with diabetes, the prevalence of LST is higher.Objetive: To determine the prevalence of low levels of vitamin D and its relation with LST in men with diabetes.Material and methods: A cross-sectional study of 65 men with type...

ea0049ep1195 | Clinical case reports - Thyroid/Others | ECE2017

Amiodarone and refractory thyrotoxicosis in a patient with complex arrhythmia

Cunha Nelson , Gomes Leonor , Martins Diana , Oliveira Diana , Lages Adriana , Ventura Mara , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Background: Amiodarone is a potent antiarrhythmic drug used to treat tachyarrhythmias. However, is linked to a number of adverse effects, including thyroid dysfunction. It is the main cause of drug-induced thyrotoxicosis. Here we report a clinical case of amiodarone-induced thyrotoxicosis (AIT) in a patient with complex ventricular dysrhythmia.Case report: A 23 years-old women with dilated cardiomyopathy, severe depression of ejection fraction of left ve...

ea0070aep896 | Thyroid | ECE2020

PTEN-hamartoma tumour syndrome and thyroid nodular disease: 3 case reports

Fadiga Lúcia , Catarino Diana , Saraiva Joana , Dinis Isabel , Cardoso Rita , Serra Caetano Joana , Paiva Isabel , Mirante Alice

Introduction: Germline mutations in tumour suppressor gene PTEN cause heterogeneous phenotypes, that comprise the spectrum of PTEN-hamartoma tumour syndrome (PHTS). Manifestations include macrocephaly, developmental delay, cutaneous lesions, intestinal polyposis and increased risk of neoplasms. Thyroid nodules are identified in about 75% of patients and follicular cell-derived cancer affects 35% of cases, some of which diagnosed as early as 7 years old.C...