Endocrine Abstracts

Introduction and Objectives: Poor metabolic control in Type 1 Diabetes Mellitus (DM 1) is associated with micro and macrovascular complications. The implementation of interstitial glucose monitoring systems has contributed to improving glycemic control in recent years. Our objective was to know the metabolic control in people with type 1 DM and the Flash system and to establish if there is an association between its use and glycemic control variables.Mat...

Introduction: DM 1 is proposed as a condition of accelerated muscle aging and mitochondrial dysfunction as a common link regulating muscle deterioration in aging and DM 1. Loss of muscle mass is associated with insulin resistance, metabolic syndrome and cardiovascular complications.Objectives: To analyze body composition and metabolic variables related to insulin resistance in overweight/obese patients with DM1.Material and MethodsObservational, cross-se...

Precedents: Thirty-nine year old Woman. Classic phenylketonuria diagnosed for neonatal screening in Germany. Good adherence to the diet from the infancy, with good metabolic control. Not response to test with BH4.Pregnancy in 2007 with good controls of phenylalanine (Phe). Son with congenital cardiopathy.Evolution: In 2013 she planed new pregnancy, departing from very good controls (<4 mg/dl) and ingestion of 22–24 Phe&#14...

Introduction: Hypophosphatasia (HPP) is an inherited disease, characterized by a non-tissue-specific alkaline phosphatase deficiency that leads to abnormal mineralization of bone tissue, which promotes fragility fractures. A defective muscle status could have important clinical repercussions on fracture risk. The aim of this work was to evaluate the relationship between bone and muscle compartment.Material and Methods: Observational cross-sectional study...

Introduction: Hypophosphatasia (HPP) is characterised by a deficiency of non-tissue-specific alkaline phosphatase. This results in abnormal mineralisation of bone tissue which predisposes to fragility fractures. Moreover, an affected muscle compartment could favour the risk of fracture. The aim was to evaluate the relationship between the bone and muscle compartment.Material and Methods: Cross-sectional study in adults with PPH. Demographic (age, sex), a...

Introduction: Hypophosphatasia (HPP) presents with defective bone mineralisation secondary to a deficit of non-tissue-specific alkaline phosphatase, increasing the risk of bone fracture. Sarcopenia may increase this risk. Therefore, rapid diagnosis with accessible and cost-effective tools such as ultrasound could be useful in clinical practice. The aim was to assess the correlation of ultrasound with another validated muscle mass assessment technique.Mat...